Effect of hematocrit on pharmacokinetics of tacrolimus in adult living donor liver transplant recipients

Erythroid Recovery Affects Tacrolimus Levels after Engraftment during Stem Cell Transplantation

“…16) As the present patients with anemia were managed by blood transfusions to maintain their level of Hct at >20%, it may be necessary to take Hct fluctuations into consideration when assessing C/D ratios. 17) Hct levels were stable at 26.7± 6.6% and 25.7± 4.0% during pre-to post-engraftment, respectively, and we had a good correlation between concentrations and clinical conditions. In addition, concentrations were assessed as C/D ratios and were compared between pre-and post-stages as variation ratios.…”

The minimal impact of food on the pharmacokinetics of ridaforolimus

“…As is the case with other rapamycin analogs, ridaforolimus exhibits saturable binding to erythrocytes and subsequently a relatively high blood to plasma ratio [10][11][12]. This characteristic inXuences selection of matrix for evaluation (i.e., plasma versus blood).…”

The effect of multiple doses of rifampin and ketoconazole on the single-dose pharmacokinetics of ridaforolimus

“…Although the DFC formulation differs from the formulation proposed for marketing (i.e., ECT), the DFC formulation was administered both when ridaforolimus was given alone and in combination with ketoconazole to avoid a potential confounding effect of formulation. As with other rapamycin analogs, ridaforolimus exhibits saturable binding to erythrocytes that results in a relatively high blood to plasma ratio [3,14,15]. Given the relatively low ridaforolimus levels in plasma, the pharmacokinetic results in this evaluation are based on wholeblood, not plasma, exposures.…”