Effect of growth hormone-releasing factor infusion on somatotropin, prolactin, thyroxine, insulin, insulin-like growth factor I and blood metabolites in control and somatostatin-immunized growing pigs

Dubreuil, Pascal; Petitclerc, D.; Gaudreau, Pierrette; Brazeau, Paul; Pelletier, G.

doi:10.1016/0739-7240(91)90066-s

Cited by 14 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Insulin is an anabolic hormone promoting glucose uptake by tissues. Strong evidences suggested that circulating insulin level could be elevated by GHRH and GH treatment in pigs (Walton et al, 1987;Gopinath and Etherton, 1989;Kirkwood et al, 1989;Dubreuil et al, 1991;Johnson et al, 1990;Klindt et al, 1995). In the current study, the improvement in serum insulin concentration may be ascribed to the higher level of GH in pigs fed betaine.…”

Section: Discussioncontrasting

confidence: 41%

Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine

Huang

Han

et al. 2006

Livestock Science

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 41%

Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine

Huang

Han

et al. 2006

Livestock Science

View full text Add to dashboard Cite

“…Although we have no data about the GH level in NMA fed pigs, many previous researches reported that intravenous treatment of pigs with NMA significantly increased GH secretion in vitro and in vivo (Barb et al, 1993(Barb et al, , 1996Estienne et al, 1996bEstienne et al, , 1998Estienne et al, , 2000a. Moreover, strong evidences suggested that circulating insulin level could be elevated by growth hormone releasing factor and GH treatment in pigs (Walton et al, 1987;Gopinath et al, 1989;kirkwood et al, 1989;Johnson et al, 1990;Dubreuil et al, 1991;Klindt et al, 1995). Insulin is an anabolic hormone with potent effects on muscle protein metabolism.…”

Section: Discussionmentioning

confidence: 91%

Growth Associated Hormones Response and Fat Metabolism Change in Finishing Pigs Fed with n-Methyl-d, L-Aspartate

Xu¹,

Xu²,

Xiao³

2002

Asian Australas. J. Anim. Sci

View full text Add to dashboard Cite

A trial was conducted to investigate the effect of dietary NMA on several growth associated hormones and fat metabolism in finishing pigs. A total of 84 crossbred finishing pigs (average initial BW of 56±0.37 kg) were divided into 6 pens, 14 pigs per pen (7 gilts and 7 barrows per pen). 3 pens of pigs were fed with control diet (corn-soybean meal) and the others were fed control diet addition with 50 mg/kg NMA. During the trial, all pigs were given free access to feed and water. After 44 days trial, 8 pigs from each treatment (4 gilts and 4 barrows, weight similar to average group weight, 86.94±0.71 kg for control group, and 90.55±1.51 kg for NMA treated group) were sacrificed to collect the sample of the liver, longissimus muscle, subcutaneous fat (10th rib). The addition of NMA in diet increased the IGF-I, Insulin, T3, T4 levels in serum by 50.68% (p<0.05), 38.36% (p<0.05), 123.33% (p<0.01), 60.58% (p<0.03), respectively. Meanwhile, IGF-I level in the liver and the muscle were increased with 17.83% (p<0.03) and 26.00% (p<0.03) with addition of NMA. The data from subcutaneous fat (10th rib) analysis showed that supplement of 50 mg/kg NMA decreased the total activities of malic dehydrogenase (MDH) by 20.54% (p<0.05), glucose-6-phosphate dehydrogenase (G-6-DPH) by 16.97% (p<0.05), and decreased the specific activities of MDH and G-6-DPH by 37.46% (p<0.01) and 35.06% (p<0.01), respectively. The hormone sensitive lipase (HSL) total activity was increased by 25.00% (p<0.05) in NMA treated pigs. These results indicated that addition of 50 mg/kg NMA to diet can induce the endocrine great change in finishing pigs, furthermore, inhibit the fat synthesis through suppressing lipogenic enzymes and promote the fat degradation by elevating HSL activity in finishing pigs.

show abstract

“…Moreover, in the report of Vance et al (1989), infusion of GHRH (10 ng/kg/min) for 14 days increases plasma IGF-1 concentrations from day 3 and it seems plateau until day 14 of treatment in GH-deficient boys. In contrast, continuous administration of GHRH increased the concentration of IGF-1 during period of treatment in swine and cows (Dubreuil et al, 1991;Vanderkool et al, 1995). In normal rats, infusion of GHRP-6 (100 µg/kg BW) for 14 days decreased plasma IGF-1 concentrations (Thomas et al, 2000).…”

Section: Discussionmentioning

confidence: 95%

Effect of Twice Daily Administration of GH-releasing Peptide-2 for 10 Days on Growth Performance, Plasma GH Responses and Insulin-like Growth Factor-1 Concentrations in Swine

Nou¹,

Inoue²,

Lee³

et al. 2003

Asian Australas. J. Anim. Sci

View full text Add to dashboard Cite

An increase in frequency of administration of exogenous growth hormone (GH) or GH-releasing hormone was reported to be a model to increase blood circulating insulin-like growth factor-1 (IGF-1) and to improve growth performance in animals. We have investigated the effect of twice daily administration of GH-releasing peptide-2 (GHRP-2) on growth performance, GH responsiveness and plasma insulin-like growth factor IGF-1 in swine. We administered to eight swine, 3 control and 5 treatment, a twice daily s.c. injections of GHRP-2 (30 µg/kg BW) for a period of 10 days. Every day blood samples immediately taken before injections of GHRP-2 or saline, at 08:00 h and 16:00 h, were measured for IGF-1 concentrations. Blood samples for GH assay were collected every 20 min on days 1, 6 and 10, from 1 hour before and 3 h after GHRP-2 or saline injections at 08:00 h. GH peak concentrations and GH area under curve (GH AUC) on day 1, 6 and 10 in treatment group of swine were higher than those in control swine (p<0.05). Twice daily administration of GHRP-2 caused a significantly attenuation (p<0.05) of GH peak concentrations (80.25±13.87, 39.73±5.72 and 27.57±6.06 ng/ml for day 1, 6 and 10, respectively) and GH AUCs (3,536.15±738.35, 1,310.31±203.55 and 934.37±208.99 ng/ml for day 1, 6 and 10, respectively). However, there was no significant difference in GH peak concentration and GH AUC between day 6 and 10. Plasma IGF-1 concentration levels were higher in treatment than control group of swine (p<0.05) after 3 days of the treatment, and the levels reached a plateau from day 3 to 10 of experiment. Growth performance did not alter by GHRP-2 administration, even though a numerical increase of body weight gain and feed efficiency was observed. These results indicate that twice daily administration of GHRP-2 for 10 days in swine did not significantly influence on growth performance, caused an overall attenuation of GH response, and that elevation of plasma GH concentrations caused by GHRP-2 administration increased plasma IGF-1 concentrations, even though an attenuation of GH response was observed.

show abstract

Effect of growth hormone-releasing factor infusion on somatotropin, prolactin, thyroxine, insulin, insulin-like growth factor I and blood metabolites in control and somatostatin-immunized growing pigs

Cited by 14 publications

References 40 publications

Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine

Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine

Growth Associated Hormones Response and Fat Metabolism Change in Finishing Pigs Fed with n-Methyl-d, L-Aspartate

Effect of Twice Daily Administration of GH-releasing Peptide-2 for 10 Days on Growth Performance, Plasma GH Responses and Insulin-like Growth Factor-1 Concentrations in Swine

Contact Info

Product

Resources

About