Effect of GPi DBS on functional imaging of the brain in dystonia

Yianni, John; Bradley, Kevin M.; Soper, Nigel; O’Sullivan, Valerie; Nandi, Dipankar; Gregory, Ralph; Stein, John; Aziz, Tipu Z.

doi:10.1016/j.jocn.2004.05.010

Cited by 18 publications

(11 citation statements)

References 22 publications

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“…This plasticity often is assumed to be occurring within the basal ganglia, but it may also occur in distance regions. In fact, the effect of pallidal DBS on regional blood flow provides evidence for distant reorganization, as obvious changes are detectable in the cerebral cortex, cerebellum, and elsewhere (Detante et al, 2004; Thobois et al, 2008; Yianni et al, 2005). Additional limitations of the neurosurgical literature include the application of multiple terms that differ from conventional agreements (e.g.…”

Section: A Reappraisal Of the Evidencementioning

confidence: 99%

The functional neuroanatomy of dystonia

Neychev

Gross

Lehericy

et al. 2011

Neurobiology of Disease

400

419

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Dystonia is a neurological disorder characterized by involuntary twisting movements and postures. There are many different clinical manifestations, and many different causes. The neuroanatomical substrates for dystonia are only partly understood. Although the traditional view localizes dystonia to basal ganglia circuits, there is increasing recognition that this view is inadequate for accommodating a substantial portion of available clinical and experimental evidence. A model in which several brain regions play a role in a network better accommodates the evidence. This network model accommodates neuropathological and neuroimaging evidence that dystonia may be associated with abnormalities in multiple different brain regions. It also accommodates animal studies showing that dystonic movements arise with manipulations of different brain regions. It is consistent with neurophysiological evidence suggesting defects in neural inhibitory processes, sensorimotor integration, and maladaptive plasticity. Finally, it may explain neurosurgical experience showing that targeting the basal ganglia is effective only for certain subpopulations of dystonia. Most importantly, the network model provides many new and testable hypotheses with direct relevance for new treatment strategies that go beyond the basal ganglia.

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Section: A Reappraisal Of the Evidencementioning

confidence: 99%

The functional neuroanatomy of dystonia

Neychev

Gross

Lehericy

et al. 2011

Neurobiology of Disease

400

419

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show abstract

“…It may act through the normalization of the altered pallidal output and progressive restoration of the cortical and brainstem loops involved in motor control (15). In fact, two recent studies using functional imaging of the brain, the one using positron emission tomography (9) and the other using SPECT (10), revealed hyperactivation of motor cortex areas in patients with dystonia, which was reversed with effective GPi DBS. To the best of our knowledge, our study is the first to report normalization in brain SPECT imaging during the ‘on‐DBS’ state in TD, correlated with significant motor improvement.…”

Section: Discussionmentioning

confidence: 99%

“…Brain perfusion scintigraphy using single photon emission computed tomography (SPECT) provides well‐established means of studying regional cerebral blood flow (CBF) in humans in vivo (8). Although functional imaging studies of dystonic patients have been performed, very few have focused at the functional effects of treatments (9, 10). Brain SPECT may prove to be a useful tool for investigating the discrete effects of DBS on neural systems.…”

Section: Introductionmentioning

confidence: 99%

A double-blind study on a patient with tardive dyskinesia treated with pallidal deep brain stimulation

Kefalopoulou

Paschali

Markaki

et al. 2009

Acta Neurologica Scandinavica

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“…Although this study comprises a single human report, these changes induced by DBS will be reproducible in the future. A substantial number of PET studies have previously demonstrated that DBS in OCD, dystonia, depression or PD reversed the metabolic activity or cerebral blood flow toward the normal baseline [158][159][160][161][162][163][164].…”

Section: Chronic Responses: Plasticity and Remodelingmentioning

confidence: 99%

Deep Brain Stimulation: The Perspective of Brain Connectivity

Kim¹

2016

From Bench to Bedside - Trauma, Tumors, Spine, Functional Neurosurgery

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Deep brain stimulation (DBS) has been demonstrated as a treatment option to alleviate patient symptoms in movement disorders, such as Parkinson's disease (PD) and dystonia, and has emerged as an alternative treatment for medically intractable epilepsy. However, complete understanding of the mechanism of DBS remains elusive despite recent human and nonhuman studies that have provided mechanistic clues. The precise mechanisms of action for DBS remain unclear. This review provides an up-to-date overview of the detailed procedures of DBS and reviews the actions of DBS on brain networks. Studies regarding the structural and functional connectivity of the brain are also reviewed.

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Effect of GPi DBS on functional imaging of the brain in dystonia

Cited by 18 publications

References 22 publications

The functional neuroanatomy of dystonia

The functional neuroanatomy of dystonia

A double-blind study on a patient with tardive dyskinesia treated with pallidal deep brain stimulation

Deep Brain Stimulation: The Perspective of Brain Connectivity

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