Effect of Habitual Khat Chewing on Glycemic Control, Body Mass Index, and Age at Diagnosis of Diabetes in Patients with Type 2 Diabetes Mellitus in Yemen

Al-Sharafi, Butheinah A.; Gunaid, Abdallah A.

doi:10.4137/cmed.s26045

Cited by 28 publications

(26 citation statements)

References 17 publications

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“…Many people chew it on a daily basis, mostly in the afternoon and evening periods, and among our patients (mostly from Sana'a and the surrounding areas), khat chewing was only mildly affected by the war among the patients coming to our clinic, with 94.9% of the males and 87.5% of the females who were khat chewers before the war continuing to chew khat after the war, even though their income had decreased. In our study, the numbers of patients who chewed khat before the war was similar to what we had shown in a previous study, with over 50% of the females and almost 80% of the males being regular chewers [23]. Most of the patients that continued to follow up in our clinic after the war started were probably better off economically than the patients who discontinued follow up, since this was a private clinic where patients had to pay for the doctor's visit.…”

Section: Discussionsupporting

confidence: 90%

The Effect of War on the Control of Diabetes in Patients with Type 2 Diabetes Mellitus in Yemen: A Cross-Sectional Study

Al-Sharafi¹,

Al-Tahami²

2017

Endocrinol Metab Syndr

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Section: Discussionsupporting

confidence: 90%

The Effect of War on the Control of Diabetes in Patients with Type 2 Diabetes Mellitus in Yemen: A Cross-Sectional Study

Al-Sharafi¹,

Al-Tahami²

2017

Endocrinol Metab Syndr

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“…19 However, two studies carried out in Yemen found that khat chewing increased the blood glucose levels in patients with T2DM. 15,18…”

Section: Khat and Glycemic Controlmentioning

confidence: 99%

“…14 There is growing evidence of the effect of khat chewing on T2DM and glycemic control. [15][16][17][18][19] However, the role of khat chewing in T2DM is not fully understood. Up to our knowledge, very few published papers have tried to draw a conclusion about khat chewing and it effect on T2DM and glycemic control.…”

Section: Introductionmentioning

confidence: 99%

Khat Chewing and Type 2 Diabetes Mellitus

Badedi

Darraj

Hummadi

et al. 2020

DMSO

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Objective: Knowledge about the effects of khat chewing on type 2 diabetes mellitus (T2DM) development and glycemic control is very sparse. Emerging data suggest that khat chewing may increase the risk of T2DM occurrence. Therefore, this study aimed to measure the prevalence of khat chewing in Saudi people with T2DM in Jazan, Saudi Arabia and to determine the association of khat chewing with T2DM development and glycemic control in T2DM. Methods: This is an analytical, cross-sectional study that included 472 Saudi participants selected randomly from primary healthcare centers in Jazan, Saudi Arabia. A chi-square test and logistic regression were performed in the statistical analysis. Results: The prevalence of khat chewing in Saudi patients with T2DM in Jazan was 29.3%. After adjusting for covariates, khat chewing was significantly associated with T2DM (odds ratio 3.5), indicating that khat chewers had a more than three times higher risk of developing T2DM than those who do not chew khat. However, there was no association between khat chewing and glycemic control in T2DM. Conclusion: Khat chewing was highly prevalent in Saudi people with T2DM in Jazan, Saudi Arabia. There was an association between khat chewing and the development of T2DM. Establishing the causal association of khat chewing with T2DM development and glycemic control and clarifying the biological role of khat in T2DM are important aims for future studies.

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“…However, khat chewers with type-2 diabetic mellitus showed higher mean body weight compared to non-chewer diabetic patients [83] . Data from both cross-sectional studies lacked previous nutritional history as well as family history of obesity.…”

Section: Khat and Obesitymentioning

confidence: 99%

Khat (Catha edulis) and Obesity: A Scoping Review of Animal and Human Studies

et al. 2016

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Background: Khat (Catha edulis) is a plant that is deeply rooted in the cultural life of East African and Southwestern Arabian populations. Prevalent traditional beliefs about khat are that the plant has an effect on appetite and body weight. Summary: This review assesses the accumulated evidences on the mutual influence of monoamines, hormones and neuropeptides that are linked to obesity. A few anti-obesity drugs that exert their mechanisms of action through monoamines are briefly discussed to support the notion of monoamines being a critical target of drug discovery for new anti-obesity drugs. Subsequently, the review provides a comprehensive overview of central dopamine and serotonin changes that are associated with the use of khat or its alkaloids. Then, all the studies on khat that describe physical, biochemical and hormonal changes are summarised and discussed in depth. Conclusion: The reviewed studies provide relatively acceptable evidence that different khat extracts or cathinone produces changes in terms of weight, fat mass, appetite, lipid biochemistry and hormonal levels. These changes are more pronounced at higher doses and long durations of intervention. The most suggested mechanism of these changes is the central action that produces changes in the physiology of dopamine and serotonin. Nonetheless, there are a number of variations in the study design, including species, doses and durations of intervention, which makes it difficult to arrive at a final conclusion about khat regarding obesity, and further studies are necessary in the future to overcome these limitations.

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Effect of Habitual Khat Chewing on Glycemic Control, Body Mass Index, and Age at Diagnosis of Diabetes in Patients with Type 2 Diabetes Mellitus in Yemen

Cited by 28 publications

References 17 publications

The Effect of War on the Control of Diabetes in Patients with Type 2 Diabetes Mellitus in Yemen: A Cross-Sectional Study

The Effect of War on the Control of Diabetes in Patients with Type 2 Diabetes Mellitus in Yemen: A Cross-Sectional Study

<p>Khat Chewing and Type 2 Diabetes Mellitus</p>

Khat (<b><i>Catha edulis</i></b>) and Obesity: A Scoping Review of Animal and Human Studies

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