Effect of Gossypol on Human Testicular Function: Evaluation of Seminal and Hormonal Parameters

Frick, J.; Danner, Ch.

doi:10.1007/978-1-4613-2809-4_3

Cited by 9 publications

(14 citation statements)

References 4 publications

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“…A significant reduction in sperm motility was detected in all subjects, accompanied by severe oligospermia (Coutinho and Melo, 1988). The antispermatogenic effect of gossypol was in one study reported to be fully reversible after termination of treatment (Frick and Danner, 1985); another study reported irreversibility in 10-20% of treated men (Mellinger and Goldstein, 1987). Some men receiving a dose of 20 mglday remained azoospermic 2 years following discontinuation of the drug (Coutinho et al, 1985;Coutinho and Melo, 1988;Meng, 1988).…”

Section: Clinical Studiesmentioning

confidence: 97%

“…Spermatozoa, spermatids, and spermatocytes of mid-and late stages were identified as gossypol target cells by some investigators (Coutinho et al, 1985;Frick and Danner, 1985;Kalla et al, 1985a;Liu et al, 1985;Ahluwalia et al, 1986;Fei and Teng, 1988;Hoffer et al, 1988;Teng and Fei, 1988;Ueno et al, 1988). These cells were the most susceptible to damage by gossypol, the first to show detectable change, and the first to degenerate.…”

Section: Spermicidal Effects Of Gossypolmentioning

confidence: 99%

“…Other species tested seem to be more sensitive to the generalized toxic effects of gossypol (Frick and Danner, 1985;Heywood, 1988;Wang et al, 1988). Various tissues and cell types respond differently to gossypol as revealed by autoradiographic studies in rats (Xue, 1985;Stumpf et al, 1988).…”

Section: Effects On the Seminiferous Epitheliummentioning

confidence: 99%

“…There are studies reporting that gossypoI has the potential to lower sperm counts and suppress sperm motility without changing the hormonal balance and libido levels (Frick and Danner, 1985;Kalla et al, 1985a;Liu et al, 1985). On the other hand, some Chinese studies have reported high rates of altered libido among Beijing participants, whereas very low rates were found among Nanjing participants (Liu et al, 1985).…”

Section: Poratmentioning

confidence: 99%

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Effects of gossypol on the motility of mammalian sperm

Porat

1990

Molecular Reproduction Devel

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Section: Clinical Studiesmentioning

confidence: 97%

Section: Spermicidal Effects Of Gossypolmentioning

confidence: 99%

Section: Effects On the Seminiferous Epitheliummentioning

confidence: 99%

Section: Poratmentioning

confidence: 99%

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Effects of gossypol on the motility of mammalian sperm

Porat

1990

Molecular Reproduction Devel

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“…Although plants have been used to control the fertility of male and female partners since ancient time, the discovery of gossypol (isolated from the cotton plant, Gossypium species) as a male contraceptive by Chinese scientists probably forced scientists to investigate other medicinal plants with antifertility effects [3]. In the recent past, a variety of preparations and active principles from different parts of the plants like seeds, stem, leaves, flowers, root or stem barks, etc.…”

Section: Introductionmentioning

confidence: 99%

Reversible Contraceptive Potential of Harad in Male Albino Mice

Gupta¹

2016

Int J Pharm Pharm Sci

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Objective: Developing a male contraceptive of plant origin has always been of great interest among researchers. The aim of present investigation was to evaluate the contraceptive potential of Terminalia chebula R. (Harad) with respect to dose and reversibility in male albino mice.Methods: Aqueous bark extract of Harad was administered orally at 100 (G III), 300 (G IV) and 500 (G V) mg/kg b.w. to males for 35 d, and the effect on histology of testis and accessory sex organs, enzymes 3ß-and 17ß-HSDs, SOD, catalase and LPO levels, sialic acid and fructose levels, sperm parameters, serum testosterone and fertility parameters was determined. Toxicological and recovery studies (G VI and VII) were also carried out.Results: Harad-treated mice showed dose-related histological alterations in reproductive organs with reductions in weights, the height of germinal epithelium, germ cell number and diameter of stage VII tubules, along with adverse effect on biochemical and sperm parameters compared to controls. No alterations were noticed in SOD, catalase and LPO levels, though, mice in G V showed an increased LPO level. Libido was not affected, but fertility suppressed significantly in Harad-treated males (G VI) compared to controls. However, 42 d after treatment withdrawal, alterations in reproductive end points and fertility recovered to control levels. Body and organ weights, histo-architecture of vital organs, levels of ALT, AST and creatinine, and hematological parameters remained unchanged. Conclusion:The results suggest that Harad causes dose-dependent reversible contraception in mice without any toxicity.

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Genotoxic effects of gossypol acetic acid on cultured murine erythroleukemia cells

Majumdar

Daly

Kleemeyer

et al. 1991

Environ and Mol Mutagen

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Gossypol acetic acid, a male anti-fertility drug, was evaluated for its effects on cell multiplication, chromosomes, scheduled and unscheduled DNA synthesis, and the surface ultrastructure in cultured murine erythroleukemia cells (clone 6A11A). Gossypol treatments inhibited cell multiplication at 10 and 20 micrograms/ml concentrations and this inhibitory effect increased with elevated dosage and prolonged treatment. Gossypol significantly depressed the mitotic index but did not alter chromosome numbers or increase the frequency of chromosomal structural abnormalities. Cell fraction techniques revealed that gossypol induced a negative effect on cellular DNA synthesis at concentrations as low as 3.3 micrograms/ml after 24 hr of treatment. The number of cells undergoing DNA synthesis decreased with increasing dosages and durations of drug exposure. An unscheduled DNA synthesis assay (UDS) found gossypol to be an active UDS-inducing agent at certain dose levels and treatment times, as measured by increase in net nuclear gain and percentage of UDS cells (ANOVA, Bonferroni test, P less than 0.05). A scanning electron microscope study revealed that 10 micrograms/ml treatment with gossypol caused changes in mouse erythroleukemia cell surface ultrastructure characterized by general balding and the appearance of holes, often after 48 hr of treatment.

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Effect of Gossypol on Human Testicular Function: Evaluation of Seminal and Hormonal Parameters

Cited by 9 publications

References 4 publications

Effects of gossypol on the motility of mammalian sperm

Effects of gossypol on the motility of mammalian sperm

Reversible Contraceptive Potential of Harad in Male Albino Mice

Genotoxic effects of gossypol acetic acid on cultured murine erythroleukemia cells

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