Effect of Glyceryl Monocaprylate–Modified Chitosan on the Intranasal Absorption of Insulin in Rats

Gao, Mingyue; Sun, Ying; Kou, Yongqiang; Shen, Xiu; Huo, Yingnan; Liu, Chang; Sun, Zheng; Zhang, Xin; Mao, Shirui

doi:10.1016/j.xphs.2019.07.012

Cited by 13 publications

(11 citation statements)

References 37 publications

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“…Here, the TMC/FD NPs were pH sensitive and could protect insulin from degradation in the gastrointestinal tract, and TMC/FD NPs enhanced the cellular transport of insulin across the intestinal barrier [170]. The delivery of insulin by glycerol monocaprylate-modified chitosan nanoparticles has also achieved the same effects as delivery via TMC/FD NPs [171].…”

Section: Chitosan Derivative Nanoparticles For the Delivery Of Polypementioning

confidence: 96%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

654

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Section: Chitosan Derivative Nanoparticles For the Delivery Of Polypementioning

confidence: 96%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

654

326

View full text Add to dashboard Cite

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“…basic fibroblast growth factor, H102 peptide, nerve growth factor, pentapeptide, V24P peptide) can enter the brain within minutes through the transneuronal and the extraneuronal pathways [ 4 , 8 , 28 , 29 ]. When drug moieties are instilled into the nasal cavity, they can permeate across the epithelial cells located in the olfactory region of the nose and enter the brain through the cribriform plate, followed by the olfactory bulb, brain parenchyma and cranial nerves [ 4 , 6 , 28 , 32 ]. Intranasally administered drugs can also cross the BBB by reacting with receptors, allowing more drugs to be transported to the CNS with fewer peripheral side effects.…”

Section: Suitability Of Intranasal Insulin With Antidiabetic Property...mentioning

confidence: 99%

Insulin Delivery to the Brain via the Nasal Route: Unraveling the Potential for Alzheimer's Disease Therapy

Wong,

Baldelli,

Hoyos

et al. 2024

Drug Deliv. and Transl. Res.

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This comprehensive review delves into the potential of intranasal insulin delivery for managing Alzheimer's Disease (AD) while exploring the connection between AD and diabetes mellitus (DM). Both conditions share features of insulin signalling dysregulation and oxidative stress that accelerate inflammatory response. Given the physiological barriers to brain drug delivery, including the blood-brain barrier, intranasal administration emerges as a non-invasive alternative. Notably, intranasal insulin has shown neuroprotective effects, impacting Aβ clearance, tau phosphorylation, and synaptic plasticity. In preclinical studies and clinical trials, intranasally administered insulin achieved rapid and extensive distribution throughout the brain, with optimal formulations exhibiting minimal systemic circulation. The detailed mechanism of insulin transport through the nose-to-brain pathway is elucidated in the review, emphasizing the role of olfactory and trigeminal nerves. Despite promising prospects, challenges in delivering protein drugs from the nasal cavity to the brain remain, including enzymes, tight junctions, mucociliary clearance, and precise drug deposition, which hinder its translation to clinical settings. The review encompasses a discussion of the strategies to enhance the intranasal delivery of therapeutic proteins, such as tight junction modulators, cell-penetrating peptides, and nano-drug carrier systems. Moreover, successful translation of nose-to-brain drug delivery necessitates a holistic understanding of drug transport mechanisms, brain anatomy, and nasal formulation optimization. To date, no intranasal insulin formulation has received regulatory approval for AD treatment. Future research should address challenges related to drug absorption, nasal deposition, and the long-term effects of intranasal insulin. In this context, the evaluation of administration devices for nose-to-brain drug delivery becomes crucial in ensuring precise drug deposition patterns and enhancing bioavailability. Graphical Abstract Drug transport mechanism through the nose-to-brain pathway using the olfactory and trigeminal nerves (major pathway) and from the bloodstream through BBB (minor pathway).

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“…Moreover, they enhance the cellular transport of insulin across the intestinal barrier [ 78 ]. The delivery of insulin via glycerol monocaprylate-modified chitosan nanoparticles has also been demonstrated using TMC/FD NPs [ 79 ]. A nanoemulsion was coated with two different PEGylated chitosans.…”

Section: Oral Drug Delivery By Chitosan Derivativesmentioning

confidence: 99%

Surveying the Oral Drug Delivery Avenues of Novel Chitosan Derivatives

et al. 2022

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Chitosan has come a long way in biomedical applications: drug delivery is one of its core areas of imminent application. Chitosan derivatives are the new generation variants of chitosan. These modified chitosans have overcome limitations and progressed in the area of drug delivery. This review briefly surveys the current chitosan derivatives available for biomedical applications. The biomedical applications of chitosan derivatives are revisited and their key inputs for oral drug delivery have been discussed. The limited use of the vast chitosan resources for oral drug delivery applications, speculated to be probably due to the interdisciplinary nature of this research, is pointed out in the discussion. Chitosan-derivative synthesis and practical implementation for oral drug delivery require distinct expertise from chemists and pharmacists. The lack of enthusiasm could be related to the inadequacy in the smooth transfer of the synthesized derivatives to the actual implementers. With thiolated chitosan derivatives predominating the oral delivery of drugs, the need for representation from the vast array of ready-to-use chitosan derivatives is emphasized. There is plenty to explore in this direction.

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Effect of Glyceryl Monocaprylate–Modified Chitosan on the Intranasal Absorption of Insulin in Rats

Cited by 13 publications

References 37 publications

Chitosan Derivatives and Their Application in Biomedicine

Chitosan Derivatives and Their Application in Biomedicine

Insulin Delivery to the Brain via the Nasal Route: Unraveling the Potential for Alzheimer's Disease Therapy

Surveying the Oral Drug Delivery Avenues of Novel Chitosan Derivatives

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