Effect of Gluten Containing Diet on Pristane Induced Lupus Prone Mice

Mansoor, Muhammad; Abbas, Zaigham; Husssain, Nageen

doi:10.17582/journal.pjz/2017.49.4.1285.1293

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Other substances, such as tofacitinib and melatonin, also alleviated the progression of pristane‐induced lupus [31–33]. However, the administration of gluten in the diet of the experimental mice had the opposite effect [34]. Interestingly, retinoic acid had a dual effect in this lupus model depending on the phase of disease development [35].…”

Section: Discussionmentioning

confidence: 99%

Methyl‐supplemented nutrition delays the development of autoimmune disease in pristane‐induced murine lupus

Bradyanova,

Manoylov,

Boneva

et al. 2024

Immunology

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The aetiology and progression of systemic lupus erythematosus (SLE) resulted from a complex sequence of events generated both from genetic and epigenetic processes. In the current research, the effect of methyl‐supplemented nutrition on the development of SLE was studied in the pristane‐induced mouse model of the disease. The results clearly demonstrated decreased anti‐dsDNA antibody and proteinuria levels, modulation of cytokines and protected renal structures in the group of treated mice. An additional increase in the DNA methylation of mouse B lymphocytes was also observed. The beneficial effect of the diet is due to the methyl‐containing micronutrients with possible anti‐inflammatory and immunomodulating effects on cell proliferation and gene expression. Since these components are responsible for maintaining the physiological methylation level of DNA, the results point to the central role of methylation processes in environmentally triggered lupus. As nutrition represents one of the major epigenetic factors, these micronutrients may be considered novel agents with significant therapeutic outcomes.

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Section: Discussionmentioning

confidence: 99%

Methyl‐supplemented nutrition delays the development of autoimmune disease in pristane‐induced murine lupus

Bradyanova,

Manoylov,

Boneva

et al. 2024

Immunology

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“…When sarcoidosis patients were compared to healthy controls, the researchers discovered substantial variations in the number of certain intestinal bacterial species. The authors hypothesized that the immunological dysregulation found in sarcoidosis may be caused by these alterations in the gut flora [ 86 ]. Overall, while there is some evidence that suggests that alterations in the microbial flora may be related to sarcoidosis, further studies are required to completely understand this association.…”

Section: Introductionmentioning

confidence: 99%

Dietary Implications of the Bidirectional Relationship between the Gut Microflora and Inflammatory Diseases with Special Emphasis on Irritable Bowel Disease: Current and Future Perspective

et al. 2023

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The immune system is vital for safeguarding the human body against infections and inflammatory diseases. The role of diet and meal patterns in modulating immune function is complex, and highlighting this topic is crucial for identifying potential ways to improve immune health. In Europe, the Mediterranean diet and Western diet are the most common dietary patterns, and gaining an understanding of how they affect immune function is essential for public health. There are numerous inflammatory diseases that are observed in younger and older people. Some of the common diseases include polymyalgia rheumatica (PMR), spinal muscular atrophy (SMA), vasculitis, sarcopenia, cirrhosis, cancer, and fibromyalgia, but the main focus in this review article is on irritable bowel disease (IBD). In general, dietary choices can have an immense impact on the microbial flora of the gut in people with inflammatory diseases. The intake of Mediterranean-style foods promotes the growth of healthy bacteria that enhances the function of the immune system. On the other hand, it is mostly seen that the intake of Western-style foods leads to the growth of harmful gut bacteria that contributes to inflammation and disease development by weakening the immune system. Additionally, inflammation in the gut can impact brain function, leading to mood disorders, such as anxiety and depression. Rare inflammatory diseases, such as psoriasis and sarcoidosis, are of main interest in this article. All the above-mentioned common and rare inflammatory diseases have a certain relationship with the microbiota of the gut. The gut microbiome plays a significant role in IBD; fiber and prebiotic interventions may represent promising adjunct therapies for pediatric IBD by targeting the gut microbiome. By advancing a good overall arrangement of microorganisms in the stomach through dietary mediations, working on the side effects and alleviating of diseases might be conceivable. The gut microbiota can be affected differently by various dietary fatty acid types. There is also an involvement of genetics in the progression of IBD, such as transcriptional factors, and one gene of interest is the LCT gene, which encodes for lactase, an enzyme responsible for digesting lactose in the gut.

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Effect of Gluten Containing Diet on Pristane Induced Lupus Prone Mice

Cited by 2 publications

References 12 publications

Methyl‐supplemented nutrition delays the development of autoimmune disease in pristane‐induced murine lupus

Methyl‐supplemented nutrition delays the development of autoimmune disease in pristane‐induced murine lupus

Dietary Implications of the Bidirectional Relationship between the Gut Microflora and Inflammatory Diseases with Special Emphasis on Irritable Bowel Disease: Current and Future Perspective

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