Effect of halometasone cream combined with Simiao pill on the therapeutic effect and expression of serum leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP) in patients with eczema, and the factors influencing its clinical efficacy

Cao, Jun; Liu, Hui; Ding, Xiaojie

doi:10.21037/apm-21-2685

Cited by 1 publication

(6 citation statements)

References 17 publications

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“…Our previous study confirmed that combination of SMP and halomethasone cream in AD treatment could have favorable therapeutic efficacy with tolerable side effects. 4 …”

Section: Discussionmentioning

confidence: 99%

“… 3 Our previous study showed favorable outcomes in AD treatment with SMP combined with topical halometasone ointment. 4 The potential molecular and cellular mechanisms of SMP in suppressing itch are poorly defined. Previous studies indicated that increased levels of circulating EOS were parallel with degree of clinical symptoms in AD.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study confirmed that combination of SMP and halomethasone cream in AD treatment could have favorable therapeutic efficacy with tolerable side effects. 4 In this study, we explored the relationship between inflammatory indicators and EASI or PP-NRS. Dynamic changes of these indicators were also assessed during treatment.…”

Section: Discussionmentioning

confidence: 99%

“… 3 Our previous study demonstrated that administration of halomethasone cream combined with SMP for 4 weeks had a better therapeutic efficacy with good tolerance, when compared with halomethasone cream alone in AD patients. 4 Major side effects observed were pain in limbs and digestive system symptoms including mild nausea. All of these side effects were gone after 2 weeks of withdrawal.…”

Section: Introductionmentioning

confidence: 99%

“… 14 Our previous study revealed the significant relationship between concentrations of serum LTB4 and TSLP and therapeutic effects in AD patients. 4 Nevertheless, the precise assessment of the transition of these two parameters during treatment for AD was not conducted.…”

Section: Introductionmentioning

confidence: 99%

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Association of Inflammatory Indicators and Clinical Signs and Itch in Atopic Dermatitis Patients Treated with Simiao Pill Combined with Halomethasone Cream

Cao,

Liu,

Ding

2023

JIR

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Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by symptoms such as itchiness, scaling, and erythema. Previous studies have suggested that inflammatory indicators obtained from peripheral blood cell count can serve as markers for atopic dermatitis pruritus and severity. The objective of this study was to investigate whether these indicators are associated with treatment efficacy in AD patients who received a combination of halomethasone cream and Simiao pill (SMP). Methods 131 adult patients diagnosed with AD between January 2020 to August 2022 and treated with topical halometasone ointment combined with oral Simiao pill for a month were recruited and clinical dates of patients were collected. Inflammatory indicators included Eosinophil-to-lymphocyte ratio (ELR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), serum leukotriene B4 (LTB4), and thymic stromal lymphopoietin (TSLP) and clinical indexes for assessing eczema area and severity index (EASI) and peak pruritus-numerical rating scale (PP-NRS). Relationship of baseline and changes of these Inflammatory indicators and that of clinical indexes were analyzed. Results ELR, NLR, LTB4, and TSLP levels have positive association with EASI before treatment, and baseline ELR and LTB4 levels have positive relationship with PP-NRS. ELR, NLR, LTB4, and TSLP showed a significant decrease at week 2 and the low levels were maintained until week 8 after treatment, while no significant changes were observed in levels of MLR and PLR. There was a significant correlation between the decrease of ELR and the decreases of EASI and PP-NRS at weeks 2, 4 and 8 of the treatment. Conclusion ELR may serve as an effective and convenient indicator in assessing the disease severity and efficacy of SMP therapy for AD.

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“…Our previous study confirmed that combination of SMP and halomethasone cream in AD treatment could have favorable therapeutic efficacy with tolerable side effects. 4 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association of Inflammatory Indicators and Clinical Signs and Itch in Atopic Dermatitis Patients Treated with Simiao Pill Combined with Halomethasone Cream

Cao,

Liu,

Ding

2023

JIR

Self Cite

View full text Add to dashboard Cite

show abstract

Effect of halometasone cream combined with Simiao pill on the therapeutic effect and expression of serum leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP) in patients with eczema, and the factors influencing its clinical efficacy

Cited by 1 publication

References 17 publications

Association of Inflammatory Indicators and Clinical Signs and Itch in Atopic Dermatitis Patients Treated with Simiao Pill Combined with Halomethasone Cream

Association of Inflammatory Indicators and Clinical Signs and Itch in Atopic Dermatitis Patients Treated with Simiao Pill Combined with Halomethasone Cream

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