Effect of gum arabic-modified alginate on physicochemical properties, release kinetics, and storage stability of liquid-core hydrogel beads

Tsai, Fu-Hsuan; Kitamura, Yutaka; Kokawa, Mito

doi:10.1016/j.carbpol.2017.07.031

Cited by 61 publications

(36 citation statements)

References 44 publications

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“…polymer that shrinks in acidic conditions and swells in high-pH environments, respectively (Tsai et al, 2017). The combination of glucomannan with alginate reduced the release and swelling of the encapsulant in pH 1.2.…”

Section: Iron Releasementioning

confidence: 99%

“…Alginate is an unbranched negative charge polysaccharide consisting of 1,4-linked β-d-mannuronic (M residues) and β-l-guluronic acids (G residues) that is commonly isolated from brown algae and bacteria such as Pseudomonas aeruginosa (Tsai et al, 2017). This biopolymer is widely used in both foods and medicines due to its nontoxicity, biocompatibility, biodegradability, and ease of gelation (Zeeb et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Modification of glucomannan of Amorphophallus oncophyllus as an excipient for iron encapsulation performed using the gelation method

Wardhani

Aryanti

Etnanta

et al. 2019

Acta Sci Pol Technol Aliment

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Background. Performing iron fortification by adding the iron compound directly into foods helps to tackle the problem of iron deficiency. However, the fortification brings about some problems as well, including undesirable organoleptic effects, oxidation, and reduced bioavailability. Ensuring appropriate encapsulation can overcome these problems. Hence, it is crucial to identify a proper excipient for protecting the iron. Glucomannan has the potential to be a suitable iron encapsulation excipient. The present work therefore sought to prepare an iron excipient from modified glucomannan using the gelation method. Glucomannan modification was conducted by either chemical reaction or in combination with another compound. Materials and methods. Glucomannan was isolated from Amorphophallus oncophyllus flour. To maximize encapsulation performance, glucomannan was modified by either deacetylation using NaOH (0.4 M) or in combination with alginate. After dissolving the excipient (1%), this solution was mixed with FeSO 4 to obtain 25 mg of iron per 1 g of excipient. The mixture was dropped into either an ethanol or CaCl 2 solution for gelation. The beads of seven variations of the resultant glucomannan-based excipient were investigated for their encapsulation efficiency, bead size, and swelling. The release of iron in the two pH solutions together with their respective release models were also evaluated. Results. It was revealed that the highest iron efficiency (64%) was achieved using deacetylated glucomannan, which was gelled in CaCl 2. However, this matrix also resulted in the highest release rate in both pH solutions. The release rate of iron was lower in the low pH solution (pH: 1.2) than in the higher pH solution (pH: 6.8) for all matrix combinations. The Korsmeyer model was the most fitting model for describing the release profile of iron in both pH solutions (R 2 ≥ 0.958) for all excipient variations. Conclusion. This study suggested the potency of modified glucomannan to be pH-sensitive for iron encapsulation.

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Section: Iron Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modification of glucomannan of Amorphophallus oncophyllus as an excipient for iron encapsulation performed using the gelation method

Wardhani

Aryanti

Etnanta

et al. 2019

Acta Sci Pol Technol Aliment

View full text Add to dashboard Cite

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“…When two solutions were mixed, polyelectrolyte complexation was occurred immediately between the positive charge groups of CS and the negatively charged groups of NaA in a mild condition. Utilizing this complexation property, NaA/CS complexes have been fabricated in the form of nanoparticles, microbeads, multilayers, and porous scaffolds …”

Section: Introductionmentioning

confidence: 99%

Simple fabrication of inner chitosan‐coated alginate hollow microfiber with higher stability

Liu

Wang

et al. 2019

J Biomed Mater Res

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Sodium alginate (NaA) has been widely used as microfiber‐based scaffold material. However, Ca‐alginate microfiber might disintegrate in the physiological environment due to the loss of calcium ions, which will limit its long‐term application in tissue engineering. In this work, to enhance the stability of Ca‐alginate microfiber in the physiological environment, an inner chitosan coating was introduced to Ca‐alginate hollow microfiber by one step via a microfluidic device. A more stable composite microfiber with double cross‐linking layers was generated. The stability of the microfiber was studied in the PBS solution (pH 7.4) to identify the coating effect on the hollow structure. The results revealed that chitosan component bonded an NaA layer to form a stable polyelectrolyte complex membrane in the inner wall of the microfiber, which stabilized the hollow region even though the Ca‐alginate shell was disintegrated by PBS solution. In addition, the introduction of chitosan coating improved the inner environment of the low affinity of alginate to cell surfaces and facilitated the cell adhesion and culture in the microfiber. HepG2 cells in the microfibers displayed favorable cell viability and proliferation ability. We believe that this work will lead to the development of innovative methodologies and materials for both cell culture and tissue engineering application. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2527–2536, 2019.

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“…Moreover, some types of hydrogels exhibit specific outstanding characteristics, such as good biocompatibility, biodegradation, tunable mechanical properties, and good elasticity . Therefore, they are widely applied in the biomedical studies, such as tissue engineering, drug/gene vehicles, and wound dressing …”

Section: Introductionmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including porosity, adhesion, and stiffness. These properties are considered important factors affecting cell proliferation and tissue regeneration. Meanwhile, drug delivery and cell delivery are the two main strategies to improve the therapeutic effects of chitosan‐based hydrogels, but the choices of cells or drugs are quite varied and largely depend on the specificity of the treated tissues. The present review summarizes the physicochemical properties of chitosan‐based hydrogels and their influences on cells, and lists specific ways to promote the tissue regeneration in different systems of the human body. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47235.

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Effect of gum arabic-modified alginate on physicochemical properties, release kinetics, and storage stability of liquid-core hydrogel beads

Cited by 61 publications

References 44 publications

Modification of glucomannan of Amorphophallus oncophyllus as an excipient for iron encapsulation performed using the gelation method

Modification of glucomannan of Amorphophallus oncophyllus as an excipient for iron encapsulation performed using the gelation method

Simple fabrication of inner chitosan‐coated alginate hollow microfiber with higher stability

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

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