“…Geographically, 22 studies were conducted in Asia [ 15 , 17 , 19 , 40 , 44 – 60 ], 25 in Europe [ 8 , 9 , 16 , 38 , 40 , 43 , 61 – 75 ], and 24 in the United States [ 11 , 37 , 39 , 41 , 76 – 87 ]. 24 studies combined 5 or more main LBs [ 11 , 18 , 19 , 37 , 44 – 46 , 48 , 54 , 58 , 59 , 61 , 63 – 65 , 68 , 72 , 76 – 78 , 82 , 85 , 86 , 88 ], and 60 studies reported that combinations of LBs had at least 3 levels and each LB was assigned a score, which meet the inclusion criteria for dose–response analyses [ 8 , 9 , 11 , 15 – 19 , 37 – 52 , 55 – 60 , 62 , 63 , 65 – 68 , 70 , 71 , 73 – 75 , 78 – 81 , 86 – 89 ]. Table 1 shows the main characteristics of the included studies and Supplemental Tables 2–4 in Additional file 2 show the definition and categories ...…”