Effect of growth hormone replacement on wound healing in healthy older men

Papadakis, Maxine A.; Hamon, Greg; Stotts, Nancy A.; Tierney, Mary Jo; Spencer, E. Martin; Scheuenstuhl, Heinz; Hunt, Thomas K.

doi:10.1046/j.1524-475x.1996.40405.x

Cited by 16 publications

(7 citation statements)

References 27 publications

(32 reference statements)

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“…The well-known anabolic actions of GH have also led to use in patients in severe catabolic states, such as surgery[12], trauma[13], burns[14], intestinal fistula[15] and short bowl syndrome[16],[17]. GH has been also used to overcome apparent resistance and reverse protein catabolism that leads to muscle weakness, impaired wound healing[18] and immune responses[19],[20], resulting in increased mortality. But data from Japan suggested a possibly increased risk of leukemia in children treated with GH.…”

Section: Discussionmentioning

confidence: 99%

Growth hormone receptor expression in human primary gastric adenocarcinoma

et al. 2012

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The aim of this study was to determine the expression of growth hormone receptor (GHR) in patients with primary gastric adenocarcinoma. We investigated 48 specimens of primary gastric adenocarcinoma and their corresponding normal gastric mucosa. Immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) were used to detect the expression of GHR. Immunohistochemical analyses revealed that GHR was expressed in human primary gastric adenocarcinoma (36/48, 75.0%) and appeared to be upregulated, compared to the normal mucosa (28/48, 58.3%, P < 0.001). A significant correlation was found between GHR expression and tumor stage (P < 0.001) and tumor differentiation (P < 0.001). The average positive rate of ki-67 in GHR-positive tumors was 16.06%, while the positive rate in GHR-negative tumors was 6.17% (P < 0.01). The average apoptosis index (AI) of GHR-positive tumors was 3.36%, which was significantly lower than that (7.33%) of GHR-negative tumors. In addition, 27 of 48 cases of tumors had GHR mRNA expression, while only 17 of all 48 cases of normal mucosa did so. Our results indicate that the frequency of GHR was significantly higher in primary gastric adenocarcinoma than that in normal gastric mucosa. GHR expression was significantly correlated with tumor differentiation and tumor grade. This finding supported a possible role of growth hormone in primary gastric adenocarcinoma pathophysiology.

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Section: Discussionmentioning

confidence: 99%

Growth hormone receptor expression in human primary gastric adenocarcinoma

et al. 2012

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“…Some studies demonstrated an increase in muscle mass, but not in muscle strength, others have shown an increase in both muscle mass and strength after administration of GH supplementation [347, 348]. In addition, the combination of GH replacement and exercise training does not improve the effects brought by exercise alone [349].…”

Section: Intervention Strategies To Counteract Disability Associatmentioning

confidence: 99%

Interaction Between Bone and Muscle in Older Persons with Mobility Limitations

Ferrucci¹,

Baroni²,

Ranchelli³

et al. 2014

CPD

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Aging is associated with a progressive loss of bone-muscle mass and strength. When the decline in mass and strength reaches critical thresholds associated with adverse health outcomes, they are operationally considered geriatric conditions and named, respectively, osteoporosis and sarcopenia. Osteoporosis and sarcopenia share many of the same risk factors and both directly or indirectly cause higher risk of mobility limitations, falls, fractures and disability in activities of daily living. This is not surprising since bones adapt their morphology and strength to the long-term loads exerted by muscle during anti-gravitational and physical activities. Non-mechanical systemic and local factors also modulate the mechanostat effect of muscle on bone by affecting the bidirectional osteocyte-muscle crosstalk, but the specific pathways that regulate these homeostatic mechanisms are not fully understood. More research is required to reach a consensus on cut points in bone and muscle parameters that identify individuals at high risk for adverse health outcomes, including falls, fractures and disability. A better understanding of the muscle-bone physiological interaction may help to develop preventive strategies that reduce the burden of musculoskeletal diseases, the consequent disability in older persons and to limit the financial burden associated with such conditions. In this review, we summarize age-related bone-muscle changes focusing on the biomechanical and homeostatic mechanisms that explain bone-muscle interaction and we speculate about possible pathological events that occur when these mechanisms become impaired. We also report some recent definitions of osteoporosis and sarcopenia that have emerged in the literature and their implications in clinical practice. Finally, we outline the current evidence for the efficacy of available anti-osteoporotic and proposed anti-sarcopenic interventions in older persons.

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“…1996 ;4 :297-303 -(see Fu et al). 1996 ;4 :381-5 Tierney MJ (see Papadakis et al). 1996 ;4 :421-5 Tintle T (see Mulder et al).…”

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confidence: 99%