Effect of heat shock on courtship behavior, sound production, and learning in comparison with the brain content of LIMK1 in Drosophila melanogaster males with altered structure of the limk1 gene

Никитина, Е. А.; Kaminskaya, A. N.; Molotkov, Dmitry; Попов, А. В.; Савватеева-Попова, Е. В.

doi:10.1134/s0022093014020082

Cited by 13 publications

(7 citation statements)

References 26 publications

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“…, which has a mutation of LIM k1 that is key to actin remodeling and associated with accumulation of β-amyloid in hippocampal neurons. Heat shock reduced β-amyloid and improved learning ability (Nikitina et al 2014). …”

Section: Heat Shock Enhances Memory Synapse Function and Neuron Surmentioning

confidence: 99%

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

Hooper

Durham

Török

et al. 2016

Cell Stress and Chaperones

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Networks of neuronal synapses are the fundamental basis for making and retaining memory. Reduced synapse number and quality correlates with loss of memory in dementia. Heat shock factor 1 (HSF1), the major transcription factor regulating expression of heat shock genes, plays a central role in proteostasis, in establishing and sustaining synaptic fidelity and function, and in memory consolidation. Support for this thesis is based on these observations: (1) heat shock induces improvements in synapse integrity and memory consolidation; (2) synaptic depolarization activates HSF1; (3) activation of HSF1 alone (independent of the canonical heat shock response) augments formation of essential synaptic elementsneuroligands, vesicle transport, synaptic scaffolding proteins, lipid rafts, synaptic spines, and axodendritic synapses; (4) HSF1 coalesces and activates memory receptors in the postsynaptic dendritic spine; (5) huntingtin or α-synuclein accumulation lowers HSF1 while HSF1 lowers huntingtin and α-synuclein aggregation-a potential vicious cycle; and (6) HSF1 agonists (including physical activity) can improve cognitive function in dementia models. Thus, via direct gene expression of synaptic elements, production of HSPs that assure high protein fidelity, and activation of other neuroprotective signaling pathways, HSF1 agonists could provide breakthrough therapy for dementia-associated disease.

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Section: Heat Shock Enhances Memory Synapse Function and Neuron Surmentioning

confidence: 99%

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

Hooper

Durham

Török

et al. 2016

Cell Stress and Chaperones

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show abstract

“…For example, fluctuations in water temperature leading to Hsps production have a positive effect on memory formation in the pond snail Lymnaea stagnalis [ 91 ]. Similarly, mild HS restores memory in the D. melanogaster Volabo and Agnostic mutants that normally have learning and memory problems [ 92 , 93 ].…”

Section: Relationship Between the Stress Response System And Memorymentioning

confidence: 99%

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Zatsepina

Evgen’ev

Гарбуз

2021

Cells

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Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and universal system for protecting cells and the whole body from various types of stress. Among Hsps, the group of proteins with a molecular weight of 70 kDa (Hsp70) plays a particularly important role. These proteins are molecular chaperones that restore the native conformation of partially denatured proteins after exposure to proteotoxic forms of stress and are critical for the folding and intracellular trafficking of de novo synthesized proteins under normal conditions. Hsp70s are expressed at high levels in the central nervous system (CNS) of various animals and protect neurons from various types of stress, including heat shock, hypoxia, and toxins. Numerous molecular and behavioral studies have indicated that Hsp70s expressed in the CNS are important for memory formation. These proteins contribute to the folding and transport of synaptic proteins, modulate signaling cascades associated with synaptic activation, and participate in mechanisms of neurotransmitter release. In addition, HSF1, a transcription factor that is activated under stress conditions and mediates Hsps transcription, is also involved in the transcription of genes encoding many synaptic proteins, whose levels are increased in neurons under stress and during memory formation. Thus, stress activates the molecular mechanisms of memory formation, thereby allowing animals to better remember and later avoid potentially dangerous stimuli. Finally, Hsp70 has significant protective potential in neurodegenerative diseases. Increasing the level of endogenous Hsp70 synthesis or injecting exogenous Hsp70 reduces neurodegeneration, stimulates neurogenesis, and restores memory in animal models of ischemia and Alzheimer’s disease. These findings allow us to consider recombinant Hsp70 and/or Hsp70 pharmacological inducers as potential drugs for use in the treatment of ischemic injury and neurodegenerative disorders.

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“…First of all, a major drawback is the necessity of exposing experimental animals to high temperatures. This can lead to unwanted effects when examining phenomena influenced by temperature, such as life span, reproduction, and behavior (Lithgow et al, 1994;Hercus et al, 2003;Hill et al, 2014;Nikitina et al, 2014). Second, the response is transient, meaning transgene expression will disappear again after some time (e.g., Didomenico et al, 1982;Fortin et al, 2014), which is problematic when sustained expression within a specific time frame is desired.…”

Section: Heat Shock Promoters Enable Temperature-based Control Over Gene Expressionmentioning

confidence: 99%

Conditional gene expression in invertebrate animal models

Driesschaert

Mergan

Temmerman

2021

Journal of Genetics and Genomics

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Effect of heat shock on courtship behavior, sound production, and learning in comparison with the brain content of LIMK1 in Drosophila melanogaster males with altered structure of the limk1 gene

Cited by 13 publications

References 26 publications

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Conditional gene expression in invertebrate animal models

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