Effect of Growth Hormone on Plasma Unesterified Fatty Acid Levels of Hypophysectomized Rats

Engel, Howard; Hallman, Lois F.; Siegel, Sidney; Bergenstal, Delbert M.

doi:10.3181/00379727-98-24173

Cited by 92 publications

(6 citation statements)

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“…Both in vitro [20] and in vivo [21] experiments have shown that changing NEFA concentrations can alter pituitary hormone secretion in pigs. Both in humans and dog, it was shown that the plasma NEFA level increases after administration of growth hormone [22], NEFA in turn can block growth hormone secretion [23]. Thus, in general, we observe that enriched functional categories often have a physiological interpretation.…”

Section: Discussionmentioning

confidence: 67%

Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues

et al. 2011

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BackgroundEndocrine tissues play a fundamental role in maintaining homeostasis of plasma metabolites such as non-esterified fatty acids and glucose, the levels of which reflect the energy balance or the health status of animals. However, the relationship between the transcriptome of endocrine tissues and plasma metabolites has been poorly studied.MethodsWe determined the blood levels of 12 plasma metabolites in 27 pigs belonging to five breeds, each breed consisting of both females and males. The transcriptome of five endocrine tissues i.e. hypothalamus, adenohypophysis, thyroid gland, gonads and backfat tissues from 16 out of the 27 pigs was also determined. Sex and breed effects on the 12 plasma metabolites were investigated and associations between genes expressed in the five endocrine tissues and the 12 plasma metabolites measured were analyzed. A probeset was defined as a quantitative trait transcript (QTT) when its association with a particular metabolic trait achieved a nominal P value < 0.01.ResultsA larger than expected number of QTT was found for non-esterified fatty acids and alanine aminotransferase in at least two tissues. The associations were highly tissue-specific. The QTT within the tissues were divided into co-expression network modules enriched for genes in Kyoto Encyclopedia of Genes and Genomes or gene ontology categories that are related to the physiological functions of the corresponding tissues. We also explored a multi-tissue co-expression network using QTT for non-esterified fatty acids from the five tissues and found that a module, enriched in hypothalamus QTT, was positioned at the centre of the entire multi-tissue network.ConclusionsThese results emphasize the relationships between endocrine tissues and plasma metabolites in terms of gene expression. Highly tissue-specific association patterns suggest that candidate genes or gene pathways should be investigated in the context of specific tissues.

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Section: Discussionmentioning

confidence: 67%

Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues

et al. 2011

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“…Gamma oscillations are linked to binding processes [10,11] and information transfer between cortical areas [12]. Synchrony in the gamma band may bias the routing of pain-related signals toward limbic structures, which are involved in emotional processing, monitoring, and descending control of pain [19].…”

Section: Discussionmentioning

confidence: 99%

The influence of music and music therapy on pain-induced neuronal oscillations measured by magnetencephalography

Hauck

Metzner

Rohlffs

et al. 2013

Pain

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Modern forms of music therapy are clinically established for various therapeutic or rehabilitative goals, especially in the treatment of chronic pain. However, little is known about the neuronal mechanisms that underlie pain modulation by music. Therefore, we attempted to characterize the effects of music therapy on pain perception by comparing the effects of 2 different therapeutic concepts, referred to as receptive and entrainment methods, on cortical activity recorded by magnetencephalography in combination with laser heat pain. Listening to preferred music within the receptive method yielded a significant reduction of pain ratings associated with a significant power reduction of delta-band activity in the cingulate gyrus, which suggests that participants displaced their focus of attention away from the pain stimulus. On the other hand, listening to self-composed "pain music" and "healing music" within the entrainment method exerted major effects on gamma-band activity in primary and secondary somatosensory cortices. Pain music, in contrast to healing music, increased pain ratings in parallel with an increase in gamma-band activity in somatosensory brain structures. In conclusion, our data suggest that the 2 music therapy approaches operationalized in this study seem to modulate pain perception through at least 2 different mechanisms, involving changes of activity in the delta and gamma bands at different stages of the pain processing system.

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“…A rapid loss of fat from the depots and its temporary accumulation in the liver follow injections of adrenaline and noradrenaline (Clément, 1951 ;Wadström, 1957;Aujard, 1953), extracts of whole anterior pituitary (Best & Campbell, 1936) and purified preparations of growth hormone (GH) (Li, Simpson & Evans, 1949; Greenbaum, 1953), adrenocorticotrophic hormone (ACTH) (Li et al 1949; Astwood, Raben, Rosenberg & Westermeyer, 1953) or thyroid stimulating hormone (TSH) (Dobyns, 1946), the activity of the last two being at least partly independent of their trophic effects on the adrenal and thyroid glands respectively. Formerly, it was thought that the mobilized fat left the depots predominantly as triglycéride (Greenbaum & McLean, 1953), but more recent studies have suggested that only small quantities leave in this form (Reshef, Shafrir & Shapiro, 1958;Engel, Hallman, Siegel & Bergenstal, 1958). The fat mobilizing activities of these hormones, therefore, may be due in part to their effect in increasing the quantity of FFA leaving the depots.…”

Section: Introductionmentioning

confidence: 95%

The Stimulating Effects of Adrenaline and Anterior Pituitary Hormones on the Release of Free Fatty Acids From Adipose Tissue

Buckle¹

1962

Journal of Endocrinology

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The quantity of free fatty acids (FFA) released from rat epididymal fat pads in vitro and their concentration within the tissue were determined. The addition of adrenaline, adrenocorticotrophic hormone (ACTH), thyroid stimulating hormone (TSH) and growth hormone (GH) each increased the release of FFA, and their respective minimum effective concentrations were 0\m=.\125,0\m=.\004,0\m=.\5 and 1\m=.\25 \g=m\g./ml. of medium. In every case, the increased release of FFA was associated with a rise in the quantity present within the pads, and the amount released closely paralleled their concentration within the tissue.

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Effect of Growth Hormone on Plasma Unesterified Fatty Acid Levels of Hypophysectomized Rats

Cited by 92 publications

References 0 publications

Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues

Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues

The influence of music and music therapy on pain-induced neuronal oscillations measured by magnetencephalography

The Stimulating Effects of Adrenaline and Anterior Pituitary Hormones on the Release of Free Fatty Acids From Adipose Tissue

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