Effect of Helicobacter pylori infection on pregnancy rates and early pregnancy loss after intracytoplasmic sperm injection

Hajishafiha, M; Ghasemi-Rad, Mohammad; Memari, A.; Naji, Siamak; Mladkova, Nikol; Saeedi, Vida

doi:10.2147/ijwh.s24424

Cited by 14 publications

(8 citation statements)

References 30 publications

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“…Bahceci & Ulug (2004) found no significant association between cause of infertility and rate of early miscarriage. This is not consistent with the results described by Hajishafiha et al . (2011), in a study that found a significant relationship between the causes of infertility and the rate of miscarriage.…”

Section: Discussioncontrasting

confidence: 99%

Factors associated with spontaneous abortion following intracytoplasmic sperm injection (ICSI)

Basirat

Kashifard

Golsorkhtabaramiri

et al. 2019

JBRA Assisted Reproduction

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Objective: The aim of this study was to describe the miscarriage rates and the factors associated with cases of spontaneous abortion observed in women offered intracytoplasmic sperm injection (ICSI). Methods: This cross-sectional study enrolled women who became pregnant with the aid of ICSI treated at the Babol Infertility Center (Iran) within a period of five years (2010-2015). Data were collected from patient charts and, in some cases, through phone calls. The study looked into the incidence of spontaneous abortion in women offered ICSI and the factors associated with miscarriage. The chi-square test, Fisher's exact test, and the t-test were used to analyze the data. Results: From a total of 145 pregnant women, 120 were included in our study. The prevalence of miscarriage was 20%. Galactorrhea was significantly more present in patients who had miscarriages (25% vs. 9.37%, p =0.04). There was a marked difference in the duration of infertility of miscarriage and non-miscarriage patients offered ICSI (6.6±8.3 vs. 4.9±7.3 years, p =0.05). No association was found between maternal age, BMI, cause of infertility, hormonal pattern, type of infertility, history of surgery, polycystic ovary syndrome, number of oocytes, or day of retrieval with miscarriage.

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Section: Discussioncontrasting

confidence: 99%

Factors associated with spontaneous abortion following intracytoplasmic sperm injection (ICSI)

Basirat

Kashifard

Golsorkhtabaramiri

et al. 2019

JBRA Assisted Reproduction

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“…However, endogenous uterine AP may not be sufficient during chronic or an inordinate levels of LPS. Intrauterine and systemic infections have been linked to the incident of early pregnancy losses (EPLs) and preterm births (PTBs) from pregnancies achieved naturally or by assisted reproductive technologies [ 1 , 68 , 69 ]. Results from clinical studies using antibiotics to reduce the rate of EPL and PTB by killing bacteria were mixed and disappointing [ 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

Alkaline Phosphatase Protects Lipopolysaccharide-Induced Early Pregnancy Defects in Mice

Wei

Herington

et al. 2015

PLoS ONE

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Excessive cytokine inflammatory response due to chronic or superphysiological level of microbial infection during pregnancy leads to pregnancy complications such as early pregnancy defects/loss and preterm birth. Bacterial toxin lipopolysaccharide (LPS), long recognized as a potent proinflammatory mediator, has been identified as a risk factor for pregnancy complications. Alkaline phosphatase (AP) isozymes have been shown to detoxify LPS by dephosphorylation. In this study, we examined the role of alkaline phosphatase (AP) in mitigating LPS-induced early pregnancy complications in mice. We found that 1) the uterus prior to implantation and implantation sites following embryo implantation produce LPS recognition and dephosphorylation molecules TLR4 and tissue non-specific AP (TNAP) isozyme, respectively; 2) uterine TNAP isozyme dephosphorylates LPS at its sites of production; 3) while LPS administration following embryo implantation elicits proinflammatory cytokine mRNA levels at the embryo implantation sites (EISs) and causes early pregnancy loss, dephosphorylated LPS neither triggers proinflammatory cytokine mRNA levels at the EISs nor induces pregnancy complications; 4) AP isozyme supplementation to accelerate LPS detoxification attenuates LPS-induced pregnancy complications following embryo implantation. These findings suggest that a LPS dephosphorylation strategy using AP isozyme may have a unique therapeutic potential to mitigate LPS- or Gram-negative bacteria-induced pregnancy complications in at-risk women.

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“…An association between H. pylori and LBW has been suggested [ 13 , 14 ]. However, there is limited data on association between H. pylori and birth weight especially in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Effect of maternal Helicobacter Pylori infection on birth weight in an urban community in Uganda

Wanyama

Kagawa

Opio

et al. 2016

BMC Pregnancy Childbirth

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BackgroundHelicobacter pylori, a widespread infection particularly in developing countries has been associated with many adverse effects during pregnancy including hyperemesis gravidarum, neural tube defects in newborns, intrauterine fetal growth restriction and miscarriage. We sought to document the effects of H. pylori infection on birth weight in a low-income setting in Kampala, Uganda.MethodsThis was a prospective cohort study conducted in Kampala between May 2012 and May 2013. The participants were H. pylori positive and H. pylori negative HIV negative primigravidae and secundigravidae. Recruitment was at ≤18 gestation weeks and follow up assessments were carried out at 26 and 36 gestation weeks and soon after delivery. H. pylori infection was determined using H. pylori stool antigen test. Maternal weight and height were measured, and body mass index (BMI) and gestational weight gain were calculated. Only term and live babies were considered. Low birth weight (LBW) was defined as a birth weight of <2500 gram.ResultsA total of 221 participants were enrolled with mean ± standard deviation (SD) age of 20.9 ± 2.7 years. The mean ± SD gestation age at delivery was 39.4 ± 1.0 weeks. Primigravidae were 61.5 % (n = 188) and 52.9 % (n = 117) of the participants were positive for H. pylori infection. Low pre-pregnancy BMI (<18.5 kg/m2) was recorded in 14.6 % (n = 28) while 38 % (n = 73) had a height <156 cm at recruitment. Of the infants born to the participants, 13.6 % (n = 26) had low birth weight (<2500 gram).Independent predictors for LBW were the mother being positive for H. pylori infection (odds ratio, OR, 3.6, 95 % CI 1.1 – 11.5; P = 0.031) maternal height at recruitment <156 cm (OR 3.4, 95 % CI 1.4–8.2; P = 0.008) and maternal weight gain rates <0.3 kg/week during the 2nd and 3rd trimesters (OR 3.8, 95 % CI 1.0–14.1; P = 0.044).ConclusionH. pylori infection is associated with LBW among primigravidae and secundigravidae in Kampala, Uganda.

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Effect of Helicobacter pylori infection on pregnancy rates and early pregnancy loss after intracytoplasmic sperm injection

Cited by 14 publications

References 30 publications

Factors associated with spontaneous abortion following intracytoplasmic sperm injection (ICSI)

Factors associated with spontaneous abortion following intracytoplasmic sperm injection (ICSI)

Alkaline Phosphatase Protects Lipopolysaccharide-Induced Early Pregnancy Defects in Mice

Effect of maternal Helicobacter Pylori infection on birth weight in an urban community in Uganda

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