Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis

Sugano, Kentaro

doi:10.1007/s10120-018-0876-0

Cited by 144 publications

(138 citation statements)

References 55 publications

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“…Helicobacter pylori eradication can reduce the incidence of gastric cancer, especially in the early stages . Therefore, the implementation of the H pylori detection strategy for preventing H pylori ‐related diseases should be recommended.…”

Section: Discussionmentioning

confidence: 99%

Management of Helicobacter pylori infection by clinicians: A nationwide survey in a developing country

et al. 2019

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Background & Aims Developing countries are making efforts to improve health management. Practice deviating from the guideline means inefficient control. The study aims to investigate the management of Helicobacter pylori (H pylori) infection from a developing country perspective. Methods An authoritative survey was conducted in 14th (2014) and 17th (2017) Congress of Gastroenterology China, respectively. The Maastricht V/Florence consensus report was invoked as the evaluation criterion. Results A total of 4182 valid samples were included in this study. Most of the respondents (94%) updated knowledge by lectures. Respondents had a different awareness rate of H pylori‐related diseases, ranging from 45% to 95%. Up to 40% of the respondents did not follow the recommendations for the diagnosis. Choice accuracy of eradication regimens and antibiotic combinations was <70%. About 20% of the respondents did not pay attention to the confirmation after the eradication. The situation had been improved in 2017 when compared with that in 2014 (all P < .05). Multivariate logistic regression analysis revealed that influencing factors including nongastroenterologists, bachelor degree and below, the primary professional title, hospital location, and a small proportion of H pylori infection in daily practice related to the deviation of consensus (all P < .05). Conclusions Although the management of H pylori infection has been improved in a developing country, there is still a gap between the real‐world practices and the consensus. Influencing factors should be taken into account in decision‐making, and the corresponding population should be strengthened with precision training during the promotion of the guideline.

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Section: Discussionmentioning

confidence: 99%

Management of Helicobacter pylori infection by clinicians: A nationwide survey in a developing country

et al. 2019

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“…pylori infection has been documented as the major initiator in gastric cancer carcinogenesis and that eradication of H . pylori could reduce its occurrence, we hypothesized that this bacterium should be highly prevalent in Indigenous peoples. Therefore, screening and treating H .…”

Section: Methodsmentioning

confidence: 99%

Planning mass eradication of Helicobacter pylori infection for indigenous Taiwanese peoples to reduce gastric cancer

Bair

Chuang

Lei

et al. 2019

J of Gastro and Hepatol

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Background and Aim The aim of this study is to identify gastric cancer burden in Indigenous Taiwanese peoples and conduct a project to evaluate how to reduce the disparities most effectively in Indigenous communities. Methods First, we quantified the health disparities in gastric cancer in Indigenous peoples using data from the cancer registries during the period of 2006–2014. Second, we identified parameters that might be associated with Helicobacter pylori infection or help identify a good eradication strategy. Results Gastric cancer incidence (24.4 vs 12.3 per 100 000 person‐years) and mortality rates (15.8 vs 6.8 per 100 000 person‐years) were higher in Indigenous than in non‐Indigenous, with 2.19‐fold (95% confidence interval [CI]: 2.06–2.33) and 2.47‐fold (2.28–2.67) increased risk, respectively. In Indigenous communities, H. pylori infection was more prevalent in Indigenous than in non‐Indigenous (59.4% vs 31.5%, P < 0.01). Regression analyses consistently showed that either the mountain or plain Indigenous had 1.89‐fold (95% CI: 1.34–2.66) and 1.73‐fold (95% CI: 1.24–2.41) increased risk for H. pylori infection, respectively, as compared with non‐Indigenous, adjusting for other baseline characteristics. The high infection rates were similarly seen in young, middle‐aged, and older adults. Program eradication rates using clarithromycin‐based triple therapy were suboptimal (73.7%, 95% CI: 70.0–77.4%); the habits of smoking (1.70‐fold, 95% CI: 1.01–2.39) and betel nut chewing (1.54‐fold, 95% CI: 0.93–2.16) were associated with the higher risk of treatment failure. Conclusion Gastric cancer burden is higher in Indigenous Taiwanese peoples than in their non‐Indigenous counterparts. Eliminating the prevalent risk factor of H. pylori infection is a top priority to reduce this health disparity.

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“…Among their patients with H. pylori infection, general practitioners need to disseminate the importance of its eradication (with beneficial effects for both the patients and their children). General practitioners' involvement should be modulated to suit the health policy and health care organization of the countries where they operate, and the beneficial effects of their contribution will be all the greater, the higher the prevalence of the infection in the target population …”

Section: Discussionmentioning

confidence: 99%

“…General practitioners' involvement should be modulated to suit the health policy and health care organization of the countries where they operate, and the beneficial effects of their contribution will be all the greater, the higher the prevalence of the infection in the target population. 70,71 Endoscopists and pathologists are responsible for assessing early and advanced precancerous diseases and designing patienttailored follow-up strategies. High-resolution digital endoscopy currently enables a detailed assessment of mucosal lesions that were invisible 15 years ago.…”

Section: Con Clus Ionsmentioning

confidence: 99%

Gastric cancer prevention targeted on risk assessment: Gastritis OLGA staging

et al. 2019

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Gastric cancer (GC) ranks among the most lethal epithelial malignancies, and its striking mortality rate prompts a global prevention strategy. Helicobacter pylori (H. pylori) gastritis is the main GC promoter, and the 2014 Global Kyoto conference recognized H. pylori gastritis as a (treatable) infectious disease. It is therefore plausible that any large‐scale intervention for H. pylori eradication would result in cleansing the world of the fifth cause of cancer‐related death. Atrophic gastritis is the cancerization field in which GCs (both intestinal and diffuse histotypes) mainly develop. Discontinuing the inflammatory cascade triggered by H. pylori is tantamount to preventing GC. For patients (still infected or eradicated) who have already developed gastric atrophy, the severity/topography of the atrophic changes correlates with their cancer risk. Gastritis OLGA (Operative Link for Gastritis Assessment) staging consistently ranks the atrophy‐associated cancer risk, providing a solid clinical/biological rationale for establishing patient‐specific surveillance programs. By combining primary and secondary prevention strategies, gastric cancer is a preventable disease.

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Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis

Cited by 144 publications

References 55 publications

Management of Helicobacter pylori infection by clinicians: A nationwide survey in a developing country

Management of Helicobacter pylori infection by clinicians: A nationwide survey in a developing country

Planning mass eradication of Helicobacter pylori infection for indigenous Taiwanese peoples to reduce gastric cancer

Gastric cancer prevention targeted on risk assessment: Gastritis OLGA staging

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