Effect of Halothane Anesthesia on the Human Cortical Visual Evoked Response

Uhl, Richard R.; Squires, Kenneth C.; Bruce, Dickson D.; Starr, Arnold

doi:10.1097/00000542-198010000-00001

Cited by 63 publications

(15 citation statements)

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“…15) Additionally, the FVEP amplitude and latency fluctuated with changes in the patient's consciousness level, 2,8,14) and non-specific pathways such as the limbic system or reticular formation interfered with the FVEP. 15) FVEPs are cortical responses with a long tract, compared to subcortical responses such as auditory brainstem responses or short latency somatosensory evoked potentials, so are easily affected by anesthesia, 13) blood pressure, and body temperature. 10) In the clinical setting, highly fluctuating amplitudes and latencies with unknown causes and FVEP findings not corresponding to postoperative visual function have been observed.…”

Section: Introductionmentioning

confidence: 99%

Optic Nerve Evoked Potentials Elicited by Electrical Stimulation-Experimental and Clinical Studies-

Kikuchi

Sasaki

Matsumoto

et al. 2005

Neurol. Med. Chir.(Tokyo)

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This study investigated whether the optic nerve evoked potential (ONEP) elicited by electrical stimulation of the optic nerve can serve as a reliable intraoperative indicator of visual function. In the experimental study, two silver-ball stimulating electrodes were placed on the dog optic nerve adjacent to the apex of the orbit and one recording electrode was placed on the optic nerve near the chiasm. The nerve was stimulated with 0.1 to 10 mA rectangular pulses. Stable and reproducible ONEPs were obtained. The ONEPs were not influenced by electromyographic potentials and were recorded more clearly on the optic nerve than on the surrounding tissue. Stepwise incremental transection of the thickness of the nerve resulted in incremental amplitude reduction proportional to the transected area. No response was recorded after complete sectioning of the nerve. In the clinical study, recordings were obtained from 15 patients after craniotomy to treat parasellar tumors or cerebral aneurysms. Reproducible ONEPs were recorded intraoperatively from the electrode placed on the optic nerve near the chiasm in 14 of 15 patients. In the remaining patient, the ONEP, recorded only after tumor removal because the optic nerve was stretched and extremely thin, was remarkably small and the patient developed unilateral blindness postoperatively. These experimental and clinical results suggest the possibility of intraoperative monitoring of visual function in patients undergoing craniotomy for the treatment of lesions near the optic nerve.

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Section: Introductionmentioning

confidence: 99%

Optic Nerve Evoked Potentials Elicited by Electrical Stimulation-Experimental and Clinical Studies-

Kikuchi

Sasaki

Matsumoto

et al. 2005

Neurol. Med. Chir.(Tokyo)

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show abstract

“…FVEP has been a popular clinical index to monitor anesthesia level during surgery (Raitta et al, 1979;Uhl et al, 1980), to diagnose prechiasmal and retrochiasmal lesions (Carlin et al, 1983;Kriss et al, 1982;Markand et al, 1982;Wilson, 1978), to indicate intracranial pressure induced by head injury (McSherry et al, 1982), and to alarm brain death (Reilly et al, 1978;Trojaborg & Jorgensen 1973). FVEP can be measured in patients who have very poor visual acuity (Spehlmann, 1985), and some studies also reported that the FVEP can be measured in patients who can see flashes clearly but not pattern stimuli owing to their partial deficiencies in optical fiber connections between retina and visual cortex (Kriss et al, 1982;Wilson, 1978).…”

Section: Discussionmentioning

confidence: 99%

Brain Computer Interface Based on the Flash Onset and Offset Visual Evoked Potentials

Lee¹,

Wu²,

Shyu³

et al. 2011

Recent Advances in Brain-Computer Interface Systems

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“…There is some evidence in the literature to support that hypothesis. Increasing alveolar halothane concentration in humans results in an increased latency in the P1 peak of the cortical visual evoked potential (Uhl et al, 1980), and halothane anesthesia in rabbits affects latencies, ampli-I i Ii I Illii tudes, and wave shape of the visual evoked response (VER) (Gerritsen, 1970).…”

Section: Discussionmentioning

confidence: 99%

“…Since administration of anticholinesterase agents alters the VER in cats (Harding, Kirby, and Wiley, 1985;Harding, Wiley, and Kirby, 1983), and nonhuman primates (Woolley, 1976), the VER changes during halothane anesthesia (Uhl et al, 1980;Gerritsen, 1970) could result from cholinergic inhibition.…”

Section: Discussionmentioning

confidence: 99%