Effect of Haemodilution on Transfusion Requirements in Liver Resection

Sejourne, Patrick; Jl, Meakins; Smadja, Claude; Poirier, Annie; Chamieh, F.; Grange, D; Franco, Dominique

doi:10.1016/s0140-6736(89)91978-8

Cited by 49 publications

(22 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fresh frozen plasma was used in patients with Child-Pugh grade B disease. None of the patients received intraoperative haemodilution 11 , intraoperative blood salvage 12 or autologous blood transfusion 13 -15 .…”

Section: Methodsmentioning

confidence: 99%

Autologous blood storage before hepatectomy for hepatocellular carcinoma with underlying liver disease

Itamoto

Katayama

Nakahara

et al. 2003

British Journal of Surgery

View full text Add to dashboard Cite

Background: Preoperative autologous blood donation has been suggested for patients with liver disease who are to undergo liver resection. The aim of this retrospective study was to clarify the risk factors for increased blood loss and the need for blood transfusion during hepatectomy for hepatocellular carcinoma (HCC).Methods: From January 1996 to December 2000, 206 consecutive patients, 98·5 per cent of whom had underlying liver disease, underwent elective hepatectomy for HCC.Results: Major hepatectomy was performed in 34 patients (16·5 per cent) and minor hepatectomy in 172 patients (83·5 per cent). The mean blood loss was 410 (median 260) ml. Eleven (5·3 per cent) of the 206 patients received blood transfusion during or after the operation. Operation time (P = 0·004) and central venous pressure (CVP) (P = 0·041) were independently correlated with blood loss of more than 1000 ml. Only preoperative haemoglobin level (P = 0·001) was independently correlated with the need for blood transfusion. Conclusion:In patients with underlying liver disease, maintaining CVP at a level below 5 cmH 2 O during parenchymal transection to reduce blood loss is more important than reserving autologous blood before the operation.

show abstract

Section: Methodsmentioning

confidence: 99%

Autologous blood storage before hepatectomy for hepatocellular carcinoma with underlying liver disease

Itamoto

Katayama

Nakahara

et al. 2003

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…4,7,14 The liver cut surface was packed with oxidized regenerated cellulose (Surgicel, Johnson-Johnson Co, Arlington, Tex) after hemostasis. Total vascular exclusion technique, 15 hypothermia, 1 intraoperative hemodilution, 8 cell saver, 1 and autologous blood transfusion 9 were not used. Operative blood loss was estimated as the sum of the blood absorbed from gauzes and from suctionings.…”

Section: Methodsmentioning

confidence: 99%

Prediction and Limitation of Hepatic Tumor Resection Without Blood Transfusion in Cirrhotic Patients

Kang²,

Ho³

et al. 1998

Arch Surg

View full text Add to dashboard Cite

show abstract

“…Strategies to minimize the risks of allogeneic blood transfusion are leukocyte-depleted transfusions, short storage time and the use of autologous blood transfusion. Methods for autologous transfusion used in liver surgery include preoperative blood donation [19,45,46,47], intraoperative acute normovolemic hemodilution [48], and intraoperative blood salvage [49, 50]. However, these methods are not common clinical practice yet because of logistical reasons in preoperative blood donation or the required training of the operating team in intraoperative hemodilution.…”

Section: Conclusion and Perspectives For The Futurementioning

confidence: 99%

Impact of Blood Loss on Outcome after Liver Resection

Boer¹,

Molenaar²,

Porte³

2007

Dig Surg

139

View full text Add to dashboard Cite

Partial liver resections are the treatment of choice for patients with a malignant liver or bile duct tumor. The most frequent indications for partial liver resections are colorectal metastasis, hepatocellular carcinoma (HCC) and cholangiocarcinoma. Liver resection is the only therapy with a chance for cure in these patients. Refinements in surgical technique and increasing experience have contributed to a reduction in perioperative morbidity and mortality in recent years. Despite these improvements, partial liver resections remain a major surgical procedure and carry the risk for excessive blood loss and a subsequent need for blood transfusion. Blood transfusions have been associated with systemic side effects, such as depression of the immune system. Several studies have suggested that perioperative blood loss or transfusions have a negative impact on postoperative outcome. However, it has been debated whether this is due to a real cause-effect relationship or merely the result of more complicated surgery. We have reviewed the literature concerning studies focusing on the relationship between blood loss and blood transfusion during liver surgery for malignant tumors and postoperative outcome. Most studies were based on a retrospective analysis of single center experiences, using uni- and multivariate statistical methods. Most studies have demonstrated a significant and clinically relevant association between blood transfusion and postoperative mortality and morbidity, especially postoperative infectious complications. The effect of blood transfusions on tumor recurrence and more long-term mortality is much less clear and evidence varies depending on the type of malignancy. The strongest indication that blood transfusion may have an impact on tumor recurrence has been found for patients with early stages of HCC. However, overall, no such effect could be demonstrated for patients undergoing partial liver resection for late stages of HCC, colorectal liver metastasis or cholangiocarcinoma.

show abstract

Effect of Haemodilution on Transfusion Requirements in Liver Resection

Cited by 49 publications

References 19 publications

Autologous blood storage before hepatectomy for hepatocellular carcinoma with underlying liver disease

Autologous blood storage before hepatectomy for hepatocellular carcinoma with underlying liver disease

Prediction and Limitation of Hepatic Tumor Resection Without Blood Transfusion in Cirrhotic Patients

Impact of Blood Loss on Outcome after Liver Resection

Contact Info

Product

Resources

About