Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid.

Banerjee, Subhas; Hawksby, C.; Miller, Susan M.; Dahill, Stephen; Beattie, A. D.; McColl, Kenneth E.L.

doi:10.1136/gut.35.3.317

Cited by 161 publications

(123 citation statements)

References 27 publications

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“…It has been clarified that H. pylori induces inflammation in the gastric mucosa, not only by clinical studies showing that the concentration of vitamin C in the gastric juice of the H. pyloriinfected patient was low (20) and the amount of 8-oxodG, a biomarker of oxidative stress, of the gastric mucosa of the H. pylori infected patient was high (21), but also by animal data showing that H. pylori induced IL-8 production by gastric mucosal epithelial cells (22). Antioxidative substances have been expected to suppress inflammation, because the reactive oxygen species is related to the improvement of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Effect of black tea aqueous non-dialysate onHelicobacter pylori infection in Mongolian gerbils

Takabayashi¹,

Nakamura²,

Harada³

2004

Environ Health Prev Med

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Objectives: Recently, the appearance of Helicobacter pylori (H. pylori) resistant to antibiotics has been reported. The development of an antibiotic therapy which would not induce resistant strains of H. pylori is anticipated. In the present study, the antibiotic effect of black tea aqueous non-dialysate (BTND), the fraction different from tea catechins, on H. pylori was investigated using Mongolian gerbils infected with H. pylori.Methods: BTND was extracted from black tea leaves. A 0.1 w/v% solution of BTND or green tea catechins (GTC) was provided as drinking water to male NGS/Sea Mongolian gerbils infected with H. pylori (ATCC43504) for two weeks. Their stomachs were then excised, the mucosal surfaces were macroscopically observed, and colony forming units (CFU) of H. pylori were counted. The data were compared between the BTND and GTC groups.Results: The CFU of H. pylori were significantly decreased by intake of BTND. The body weight of the animals tended to be larger in the group supplied with BTND than in that supplied with GTC. Gastric mucosal injury tended to be smaller in the animals supplied with BTND than in those with GTC.Conclusions: These results suggest that BTND may have an inhibitory effect on H. pylori infection.

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Section: Discussionmentioning

confidence: 99%

Effect of black tea aqueous non-dialysate onHelicobacter pylori infection in Mongolian gerbils

Takabayashi¹,

Nakamura²,

Harada³

2004

Environ Health Prev Med

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“…Low intake of other nutrients such as ®ber, ascorbic acid and alcohol in patients with endoscopically veri®ed ulcer compared to controls has been reported by previous studies and similar to our results (Mullan et al, 1994). The possible protection of ascorbic acid in gastric juice against peptic ulceration and gastric carcinoma has been investigated (Banerjee et al, 1994). Studies have suggested that vitamin C protects against H. pylori infection (Nilius et al, 1991;Goodman et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Fermented milk products are associated to ulcer disease. Results from a cross-sectional population study

Elmståhl¹,

Svensson²,

Berglund³

1998

Eur J Clin Nutr

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Background: Prevalence of peptic ulcer disease has been associated to diet. Some dietary factors seem to have bactericidal effect which may modify the risk of peptic ulcer disease. The objective was to analyze associations between dietary habits and peptic ulcers. Design: A cross sectional population study. Subjects: One thousand, one hundred and thirty-®ve subjects out of 11 700 randomly invited men and women, aged 46±67 y, participating in a diet and disease study during 1991±1993. The study population comprised of 764 cases with reported peptic ulcer, 142 with dyspeptic symptoms and 229 randomly selected controls. Methods: X-ray examinations and endoscopies were reviewed and 332 out of 764 peptic ulcer cases were veri®ed. Mean daily intake of foods and nutrients were assessed with a combined 7 d menu book and a quantitative food frequency questionnaire, including dietary supplements. Results: Subjects with veri®ed ulcer had lower intake of fermented milk products and vegetables and higher intake of milk, meat and bread than controls. Intake of total fat, saturated and monounsaturated fatty acids and linolenic acid were higher in the ulcer group. Higher intake of fermented milk products, by quintiles showed a decreased ulcer risk; odds ratio 0.82 (0.71±0.95), adjusted for covariates below. Higher intake of milk, by quintiles, was associated with an increased risk of ulcer; odds ratio 1.17 (1.03±1.32). Smoking, foreign ethnicity and being unmarried or divorced were covariates associated to ulcer. Conclusion: This study indicates the multifactorial etiology of peptic ulcer including dietary factors. High intake of fermented milk products was associated with decreased risk for ulcer, whereas increased risk was noted for high milk intake. Sponsorship: The study was supported by the Swedish Cancer Society.

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“…Chronic gastritis is associated with excessive production of reactive oxygen metabolites and H. pylori infection is also associated with decreased intragastric ascorbic acid levels, a critical antioxidant. 20 H. pylori causes increased mucosal proliferation. 21,22 Increased cell proliferation is associated with an increased risk of somatic mutations due to replication errors and inadequate DNA repair.…”

Section: Pathogenesis Of Gastric Cancermentioning

confidence: 99%

Test and treat or test and scope for Helicobacter pylori infection. Any change in gastric cancer prevention?

Loughlin

Sebastian

O'Connor

et al. 2003

Aliment Pharmacol Ther

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SUMMARYA 'test and treat' strategy is advocated for patients with dyspepsia under the age of 45 years, with endoscopy reserved for those with alarm symptoms or aged over 45 years. One of the consequences of this strategy will be a reduction in population infection rates of Helicobacter pylori. It is now clear that H. pylori is one of the prime initiators of gastric cancer with up to 70% of gastric cancers attributable to H. pylori. What remains unclear is if H. pylori reduction will lead to a reduction in gastric cancer.

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Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid.

Cited by 161 publications

References 27 publications

Effect of black tea aqueous non-dialysate onHelicobacter pylori infection in Mongolian gerbils

Effect of black tea aqueous non-dialysate onHelicobacter pylori infection in Mongolian gerbils

Fermented milk products are associated to ulcer disease. Results from a cross-sectional population study

Test and treat or test and scope for Helicobacter pylori infection. Any change in gastric cancer prevention?

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