Effect of granulocyte-macrophage colony-stimulating factor inducer on left ventricular remodeling after acute myocardial infarction

Maekawa, Yuichiro; Anzai, Toshihisa; Yoshikawa, Tsutomu; Sugano, Yasuo; Mahara, Keitaro; Kohno, Takashi; Takahashi, Toshiyuki; Ogawa, Satoshi

doi:10.1016/j.jacc.2004.05.083

Cited by 112 publications

(82 citation statements)

References 30 publications

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“…For RT-PCR analysis, pats were sacrificed at 3 hours, 6 hours, 12 hours, 1 day, 2 days, 7 days, 14 days, or 28 days post-MI and sham-operated rats served as controls (n=6 at each time point). In vivo ischemia and reperfusion (I/R) was induced as we previously described [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Experimental Myocardial Infarctionmentioning

confidence: 99%

“…Toeda et al, Versican expression in myocardial infarction 11 To test that GM-CSF induced inflammatory cytokine release in PBMC, we finally examined the production of inflammatory cytokines, IL-6 and MCP-1, in GM-CSF-stimulated PBMC by ELISA. GM-CSF induced both IL-6 and MCP-1 in PBMC in a dose-dependent manner ( Fig.…”

Section: Gm-csf Induced Cytokine Production In Human Pbmcmentioning

confidence: 99%

“…Recently, GM-CSF was reported to facilitate infarct expansion in association with the promotion of monocyte recruitment [11]. However, the molecular mechanism by which this cytokine affects the infarcted heart is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Versican is induced in infiltrating monocytes in myocardial infarction

et al. 2005

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Abbreviations: bp, base pairs; hr, hours; kbp, kilo base pairs; min, minutes; RNA, ribonucleic acid; sec, seconds Toeda et al, Versican expression in myocardial infarction 2 AbstractVersican, a large chondroitin sulfate proteoglycan, plays a role in conditions such as wound healing and tissue remodeling.To test the hypothesis that versican is transiently expressed and plays a role in the infarcted heart, we examined its expression in a rat model of myocardial infarction.Northern blot analysis demonstrated increased expression of versican mRNA. Quantitative real-time RT-PCR analysis revealed that versican mRNA began to increase as early as 6 hours and reached its maximal level 2 days after coronary artery ligation. Versican mRNA then gradually decreased, while the mRNA of decorin, another small proteoglycan, increased thereafter. gene by monocytes in the infarcted heart. We suggest that upregulation of versican in the infarcted myocardium may have a role in the inflammatory reaction, which mediates subsequent chemotaxis in the infarcted heart.

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Section: Experimental Myocardial Infarctionmentioning

confidence: 99%

Section: Gm-csf Induced Cytokine Production In Human Pbmcmentioning

confidence: 99%

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Versican is induced in infiltrating monocytes in myocardial infarction

et al. 2005

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“…Moreover, MCSF is a marker of inflammation, this finding reinforce the hypothesis that inflammation is the common pathway of ACS, which mainly differs in the degree of thrombosis, that may be occlusive and persistent leading to STEMI or transient leading to NSTEMI and not in the pathophysiological background. (22) …”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes after drug-eluting stent implantation for unprotected left main coronary artery disease

Pollice¹,

Pollice²,

Jacob³

2013

ejcm

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SummaryObjective: Stenosis in the unprotected left main coronary artery (ULMCA) is considered a standard indication for surgical revascularization. Some studies have demonstrated that stenting of the ULMCA is safe and feasible in selected patients. Drug eluting stents (DES) have been shown to be superior to bare metal stents (BMS) in reducing restenosis and major adverse cardiac events (MACE) both in-hospital and at follow-up after treatment of ULMCA disease. Several studies showed that the mid-term prognosis of patients with left main stenting is good, but most of them are limited by small populations and the availability of mid-term results. Thus, we sought to evaluate the very long term impact of DES vs BMS in a large cohort of patients undergoing stent implantation for ULMCA disease in our center. Material and Method:Between June 2002 and June 2008 a total of 354 consecutive patients with ULMCA stenosis were treated with percutaneous coronary intervention with BMS (53 patients) or DES (301 patients) implantation. A multivariable adjustment was provided in order to account for baseline differences between groups. Results:The average clinical follow-up was 551±512 days. Overall, MACE rate was significantly lower in the DES group (16.6% vs 26.4%, P=0.02). The beneficial effect was driven by a reduction of death (6.0% vs 9.4%, P=0.11), MI (2.7% vs 3.8%, P=0.33) and target vessel revascularization after DES implantation (9.0 % vs 15.1%, P=0.11). After correcting for independent predictors of adverse events, the adjusted hazard ratios (HRs) for the risk of mortality and myocardial infarction after DES implantation relative to BMS implantation were 0.99 (95% CIs 0.30-3.21, P=0.98) and 0.59 (95% CIs 0.01-3.45, P=0.56), respectively. The adjusted HR for two-year MACE was 0.50 (95 CIs 0.25-1.02), P=0.056, mainly driven by a statistical significant reduction of TVR ], P=0.018]. Conclusion:Patients presenting with ULMCA disease, who are treated with DES have a significant reduction in the rate of target lesion revascularization with no increased risk of death or myocardial infarction.Keywords: Stroke, bare metal stents, drug eluting stents.

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“…Several studies have demonstrated that GM-CSF promotes the infiltration of monocytes and macrophages after tissue injury (34,35). Furthermore, GM-CSF mRNA and protein synthesis occurs in both monocytes and endothelial cells as a result of direct cell-to-cell interaction (36).…”

Section: Discussionmentioning

confidence: 99%

Granulocyte Macrophage Colony-Stimulating Factor Expression by Both Renal Parenchymal and Immune Cells Mediates Murine Crescentic Glomerulonephritis

Timoshanko

Kitching

Semple

et al. 2005

Journal of the American Society of Nephrology

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Effect of granulocyte-macrophage colony-stimulating factor inducer on left ventricular remodeling after acute myocardial infarction

Abstract: The GM-CSF induction by romurtide facilitated infarct expansion in association with the promotion of monocyte recruitment and inappropriate collagen synthesis in the infarcted region during the early phase of MI.

Cited by 112 publications

References 30 publications

Versican is induced in infiltrating monocytes in myocardial infarction

Versican is induced in infiltrating monocytes in myocardial infarction

Clinical outcomes after drug-eluting stent implantation for unprotected left main coronary artery disease

Granulocyte Macrophage Colony-Stimulating Factor Expression by Both Renal Parenchymal and Immune Cells Mediates Murine Crescentic Glomerulonephritis

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