Effect of heat exposure on the activity of monoamine oxidase in the rat brain and interscapular brown adipose tissue

Cvijic̀, Gordana; Djordjević, Jelena; Petrović, Vesna; Davidović, Vesna

doi:10.1016/s0306-4565(99)00042-x

Cited by 1 publication

(2 citation statements)

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“…Changed daily rhythm of light and darkness, due to keeping the animals under the conditions of continuous light and darkness, induces a significant reduction of hypothalamic MAO-A activity (27). Exposure of animals to extreme environmental temperatures (38 °C ' for 20 and 60 minutes) provokes a decrement of total MAO activity in rat hypothalamus, brain stem and hippocampus (28,29). These changes in the brain MAO activity are accompanied by a significant increment of circulating ACTH and corticosterone concentration (28,30).…”

Section: Hypothalamic-pituitary-adrenocortical Systemmentioning

confidence: 99%

“…The intensity of its activation is evaluated by the decrement of its concentration in the tissues (47,48), increment in the circulation (49), intensification of its urinary excretion (47) and its increased release from catecholaminergic neurons in various brain regions (50). The increased catecholamine concentration in the sympathoadrenal and brain catecholaminergic systems, among others, is due to elevated activation of tyrosine-hydroxylase (TH) (51), dopamine-beta-hydroxylase (DBH) (52), phenyletanolamine-N-methyltranspherase (PNMT) (53), enzymes that are involved in catecholamine synthesis, or lowered activation of the degrading one, MAO (54).…”

Section: Sympatho-adrenomedullar Systemmentioning

confidence: 99%

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Hypothalamo-pituitary-adrenocortical and sympatho-adrenomedullar systems in stress response

Cvijic

Djordjević

2003

Jugoslav Med Biohem

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The hypothalamic-pituitary-adrenocortical and sympatho-adrenomedullar systems are major effectors systems that serve to maintain homeostasis during exposure to various stressors. The neurochemical pathways controlling activation of hypothalamic-pituitary-adrenocortical and sympatho-adrenomedullar systems are of special interest. Catecholamines present in specific brain areas as well as in peripheral tissues are responsible for adequate stress response regulating the relationships between the hypothalamic-pituitary-adrenocortical and sympatho-adrenomedullar functions. In last decade, numerous studies have demonstrated differential sympathoneural and adrenomedullary responses during exposure to different stressors. Some stressors provoke the strongest reaction of adrenocortical activity than that of adrenomedularry, while others do the opposite. Each type of stressor has its own central neurochemical and peripheral neuroendocrine "signature" with quantitative and qualitative distinct mechanisms.

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Section: Hypothalamic-pituitary-adrenocortical Systemmentioning

confidence: 99%