Effect of Halothane on Rat Liver Adenylate Cyclase

Bernstein, Keith J.; Verosky, Mariagnes; Triner, L.

doi:10.1213/00000539-198505000-00014

Cited by 3 publications

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“…The effects of halothane on cAMP formation have been reported by several authors using a variety of experimental paradigms. These vary from measurements of whole tissue contents after anaesthesia [31,46,66] to examining the effects on agonistdriven responses [2,4,23,54] (table V). What is clear, and in accord with previous sections, is that no consistent effects have been observed.…”

Section: Interaction Of Anaesthetic Agents With Signal Transductionmentioning

confidence: 99%

“…In neuronal tissues, halothane increases cAMP concentrations in vivo [31,46], decreases noradrenaline stimulated cAMP formation [54] or is ineffective [2]. In cardiac tissue, a general decrease is observed [23,66], whilst in the liver, halothane increases both basal and glucagon stimulated cAMP formation [4]. These experiments are attempting to mimic (or to examine directly) what would happen in vivo.…”

Section: Interaction Of Anaesthetic Agents With Signal Transductionmentioning

confidence: 99%

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Signal Transduction: G Proteins and Second Messengers

Lambert

1993

British Journal of Anaesthesia

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The mechanisms underlying receptor-effector coupling are fundamental to our understanding of cellular function. A central issue in this area is how cell surface receptors transduce and amplify incoming signals. Other articles in this issue of the Journal cover the details of Ca 2+ channel structure and their interactions with anaesthetic agents. This review concentrates on two of the most well characterized second messenger systems, adenylyl cyclase-cAMP and inositol polyphosphate-[Ca 2+ ][.

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