Effect of growth hormone on vitamin D metabolism

Spanos, E.; Barrett, Doreen; MacIntyre, I.; Pike, J. Wesley; Safilian, E. F.; Haussler, Mark R.

doi:10.1038/273246a0

Cited by 172 publications

(46 citation statements)

References 17 publications

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“…GH has been shown to restore the formation of 1,25-(OH) 2 D 3 which is reduced by hypophysectomy in rats (10)(11)(12). Treatment with rat GH normalized the conversion of 25-OHD 3 to 24,25-(OH) 2 D 3 , which was markedly increased in hypophysectomized rats (12).…”

Section: Introductionmentioning

confidence: 99%

Local action of exogenous growth hormone and insulin-like growth factor-I on dihydroxyvitamin D production in LLC-PK1 cells

Tanaka

Seino

1998

European Journal of Endocrinology

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Previous in vivo studies have shown that growth hormone (GH) affects vitamin D and mineral metabolism. Insulin-like growth factor-I (IGF-I) was recently reported to be a regulator of renal 1,25-dihydroxyvitamin D 3 (1,25-(OH) 2 D 3 ) production, suggesting that it mediates the effects of GH on vitamin D metabolism. However, there is no direct evidence to support this. The present study was designed to investigate the in vitro effects of GH and IGF-I on the renal production of 1,25- (OH) produced were determined after lipid extraction and HPLC purification. Production of 1,25-(OH) 2 D 3 and 24,25-(OH) 2 D 3 was increased after both IGF-I and GH preincubation in a dose-dependent manner. Significant increases were found after preincubation with 13 nmol/l IGF-I (1,25-(OH) 2 D 3 , 1.8-fold; 24,25-(OH) 2 D 3 , 1.5-fold) or 0.9 or 9 nmol/l GH (1,25-(OH) 2 D 3 , 1.3-fold and 1.5-fold; 24,25-(OH) 2 D 3 , 1.4-fold and 1.5-fold respectively). Furthermore, the effect of 9 nmol/l GH on 1,25-(OH) 2 D 3 and 24,25-(OH) 2 D 3 production was blocked in the presence of IGF-I receptor monoclonal antibody. These results confirm that IGF-I acts on renal tubules, resulting in induction of 1,25-(OH) 2 D 3 and 24,25-(OH) 2 D 3 production, and the findings suggest that GH stimulates 1,25-(OH) 2 D 3 and 24,25-(OH) 2 D 3 production by increasing local IGF-I production in the kidney.

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Section: Introductionmentioning

confidence: 99%

Local action of exogenous growth hormone and insulin-like growth factor-I on dihydroxyvitamin D production in LLC-PK1 cells

Tanaka

Seino

1998

European Journal of Endocrinology

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“…An elevation of serum levels of la, 25-dihydroxyvitamin D has been reported in lactating rats (10). Estrogens (11), prolactin (12), parathyroid hormone (13), and growth hormone (14) …”

Section: Introductionmentioning

confidence: 99%

Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation.

Kumar¹,

et al. 1979

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“…Ceci a été démontré chez le rat (Fleet et al, 1994) et chez le porc (Denis ef al, 1994). Comme la stimulation de l'absorption calcique (Bruns et al, 1983 ;Wongsurawat et al, 1984 ;Yeh et Aloia, 1984), celle de l'absorption phosphatée pourrait égale-ment résulter d'une synthèse accrue de calcitriol sous GH (Spanos ef al, 1978). Néan-moins, la stimulation par GH de la captation de P par une lignée entérocytaire (CaCo-2) in vitro est indépendante des concentrations en calcitriol du milieu, mais proportionnelle à celles d'IGF-1 (Fleet et al, 1994 (Guéguen, 1963(Guéguen, , 1965Young et al, 1966a et b ;Compère et al, 1967 ;Boxebeld et al, 1983 ;Braithwaite, 1984a ;Challa et al, 1989) Yano et al, 1991 ;Care, 1994 (Tomas et al, 1967 ;Scott et Beastall, 1978).…”

Section: Autres Influences Hormonalesunclassified