Effect of Heat Stress on Yield, Monoterpene Content and Antibacterial Activity of Essential Oils of Mentha x piperita var. Mitcham and Mentha arvensis var. piperascens

Heydari, Milad; Zanfardino, Anna; Taleei, Alireza; Bushehri, Ali Akbar Shahnejat; Hadian, Javad; Maresca, Viviana; Sorbo, Sergio; Napoli, Michela Di; Varcamonti, Mario; Basile, Adriana; Rigano, Daniela

doi:10.3390/molecules23081903

Cited by 45 publications

(26 citation statements)

References 26 publications

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“…The C. albicans growth inhibition obtained could be attributed to the high levels of monoterpenes such as menthol, menthone and 1,8-cineole in the Mentha × piperita EO we used. These monoterpenes were reported having antimicrobial activities against gram-positive and gram-negative bacteria [37,38,39]. The effects of Mentha × piperita EO on C. albicans growth reported in this study support those of other studies showing the antimicrobial activity of Mentha × piperita EO against different bacteria such as Escherichia coli and Staphylococcus aureus [40].…”

Section: Discussionsupporting

confidence: 86%

The Effects of Mentha × piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes

et al. 2019

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The rise in resistance and changes in the spectrum of Candida infections have generated enormous interest in developing new antifungal drugs using natural molecules such as plant essential oils (EOs). Antimicrobial activity against foodborne pathogenic and spoilage microorganisms has been reported for EOs. The goal of this study was to assess the effect of Mentha × piperita essential oil (EO) on C. albicans growth, transition (change from blastospore to hyphae forms), and biofilm formation as well as on the expression of certain virulent genes. We show that whole EO and its vapor attenuated the yeast’s growth, compared to that in the control. The effect of the EO was comparable to that of amphotericin-B (AmB). The EO and its vapor significantly decreased the morphological changes of C. albicans, reduced biofilm formation, and disrupted mature C. albicans biofilms. The effect produced by whole EO on biofilm formation/disruption was notably comparable to that observed with AmB. Exposure of C. albicans to EO and its vapor downregulated the expression of various genes, such as secreted aspartyl proteinases (SAP 1, 2, 3, 9, 10) and hyphal wall protein 1 (HWP1). Altogether, these results provide new insight into the efficacy of Mentha × piperita EO against C. albicans and suggest the potential of Mentha × piperita EO for use as an antifungal therapy in multiple applications.

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Section: Discussionsupporting

confidence: 86%

The Effects of Mentha × piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes

et al. 2019

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“…2), and the maximum reduction was observed at 100 mg kg −1 Ni (Table 4). A similar decline in the EO constituents was reported in the case of Mentha piperita L. and M. arvensis under heat stress (Heydari et al 2018). The other two active constituents such as menthone and menthyl acetate were considerably increased at 20 mg kg −1 of soil (Fig.…”

Section: Biochemical Attributessupporting

confidence: 82%

Alterations in photosynthetic pigments, antioxidant machinery, essential oil constituents and growth of menthol mint (Mentha arvensis L.) upon nickel exposure

et al. 2020

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The present study was conducted in view of the alarming increase in the concentration of various heavy metals like nickel, copper, lead, cadmium, and arsenic etc., in the soils globally. Little attention has been paid towards the deleterious effect of these heavy metals particularly nickel (Ni) on the performance of pharmaceutically exigent essential oil-bearing crops like menthol mint (Mentha arvensis L.). Menthol mint, a dominant essential oil-producing aromatic plant, is widely cultivated in Uttar Pradesh (India) and has wide applications in pharmaceutical industry. Nickel, an essential micronutrient and a main component of the plant enzyme urease, has vital role in plants and is required in very low amounts for normal growth and functioning of plants. In this study, Ni was applied in the form of NiCl 2 with various concentrations of 20, 40, 60, 80, and 100 mg kg −1 Ni of soil and one set was kept as control. Interestingly, Ni at 20 mg kg −1 of soil significantly enhanced all the parameters studied, including constituents of essential oil, particularly menthone and menthyl acetate content. However, a significant reduction was observed in most of the parameters studied with increasing concentrations of Ni. The growth (plant height, fresh and dry weights and herbage yield), biochemical (photosynthetic pigments, chlorophyll fluorescence and carbonic anhydrase activity), and quality parameters (content of essential oil & its active constituents) exhibited a significant reduction over 20 mg kg −1 of soil. However, the activities of enzymatic antioxidants, such as superoxide dismutase (SOD), catalase (CAT), and peroxidase (POX), and the level of proline (PRO) were enhanced at the higher concentrations of Ni. Thus, the present study confirms that Ni applied at 20 mg kg −1 of soil proved beneficial dose, whereas 100 mg kg −1 of soil produced toxic response for the overall growth and development of the mint crop.

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“…This mint is known worldwide as “Mentha of Pancalieri” or “Mint Italo-Mitcham”. In herbal medicine, it is used in the form of the green plant that is dried for conservation or the EO obtained from steam current distillation of the whole plant (not shredded) [11]. The cultivation and distillation processes of this plant represents a secular tradition.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antifungal Activity of Mentha x piperita (Lamiaceae) of Pancalieri (Turin, Italy) Essential Oil and Its Synergistic Interaction with Azoles

et al. 2019

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The promising antimicrobial activity of essential oils (EOs) has led researchers to use them in combination with antimicrobial drugs in order to reduce drug toxicity, side effects, and resistance to single agents. Mentha x piperita, known worldwide as “Mentha of Pancalieri”, is produced locally at Pancalieri (Turin, Italy). The EO from this Mentha species is considered as one of the best mint EOs in the world. In our research, we assessed the antifungal activity of “Mentha of Pancalieri” EO, either alone or in combination with azole drugs (fluconazole, itraconazole, ketoconazole) against a wide panel of yeast and dermatophyte clinical isolates. The EO was analyzed by GC-MS, and its antifungal properties were evaluated by minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) parameters, in accordance with the CLSI guidelines, with some modifications. The interaction of EO with azoles was evaluated through the chequerboard and isobologram methods. The results suggest that this EO exerts a fungicidal activity against yeasts and a fungistatic activity against dermatophytes. Interaction studies with azoles indicated mainly synergistic profiles between itraconazole and EO vs. Candida spp., Cryptococcus neoformans, and Trichophyton mentagrophytes. Thus, the “Mentha of Pancalieri” EO may act as a potential antifungal agent and could serve as a natural adjuvant for fungal infection treatment.

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Effect of Heat Stress on Yield, Monoterpene Content and Antibacterial Activity of Essential Oils of Mentha x piperita var. Mitcham and Mentha arvensis var. piperascens

Cited by 45 publications

References 26 publications

The Effects of Mentha × piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes

The Effects of Mentha × piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes

Alterations in photosynthetic pigments, antioxidant machinery, essential oil constituents and growth of menthol mint (Mentha arvensis L.) upon nickel exposure

Evaluation of the Antifungal Activity of Mentha x piperita (Lamiaceae) of Pancalieri (Turin, Italy) Essential Oil and Its Synergistic Interaction with Azoles

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