Effect of Heavy Metals onAedes aegypti(Diptera:Culicidae) Larvae

Rayms-Keller, Alfredo; Olson, Ken E.; McGaw, M.; Oray, C.; Carlson, Jonathan O.; Beaty, Barry J.

doi:10.1006/eesa.1997.1605

Cited by 82 publications

(62 citation statements)

References 34 publications

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“…arrest in the sea urchin, oyster, crab, sea squirt, and in insects (2,9,40,56,57,71). Clustering and GO analyses showed that at high concentrations, copper upregulated genes associated with cell fate determination and differentiation, embryonic development, and cell polarity, including IFN-related developmental regulator 1 (IFRD1), myeloid cell leukemia sequence 1 (MCL1), jagged 1 (JAG1), delta-like 1 (DLL1), tissue inhibitor of metalloproteinase 1 (TIMP1), MAFB, adenylate cyclase-associated protein 1 (CAP1), FYVE, RhoGEF, PH domain-containing 6 (FGD6), and IL-11 (Tables 4 and 5 and Supplemental Material, Additional Data File 5).…”

Section: Continuedmentioning

confidence: 99%

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Song

Freedman

2009

Physiological Genomics

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Copper is an essential trace element; however, at supraphysiological levels, it can be extremely toxic. Microarray data from HepG2 cells exposed to 100, 200, 400, and 600 μM copper for 4, 8, 12 and 24 h were generated and analyzed. Principal components, K-means, and hierarchical clustering, interactome, and pathway mapping analyses indicated that these exposure conditions induce physiological and toxicological changes in the HepG2 transcriptome. As a general trend, when the level of toxicity increases, the number and diversity of affected genes, Gene Ontology categories, regulatory pathways, and complexity of interactomes increase. Physiological responses to copper include transition metal ion binding and responses to stress/stimulus, whereas toxicological responses include apoptosis, morphogenesis, and negative regulation of biomolecule metabolism. The global gene expression profile was overlaid onto biomolecular interaction networks and signal transduction cascades using pathway mapping and interactome identification. This analysis indicated that copper modulates signal transduction pathways associated with MAPK, NF-κB, death receptor, IGF-I, hypoxia, IL-10, IL-2, IL-6, EGF, Toll-like receptor, protein ubiquitination, xenobiotic metabolism, leukocyte extravasation, complement and coagulation, and sonic hedgehog signaling. These results provide insights into the global and molecular mechanisms regulating the physiological and toxicological responses to metal exposure.

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Section: Continuedmentioning

confidence: 99%

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Song

Freedman

2009

Physiological Genomics

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“…The pollution of aquatic ecosystems by trace metals is a significant problem (Rayms-Keller, et al, 1998), as trace metals constitute some of the most hazardous substances that can bio-accumulate (Tarifeno-Silva, et al, 1982). Bioaccumulation is the process in which a chemical pollutant enters the body of an organism and is not excreted but rather collected in the organism' s tissues (Zweig, et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Correlations, partitioning and bioaccumulation of trace metals between different segments of Taylor Creek, southern Nigeria

Okafor

Opuene

2006

Int. J. Environ. Sci. Technol.

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ABSTRACT:Correlations between trace metals in dissolved and particulate phases, B. bayad and sediments were investigated in five selected sites along Taylor Creek, which lies between longitude 006°17I to 006°21 I E and latitude 05°01 I to 05°05 I N. The degree of correlation between the various metals was different in each of the investigated segments. Between segments, not many significant correlations were recognized. Only Ni and Cd, Mn and Cd, Mn and Ni, and Mn and Pb are correlated in the sediments and in the particulate phase, Fe and Cr, Pb and Cd, and Zn and Ni are correlated, which suggests that the sources are not common for both compartments. Partitioning coefficients (K d ) of trace metals between dissolved and particulate phases are generally low, which is typical for fresh water ecosystems and fairly stable over Taylor Creek all through the seasons. Furthermore, the bio-concentration factors (BCF) of B. bayad were low unlike those of other natural waters. Cluster analysis showed that metal accumulation in the particulate phase differed from those observed in sediments, which also confirms that the pollution of the Creek might be from different sources.

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“…Metal-amino acids were synthesized using methods available in the literature (Rayms-Keller et al 1998, Baran et al 2000, Brumano 2008. The studies for the two acidic α-amino acids present in almost al1proteins, i.e., L-aspartic and L-glutamic acid.…”

Section: Synthesis Of Complexes L-glutamate-cu (Ii) and L-aspartate-cmentioning

confidence: 99%

Copper II - polar amino acid complexes: toxicity to bacteria and larvae of Aedes aegypti

Rodrigues

Arruda

Fernandes

et al. 2017

An. Acad. Bras. Ciênc.

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Control strategies using insecticides are sometimes ineffective due to the resistance of the insect vectors.In this scenario new products must be proposed for the control of insect vectors.The complexes L-aspartate Cu (II) and L-glutamate-Cu (II) complexes were synthesized and characterized by elemental analysis, visible ultraviolet, infrared spectroscopy and potentiometric titration. The toxicity of these complexes was analyzed in Aedes aegypti (Diptera: Culicidae) larvae and Gram-negative and Gram-positive bacteria. The interaction between the ligands and the amino acid balance and the distribution of the species as a function of pH were discussed. The lethal concentration median (LC 50 ) for Ae. aegypti larvae were: L-glutamic acidCu (

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Effect of Heavy Metals onAedes aegypti(Diptera:Culicidae) Larvae

Cited by 82 publications

References 34 publications

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Correlations, partitioning and bioaccumulation of trace metals between different segments of Taylor Creek, southern Nigeria

Copper II - polar amino acid complexes: toxicity to bacteria and larvae of Aedes aegypti

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