Effect of Glycerol on Peripheral Nerve: An Experimental Study

Rengachary, Setti S.; Watanabe, Itaru; Singer, P. C.; Bopp, William J.

doi:10.1227/00006123-198312000-00012

Cited by 71 publications

(44 citation statements)

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“…Alcohol inhibits neurotransmitter receptor function, an ATP-gated ion channel interacting with a small hydrophobic pocket on the receptor protein. A 30% (approximately 100 mM) ethanol solution is employed since the range of concentrations producing a nervous signal inhibition is 80-120 mM (higher than 20%) [21,33].…”

Section: Discussionmentioning

confidence: 99%

Treatment of intermetatarsal Morton?s neuroma with alcohol injection under US guide: 10-month follow-up

et al. 2004

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Morton's neuroma (MN) is a frequent cause of metatarsalgia. The aim of our study was to evaluate the efficacy of neuroma alcoholsclerosing therapy (NAST) under US guide in MN after a 10-month follow-up. Forty intermetatarsal neuromas underwent alcohol-sclerosing therapy after sonographic evaluation of their dimensions and echotexture. After subcutaneous anesthesia, a sclerosing solution composed of anesthetic (carbocaine-adrenaline 70%) and ethylic alcohol (30%) was injected inside the mass under US guidance. The procedure was repeated at intervals of 15 days until the resolution of the symptoms. A total or partial symptomatic relief was obtained in 36 cases (90%). No procedure-related complications were observed. Transitory plantar pain, due to the flogistic reaction induced by the sclerosing solution, occurred in 6 cases (15%). The 10-month follow-up revealed a 20-30% mass volume reduction and an adiposus-like change in echotexture. In the 4 cases (10%) of therapeutic failure, the preliminary sonography demonstrated a hypoechoic echotexture with a strong US beam attenuation corresponding to a highly fibrous neuroma after surgical resection. The NAST is a feasible and cost-efficient procedure with high rates of therapeutic success.

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Section: Discussionmentioning

confidence: 99%

Treatment of intermetatarsal Morton?s neuroma with alcohol injection under US guide: 10-month follow-up

et al. 2004

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“…However, it may indicate the limited neurotoxic action of glycerol on the myelinated fibers, which is discussed in the experimental literature [7,14,23,28], The regression of the reduction in superficial sensitivity in the course of time then corresponds to a decline of the edematous swelling observed morphologically [28, and Worner et al, pers. commun.j.…”

Section: Discussionmentioning

confidence: 99%

Five-and-a-Half Years' Experience with Percutaneous Retrogasserian Glycerol Rhizotomy in Treatment of Trigeminal Neuralgia

Dieckmann¹,

Bockermann²,

Heyer³

et al. 1987

Stereotact Funct Neurosurg

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The results of treating trigeminal neuralgia with percutaneous retrogang-lionic glycerol rhizotomy in 319 patients from an overall series of 394 patients with 459 operations carried out over a period of 5½years are reported. Idiopathic trigeminal neuralgia was the diagnosis in 252 patients. 34 patients had trigeminal neuralgia associated with multiple sclerosis. The remaining 33 patients suffered from symptomatic trigeminal neuralgia or atypical facial pain. 230 patients (91.3%) with idiopathic trigeminal neuralgia and 30 patients (88.2%) with multiple sclerosis reported complete freedom from pain. In 12 patients (4.8%) of those with tic douloureux and in 1 patient (2.9%) with multiple sclerosis, pain was alleviated, and the patients required a reduced pharmacotherapy. 10 patients (3.9%) and 3 patients (8.8%) were considered to be treatment failures. The rate of recurrences within the first 2 years was 10.9 and 40.0%, respectively. In the long-term, the rate of recurrences in patients with tic douloureux was 36.9%. 144 patients (45.1%) noticed a hypesthesia. 132 patients (41.4%) had hypalgesia following the procedure, and there was a decrease of symptoms in the long-term observation in 20.0% of the patients. 59 patients (18.5%) developed dysesthesia postoperatively which regressed only to an inappreciable extent in the long-term course. In 16 patients (5.0%) exclusively with a preexisting organic lesion or who had received surgical pretreatment, there was a loss of corneal sensation. The investigation showed on the one hand the effectiveness of the method, but on the other hand also the possibility of marked sensory disorder in selected cases.

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“…Anterior ethmoidal glycerol rhizotomy for vasomotor rhinitis is reported to give relief of symptoms without appreciable sensory loss [Yue, 1995]. Glycerol was applied to the surface of the nerve and the experimental results of Rengachary et al [1983] would suggest that this surprising result might be explained by limitation of damage to the circumference of the nerve. By the same argument, were the anterior ethmoidal nerve to contain the autonomic fibres they would also be partly spared.…”

Section: Ruskellmentioning

confidence: 99%

Orbital Passage of Pterygopalatine Ganglion Efferents to Paranasal Sinuses and Nasal Mucosa in Man

Ruskell¹

2003

Cells Tissues Organs

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Parasympathetic nerves of pterygopalatine ganglion origin are considered to enter the orbit and distribute to the nasal mucosa with the anterior ethmoidal nerve. As their distribution has never been demonstrated the present study was undertaken to seek evidence of their passage and to identify their relationship with the ethmoidal nerves. The soft tissues of the pterygopalatine fossa and orbit from sixteen sides of twelve cadavers were removed in one piece and either dissected or cut coronally into slabs and prepared histologically using montages of thin resin-embedded sections at intervals suitable for nerve path tracing. Several of the rami orbitales passing mediodorsally from the ganglion enter the orbit apically, branch and enter the posterior ethmoidal foramen terminating in the lining of the paranasal sinuses and others advance to enter the anterior ethmoidal canal to reach the nasal mucosa. No junctions were made with ethmoidal nerves within the orbit or the canal. Failure of surgical lesions of the anterior ethmoidal nerve as a treatment for vasomotor rhinitis may be attributed to the sparing of the separate parasympathetic nerves. Appropriate chemical lesions, on the other hand, could ensure destruction of isolated parasympathetic nerves while limiting damage to the larger anterior ethmoidal nerve.

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Effect of Glycerol on Peripheral Nerve: An Experimental Study

Cited by 71 publications

References 0 publications

Treatment of intermetatarsal Morton?s neuroma with alcohol injection under US guide: 10-month follow-up

Treatment of intermetatarsal Morton?s neuroma with alcohol injection under US guide: 10-month follow-up

Five-and-a-Half Years' Experience with Percutaneous Retrogasserian Glycerol Rhizotomy in Treatment of Trigeminal Neuralgia

Orbital Passage of Pterygopalatine Ganglion Efferents to Paranasal Sinuses and Nasal Mucosa in Man

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