Effect of Glycine-Zinc Complex on Mucin and IgA Expression, Secretory IgA Concentration and Lengths of Intestinal Villi in Chickens.

Bobíková, Katarína; Levkut, M.; Husáková, Eva; Levkutová, M.; Kissová, Viktória; Ivanišinová, Oksana; Grešaková, Ľubomíra; Čobanová, Klaudia

doi:10.1016/j.jcpa.2015.10.058

Cited by 4 publications

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“…Moreover, zinc is essential for cell proliferation and differentiation, especially for the regulation of DNA synthesis and mitosis [2). S o u t h o n et al [11] demonstrated that Zn deficiency in rats is accompanied On the other hand, recently published immunological parameters from that experiment [3,7] as quantification of the expression of MUC-2, IgA gene, and evaluation of secretory IgA in the lumen of the intestine, resulted in better affects found in birds fed diet supplemented with low doses of organic source of zinc.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Inorganic or Organic Zinc on the Morphology of the Intestine in Broiler Chickens

et al. 2017

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Section: Discussionmentioning

confidence: 99%

The Effect of Inorganic or Organic Zinc on the Morphology of the Intestine in Broiler Chickens

et al. 2017

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“…The mucous layer covering the intestinal epithelial cells can prevent the invasion of toxic substances, digestive enzymes and bacteria (43). Studies on pigs and chickens showed that dietary Zn supplementation could increase the content and gene expression of MUC2 in the intestine (44,45). The results showed that the contents of MUC2 in jejunum and ileum of meat ducks increased significantly with the increase of Zn-Met level, which enhanced the chemical barrier of meat ducks.…”

Section: Effects Of Zn-met On Intestinal Barrier Function Of Meat Ducksmentioning

confidence: 99%

Zinc Methionine Improves the Growth Performance of Meat Ducks by Enhancing the Antioxidant Capacity and Intestinal Barrier Function

et al. 2022

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This study was conducted to investigate the effects of zinc methionine (Zn-Met) on the growth performance, antioxidant capacity and intestinal barrier function of meat ducks. Three hundred and sixty 1-day-old male Cherry Valley ducks were randomly divided into 6 groups with 6 replicates (10 birds each), and fed diets with 0, 30, 60, 90, 120 or 150 mg/kg Zn for 35 d. The results indicated that dietary supplementation with Zn-Met substantially increased the average daily gain (ADG), and reduced the feed to gain ratio (F/G) during 1–35 d (P < 0.05). Dietary Zn-Met markedly increased the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH), and reduced the malondialdehyde (MDA) content in the jejunum (P < 0.05). The mRNA expression levels of critical antioxidant enzymes such as SOD, CAT, and nuclear factor erythroid 2-related factor 2 (Nrf2) were increased by Zn in the jejunum (P < 0.05). Supplementation with 60, 90, 120, and 150 mg/kg of Zn significantly reduced the diamine oxidase (DAO) activity in the serum (P < 0.05). Different levels of Zn can increase the mRNA expression of occluding (OCLN) and zonula occludens-1 (ZO-1) in the jejunum (P < 0.05). Diets supplemented with zinc significantly increased the content of mucin2 (MUC2), secretory immunoglobulin A (sIgA), immunoglobulin A (IgA) and immunoglobulin G (IgG) in the jejunum of meat ducks (P < 0.05). The 16S rRNA sequence analysis indicated that 150 mg/kg of Zn had a higher relative abundance of Verrucomicrobia and Akkermansia in cecal digesta (P < 0.05). In conclusion, Zn-Met improved the growth performance of meat ducks by enhancing intestinal antioxidant capacity and intestinal barrier function. This study provides data support for the application of Zn-Met in meat duck breeding.

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Effect of Zinc Supplementation on Growth Performance, Intestinal Development, and Intestinal Barrier-Related Gene Expression in Pekin Ducks

Wen

Zhao

Liu

et al. 2017

Biol Trace Elem Res

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The current study was conducted to investigate the effect of zinc supplementation on the growth performance, intestinal morphology, and the transcription of the barrier function related genes in Pekin ducks. Seven-hundred and sixty-eight 1-day-old Pekin ducks were randomly assigned into six dietary treatments. Each treatment had eight replicates with 16 ducks per replicates. The ducks were fed either a corn-soybean meal basal diet or basal diets supplemented with 15, 30, 60, 120, and 240 mg zinc/kg from zinc sulfate. This experiment lasted for 5 weeks, and the jejunum sample were harvested at 14 and 35 days of age. Results have shown that diets supplemented with zinc significantly increased the duck body weight, average daily gain, and average daily feed intake in different period of experiment (P < 0.05); feed to gain ratio was decreased as the zinc level increased (P < 0.05). Zinc supplementation increased the villus height and decreased the crypt depth in jejunum of ducks (P < 0.05) at 14 and 35 days of age. The transcription of tight junction protein CLDN1, OCND, ZO-1, and ZO-3 in jejunum were increased (P < 0.05), and the messenger RNA (mRNA) levels of leak protein CLDN2 were decreased as the dietary zinc level increased (P < 0.05) at 14 and 35 days of age. The mRNA levels of chemical barrier-related genes MUC2 and TFF-2 in jejunum at 14 and 35 days of age were increased (P < 0.05) by zinc supplementation, and so did the transcription of immunological barrier-related genes lgA, pIgR, LYZ, and AvBD2 (P < 0.05). In conclusion, dietary zinc supplementation exhibited growth-promoting effect on Pekin duck, improved intestinal morphology, and enhanced the intestinal barrier integrity.

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Effect of Glycine-Zinc Complex on Mucin and IgA Expression, Secretory IgA Concentration and Lengths of Intestinal Villi in Chickens.

Cited by 4 publications

References 0 publications

The Effect of Inorganic or Organic Zinc on the Morphology of the Intestine in Broiler Chickens

The Effect of Inorganic or Organic Zinc on the Morphology of the Intestine in Broiler Chickens

Zinc Methionine Improves the Growth Performance of Meat Ducks by Enhancing the Antioxidant Capacity and Intestinal Barrier Function

Effect of Zinc Supplementation on Growth Performance, Intestinal Development, and Intestinal Barrier-Related Gene Expression in Pekin Ducks

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