Effect of Gluten-Free Diet on Dermatological, Intestinal, and Hæmatological Manifestations of Dermatitis Herpetiformis

Fry, Lionel; McMinn, R. M. H.; Cowan, JeanD.; Hoffbrand, A. V.

doi:10.1016/s0140-6736(68)92830-4

Cited by 140 publications

(48 citation statements)

References 16 publications

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“…It has been demonstrated that two-thirds of the patients with DH have a jejunal mucosa damage similar to that ob served in CD [10]. Intestinal abnormalities improve in DH, as well as in CD patients, after gluten withdrawal and relapse after glu ten challenge [9,11], Thus, the sensitivity of the AGA test in adult patients (ACD, DH) varies according to the nature of the underly ing gluten-sensitive enteropathy. The speci ficity of AGA is, on the whole, fairly high since AGA have been detected in a small pro portion (8-13%) of control patients (with in testinal and non-intestinal disorders) [2,6,7].…”

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confidence: 97%

Antibodies to Gliadin in Adult Coeliac Disease and Dermatitis herpetiformis

et al. 1984

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Antibodies to gliadin, searched for by indirect immunofluorescence and a micro-ELISA, were detected in 16 (64%) of 25 sera from patients with adult coeliac disease and in 13 (45%) of 29 with dermatitis herpetiformis. Although the sensitivity of the two tests was relatively low in the whole groups, it increased when only cases with severe jejunum abnormalities were considered (93% for coeliac disease and 81% for dermatitis herpetiformis). A significant correlation was found between antigliadin antibodies and the severity of jejunum damage in both diseases. Moreover, most coeliac and dermatitis herpertiformis patients with antigliadin antibodies were on normal diet. The specificity of the tests was 100% for the immunofluorescence and fairly good for the micro-ELISA, as only 5(11 %) of the 46 disease control patients (Crohn’s disease, ulcerative colitis) were positive for antigliadin antibodies. R1 -reticulin antibody test was equally specific but less sensitive in both groups. We conclude that antigliadin antibodies are useful in the diagnosis of patients with active adult coeliac disease and dermatitis herpetiformis with gluten-sensitive enteropathy. Moreover, the two tests make it possible to monitor the compliance to gluten-free diet in both diseases.

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confidence: 97%

Antibodies to Gliadin in Adult Coeliac Disease and Dermatitis herpetiformis

et al. 1984

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“…As was stated by Fry el al. [7], 3 patients no longer manifested any symptoms and did not need any more dapsone®, while in 3 other patients, lower doses of dapsone® proved to be sufficient. Gluten exposure provoked a relapse of the skin symptoms.…”

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confidence: 92%

“…Morphological and functional changes of the small intestine, similar to those of idiopathic steatorrhoea, were mainly described with der m atitis herpetiformis (DH) [1,3,4,5,6,7,10,14,18].…”

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confidence: 99%

Malabsorption in Skin Diseases

Berndt¹

1970

Digestion

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“…In den letzten 5 Jahren wurde wiederholt über charakteristische mor phologische Dünndarmschleimhautveränderungen bei der Dermatitis her petiformis Duhring berichtet, welche Krankheit klinisch öfters mit einem Malabsorptionssyndrom einhergeht [2,11,12,14,15,21,23,24,32,33,37,38], Diese Veränderungen der Darmmukosa gleichen auffallend denen, die bei der Zöliakie bzw. idiopathischen Steatorrhoe der Erwachsenen gefunden werden [28], Bei der Zöliakie hat man als Ursache der Darmläsionen den schädlichen Effekt von Getreidekleberprotein (Gliadin) erkannt [10].…”

Section: Introductionunclassified

“…Beide Bedingungen sind teilweise auch bei der Duhring-Enteropathie erfüllt [14,15,33,37], Unter mehrmonatiger gliadinfreier Diät besserte sich nach diesen Autoren bei der Mehrzahl der Duhring-Patienten die Malabsorp tionssymptomatik. Allerdings sind auch Fälle beschrieben, die auf eine glutenfreie Diät nicht angesprochen haben [33].…”

Section: Introductionunclassified