Compared with traditional arc welding, ultrasonic welding of plastic structural components has such advantages as fast welding speed, high weld strength, small surface damages, simple equipment operation and cleanness and no pollution, thus having a good application prospect. However, the existing literatures have discussed little on the thermal stability analysis of the welding process and the influences of the parameters affecting the fixation effect of welding on the heat transfer performance of the welding process. For this reason, this paper analyzes the heat source in the ultrasonic welding of plastic structural components based on numerical simulation. First, numerical simulation was performed on the temperature field of the heat source in the ultrasonic welding of plastic structural components, the basic heat transfer forms in the welding process were elaborated in detail, the corresponding governing equations and boundary conditions were given and the governing equation of nonlinear transient heat conduction were solved by the finite element method. Then, ABAQUS thermal analysis and heat source parameter calibration were carried out on the welding heat source. In the experiment section, the heat source analysis results were given regarding the ultrasonic welding of plastic structural components.