Displacements of milling centres caused by thermal load is a vital issue of a present research. The Final element analysis, the computed fluid dynamic and other predicting tools are strong sources of information about thermo-mechanical behaviour of a machine. Validation and verification of a solution is required as many factors and coefficients influence the solution. The presented study describes the thermo-mechanical behaviour of a spindle of a milling centre. There is demonstrated the thermo-mechanical model and the verification is shown. Simulated data are compared with the measurement. Data generated by simulated options are processed. The goal of this processing is a sensitivity analysis of a thermo-mechanical system. Compensation of thermal displacements of machining spindles is currently a requested issue. Presented sensitivity analysis might help with identification of a critical area of a heat load. Improvements in these areas increase symmetry of warming-up, cooling and other heat distribution parameters. These thermal parameters influence structural displacements. Improvements decrease negative effects of heat loading, such as thermal dilatations and angular deviations. This approach leads to increase the quality and the performance of machining.