Effect of gold nanoparticles shape and dose on immunological, hematological, inflammatory, and antioxidants parameters in male rabbit

Mehanna, Eman T.; Kamel, Basma S. A.; Abo-Elmatty, Dina M.; El‐Nabtity, Sameh M.; Mahmoud, Manal B.; Abdelhafeez, Mostafa M.; Abdoon, Ahmed S.

doi:10.14202/vetworld.2022.65-75

Cited by 8 publications

(5 citation statements)

References 53 publications

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“…injection of 50 nm AuNRs did not produce any apparent toxicity in dogs. Similar results were recorded in rats [14,21], rabbits [15], and pets [16]. On the contrary, after direct exposure to naked colloidal 8 to 37 nm AuNPs, a high percentage of the mice showed loss of weight and appetite and died within 21 days [22].…”

Section: Discussionsupporting

confidence: 76%

“…ROS produced by AuNPs might induce cellular damage by destructing the proteins, DNA, membranes, and other organelles like mitochondria, and nucleus [29]. In contrast, some reports have indicated that 50 nm AuNRs showed no hepatotoxicity or nephrotoxicity in rats [14,30], rabbits [15], and pets [16]. This difference might be due to the route of administration, duration of exposure, or species difference.…”

Section: Discussionmentioning

confidence: 99%

“…Compared to other types of gold nanostructures, 50 nm nanorods (AuNRs) have a higher plasmonic photothermal effect due to the plasmon resonance absorption and scattering of light in the near-infrared region, and they are widely used in biomedical imaging, X-ray computed tomography (X-ray CT), for PTT and gene/drug delivery [13]. Injection of 50 nm AuNRs didn't produce any mortality or toxicity as indicated by animal behavior, gross morphology, blood biochemistry, hematological analysis, immunology, and histopathological examination in rats [14], rabbits [15], and pets [16]. On the other hand, when examined in vitro, 50 nm AuNRs have cytotoxic and genotoxic effects on mouse splenocytes and human normal and cancer cell lines in a dose-dependent manner [17].…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity and Genotoxicity Effects of Intravenous Injection of 50 nm Gold Nanorods (AuNRs) in Dogs

Abdoon

2023

SciBase Oncol

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity and Genotoxicity Effects of Intravenous Injection of 50 nm Gold Nanorods (AuNRs) in Dogs

Abdoon

2023

SciBase Oncol

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“…The findings indicated improved sperm quality, testosterone concentration, and nutrient digestibility in male rabbits. At the same time, similar to the NPs used, high serum antioxidant defense potential was proven in gold nanorods in the experiment by Mehanna et al (2022).…”

Section: Discussionmentioning

confidence: 65%

Effect of Gadolinium Orthovanadate Nanoparticles on Male Rabbits' Reproductive Performance under Oxidative Stress

Koshevoy¹,

Naumenko²,

Skliarov³

et al. 2022

WVJ

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Oxidative stress as a leading factor of male infertility requires correction with modern pharmacological agents, particularly redox-active nanoparticles, to improve sperm quality and hormonal balance. The current experimental study aimed to investigate the effect of orthovanadate nanoparticles of rare earth elements, particularly Gadolinium, with pronounced redox properties on the reproductive function of male rabbits under oxidative stress. A total of 36 mature male Hyla rabbits were divided into three groups of intact control (n = 12) and two experimental groups, including rabbits ubder oxidative stress (n = 12), induced by the introduction of tert-Butyl hydroperoxide, and those under oxidative stress plus hydrosol of gadolinium orthovanadate nanoparticles (NPs, n = 12) intake for 14 days. There were four rabbits per three replicates in each group. Animals of all groups were kept on the same diet and had free access to water. The use of NPs led to an improvement in sperm quality indicators. There was an improvement in motility and ejaculate volume indicators (by 14.6% and 39.2%, respectively), a reduction of the content of morphologically abnormal sperm by 26.7%; normalization of sex hormones, an increase in the level of total testosterone (by 113%) with a decrease in 17-β-estradiol (by 16.5%). This sex hormones improvement led to an increase in the androgen saturation of the rabbit’s body (free androgen index at the end of the experiment was 36.5%). The obtained changes were accompanied by a decrease in the oxidative load, as evidenced by a reduced content of diene conjugates and thio-barbituric acid-reactive compounds in the blood serum of rabbits by 30.4% and 26.8%, compared to the control. At the same time, there was an increase in the antioxidant potential, especially its glutathione link – the activity of glutathione peroxidase and glutathione reductase (by 42.5% and 34.2%, respectively), and the content of reduced glutathione increased by 62.3%, compared to the indicators before the introduction of NPs. The results of the study confirmed the effectiveness of using gadolinium orthovanadate NPs to correct the reproductive function of males under oxidative stress.

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“…AuNP therapy reduced elevated levels of nitrite, free radicals, and sulfhydryl in the brain caused by okadaic acid [209]. Additionally, it has been observed that this therapy improves the levels of catalase, glutathione, and superoxide dismutase, which are important antioxidant enzymes involved in cellular defense mechanisms [205,209,210].…”

Section: Application Of Gold-based Nps (Aunps) and Their Antioxidant ...mentioning

confidence: 99%

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Patel,

Kevadiya,

Bajwa

et al. 2023

Antioxidants

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Oxidative stress is a deteriorating condition that arises due to an imbalance between the reactive oxygen species and the antioxidant system or defense of the body. The key reasons for the development of such conditions are malfunctioning of various cell organelles, such as mitochondria, endoplasmic reticulum, and Golgi complex, as well as physical and mental disturbances. The nervous system has a relatively high utilization of oxygen, thus making it particularly vulnerable to oxidative stress, which eventually leads to neuronal atrophy and death. This advances the development of neuroinflammation and neurodegeneration-associated disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy, dementia, and other memory disorders. It is imperative to treat such conditions as early as possible before they worsen and progress to irreversible damage. Oxidative damage can be negated by two mechanisms: improving the cellular defense system or providing exogenous antioxidants. Natural antioxidants can normally handle such oxidative stress, but they have limited efficacy. The valuable features of nanoparticles and/or nanomaterials, in combination with antioxidant features, offer innovative nanotheranostic tools as potential therapeutic modalities. Hence, this review aims to represent novel therapeutic approaches like utilizing nanoparticles with antioxidant properties and nanotheranostics as delivery systems for potential therapeutic applications in various neuroinflammation- and neurodegeneration-associated disease conditions.

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Effect of gold nanoparticles shape and dose on immunological, hematological, inflammatory, and antioxidants parameters in male rabbit

Cited by 8 publications

References 53 publications

Cytotoxicity and Genotoxicity Effects of Intravenous Injection of 50 nm Gold Nanorods (AuNRs) in Dogs

Cytotoxicity and Genotoxicity Effects of Intravenous Injection of 50 nm Gold Nanorods (AuNRs) in Dogs

Effect of Gadolinium Orthovanadate Nanoparticles on Male Rabbits' Reproductive Performance under Oxidative Stress

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

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