Effect of glycemic control on the progress of left ventricular hypertrophy and diastolic dysfunction in children with type I diabetes mellitus

Dayem, Soha M. Abd El; Battah, Ahmed A.

doi:10.5152/akd.2012.158

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…Current evidence suggests that genetic, environmental, and immunologic factors have crucial roles in the pathogenesis of T1DM, however, there are still some gaps in current knowledge (5). Impaired blood sugar control in patients with T1DM leads to structural and functional damage to the cardiovascular system, these factors predict an increased risk of cardiovascular disease (CVD) in adulthood, and studies have shown that more than 35% of people with T1DM develop vascular endothelial dysfunction after 5 years (6,7). Despite the discovery of insulin in 1921 as the main treatment for T1DM, the disease continues to be correlated with substantial medical complications associated with vascular dysfunction including retinopathy, neuropathy, nephropathy, atherosclerosis, and thrombosis in the heart, peripheral arteries, and brain.…”

Section: Introductionmentioning

confidence: 99%

Effects of omega-3 supplementation on endothelial function, vascular structure, and metabolic parameters in adolescents with type 1 diabetes mellitus: A randomized clinical trial

et al. 2022

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BackgroundVascular dysfunction is a major complication of diabetes mellitus that leads to cardiovascular disease (CVD). This study aimed to examine the effects of omega-3 consumption on endothelial function, vascular structure, and metabolic parameters in adolescents with type 1 diabetes mellitus (T1DM).MethodsIn this randomized, double-blind, placebo-controlled clinical trial, 51 adolescents (10–18 years) with T1DM completed the study. Patients received 600 mg/day [containing 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA)] of omega-3 or placebo for 12 weeks. Flow-mediated dilation (FMD), carotid intima-media thickness (CIMT), high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol, blood urea nitrogen (BUN), creatinine, fasting blood sugar (FBS), hemoglobin A1C (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), serum insulin (SI), urine albumin-creatinine ratio (uACR), blood pressure, and anthropometric indices were assessed at the baseline and after the intervention.ResultsFollowing supplementation, omega-3 significantly increased FMD (3.1 ± 4.2 vs. −0.6 ± 4%, p = 0.006) and decreased TG (−7.4 ± 10.7 vs. −0.1 ± 13.1 mg/dl, p = 0.022) in comparison with the placebo group. However, no significant difference was observed regarding CIMT (-0.005 ± 0.036 vs. 0.003 ± 0.021 mm, p = 0.33). Although hs-CRP was significantly decreased within the omega-3 group (p = 0.031); however, no significant change was observed compared to placebo group (p = 0.221). Omega-3 supplementation had no significant effect on other variables.ConclusionGiven the elevation in FMD and reduction in TG, omega-3 supplementation can improve vascular function and may reduce the risk of cardiovascular disease in adolescents with T1DM patients.

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Section: Introductionmentioning

confidence: 99%

Effects of omega-3 supplementation on endothelial function, vascular structure, and metabolic parameters in adolescents with type 1 diabetes mellitus: A randomized clinical trial

et al. 2022

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“…The LV diastolic dysfunction in patients with DM may be caused by increased LV diastolic stiffness, deposition of advanced glycation end products, and cardiac fibrosis, all as a consequence of DM (27,28). This diastolic abnormality appears related to interstitial collagen deposition and LV hypertrophy, which appear in the absence of hypertension (12,13,29).…”

Section: Discussionmentioning

confidence: 95%

“…There is evidence that metabolic disturbances, myocardial fibrosis, small vessel disease, cardiac autonomic neuropathy, and insulin resistance may all contribute to the development of diabetic cardiomyopathy (12). The relationship between myocardial hypertrophy and diastolic dysfunction and glycemic control is still a matter of debate (11,13).…”

Section: Introductionmentioning

confidence: 98%

Carotid intimal medial thickness and its relation to endothelial dysfunction and echocardiographic changes in adolescents with type 1 diabetes

Dayem

Bohy

Battah

2015

Journal of Pediatric Endocrinology and Metabolism

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“…Additionally, it has been demonstrated that failure to achieve glycemic control (decompensation) leads to deterioration in structural parameters of myocardial function [106-108]. Furthermore, a recent review on diabetes and cardiovascular disease showed the role of an intensive glycemic control in the reduction of mortality rates and risk of complications after an acute myocardial infarction or cardiac surgery in diabetic patients [109].…”

Section: Role Of Hyperglycemiamentioning

confidence: 99%

Present Insights on Cardiomyopathy in Diabetic Patients

Felício

Koury²,

Carvalho³

et al. 2016

CDR

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The pathogenesis of diabetic cardiomyopathy (DCM) is partially understood and is likely to be multifactorial, involving metabolic disturbances, hypertension and cardiovascular autonomic neuropathy (CAN). Therefore, an important need remains to further delineate the basic mechanisms of diabetic cardiomyopathy and to apply them to daily clinical practice. We attempt to detail some of these underlying mechanisms, focusing in the clinical features and management. The novelty of this review is the role of CAN and reduction of blood pressure descent during sleep in the development of DCM. Evidence has suggested that CAN might precede left ventricular hypertrophy and diastolic dysfunction in normotensive patients with type 2 diabetes, serving as an early marker for the evaluation of preclinical cardiac abnormalities. Additionally, a prospective study demonstrated that an elevation of nocturnal systolic blood pressure and a loss of nocturnal blood pressure fall might precede the onset of abnormal albuminuria and cardiovascular events in hypertensive normoalbuminuric patients with type 2 diabetes. Therefore, existing microalbuminuria could imply the presence of myocardium abnormalities. Considering that DCM could be asymptomatic for a long period and progress to irreversible cardiac damage, early recognition and treatment of the preclinical cardiac abnormalities are essential to avoid severe cardiovascular outcomes. In this sense, we recommend that all type 2 diabetic patients, especially those with microalbuminuria, should be regularly submitted to CAN tests, Ambulatory Blood Pressure Monitoring and echocardiography, and treated for any abnormalities in these tests in the attempt of reducing cardiovascular morbidity and mortality.

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Effect of glycemic control on the progress of left ventricular hypertrophy and diastolic dysfunction in children with type I diabetes mellitus

Cited by 4 publications

References 34 publications

Effects of omega-3 supplementation on endothelial function, vascular structure, and metabolic parameters in adolescents with type 1 diabetes mellitus: A randomized clinical trial

Effects of omega-3 supplementation on endothelial function, vascular structure, and metabolic parameters in adolescents with type 1 diabetes mellitus: A randomized clinical trial

Carotid intimal medial thickness and its relation to endothelial dysfunction and echocardiographic changes in adolescents with type 1 diabetes

Present Insights on Cardiomyopathy in Diabetic Patients

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