This paper presents linking computational research of the multilayer structure of the cladding of a three-layer panel made of highly porous polystyrene concrete developed using a new technology in comparison with traditional ones. The calculation of the thermal efficiency of the exterior fence was carried out in three stages, where the thermal regime was calculated from the values of temperature fields in the ELCUT 6.6 system, and the humidity and air modes were determined by the analytical method in the Maple system. The territory of central Kazakhstan (Karaganda) was selected as the research region, where the research showed that equating the thickness by the values of the actual and required heat transfer resistances of traditional multilayer structures to the developed one, the thickness of traditional structures increases from 3.09% to 27.83%. Moisture accumulation relative to the developed one occurs in all the studied structures. Thus, if in some cases of traditional structures moisture is collected by 2.61% and 9.48% less, in others moisture is collected by 27.94% and 119% more. However, the value of evaporated moisture during the drying period showed that all the moisture will evaporate during the specified period. Thus, all the structures meet the conditions for the inadmissibility of moisture for the annual period and the period of moisture accumulation. Moreover, the values of the actual and required permeabilities to air satisfy the condition, which affected the values of the temperature fields taking into account air filtration; the developed structure showed a positive effect for this value, and in traditional structures, the value of τint decreased to 1.35 °C depending on the option. The analytical results of the thermal inertia values of the developed and traditional multilayer structures showed that the developed structure exceeds traditional ones by up to 30.04% depending on the option, which is positive in the cold period. It was also found that the market prices of all traditional structures exceed the developed one by 1.2–2.5 times, depending on the design, which also emphasizes the positive aspects of the new design. Thus, the findings of this research will positively complement the catalog of products of external multilayer cladding structures made of effective materials and can be used by research communities and design organizations in the design of residential buildings.