Effect of hemodialysis on visual acuity, intraocular pressure, and macular thickness in patients with chronic kidney disease

Chelala, Elias; Dirani, Ali; Fadlallah, Ali; Slim, Élise; Abdelmassih, Youssef; Fakhoury, Henry; Baz, Patrick; Bejjani, R.A.

doi:10.2147/opth.s74481

Cited by 26 publications

(49 citation statements)

References 23 publications

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“…Ocular manifestations of hemodialysis include reduction of intraocular pressure and choroidal thickness. 3 , 4 Because the fluid in the subretinal space is actively transported by the retinal pigment epithelium toward the choroid, this continuity supports the possibility of hemodialysis-associated shifts in choroidal fluid dynamics affecting subretinal fluid clearance.…”

Section: Discussionmentioning

confidence: 80%

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2015

RETINAL Cases &Amp; Brief Reports

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Section: Discussionmentioning

confidence: 80%

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“…Ocular abnormalities are frequently associated with patients on chronic dialysis, including IOP fluctuation, corneal calcification, retinal hemorrhage, retinal toxicity related to desferrioxamine, anterior ischemic neuropathy, and uremic optic neuropathy [ 24 ]. Among them, the relationship between IOP changes and dialysis has been reported with various results [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 25 ]. Moreover, there has long been a debate regarding whether transient IOP changes during HD would result in the progression of glaucoma [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have discussed intraocular pressure (IOP) changes during HD since the first demonstration of an increase in IOP during dialysis in 1964 [ 5 , 6 ]. Some studies have revealed that IOP may be elevated [ 6 , 7 , 8 , 9 , 10 ], some have shown that IOP does not change [ 11 , 12 ], and some have demonstrated that IOP decreases [ 13 , 14 , 15 , 16 , 17 ]. However, these previous results were either limited by small patient numbers, a short follow-up period, or lack of a comparative group.…”

Section: Introductionmentioning

confidence: 99%

Risk of Glaucoma in Patients Receiving Hemodialysis and Peritoneal Dialysis: A Nationwide Population-Based Cohort Study

Lim

Lee

Huang

et al. 2020

IJERPH

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This paper investigated the incidence and risk of newly diagnosed glaucoma after the initiation of maintenance dialysis in Taiwan. A case–control study was conducted using the National Health Insurance Research Database (NHIRD) in Taiwan. There were 3949 patients with dialysis in the study group and 78,980 non-dialysis subjects matched by age and sex in the comparison group. The incidence of newly diagnosed glaucoma after the initiation of maintenance dialysis was analyzed based on the diagnostic code for glaucoma. Patients with dialysis had a higher risk of glaucoma (adjusted hazard ratio (aHR): 1.270; 95% confidence interval (CI): 1.035–1.560) than patients without dialysis. The incidence rate of glaucoma was 8.18 per 10,000 person months in the dialysis group, which was higher than that in the non-dialysis group (5.01 per 10,000 person months). Patients with dialysis exhibited a significantly higher risk of angle-closure glaucoma (ACG) (aHR: 1.550; 95% CI: 1.074–2.239). In contrast, there was no significant risk of developing open-angle glaucoma or normal-tension glaucoma in dialysis patients. Our data suggest that dialysis patients are more susceptible to ACG. Regular ophthalmic examinations may be useful in patients with dialysis to identify high-risk individuals with glaucoma, and preventive measures can be applied to avoid permanent vision loss as soon as intraocular pressure (IOP) elevation is identified.

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“…Visual acuity depends on the health of the cornea, lens, and retina, all of which are prone to change during HD [11].…”

Section: Discussionmentioning

confidence: 99%

Ocular Changes in Egyptian Children on Regular Hemodialysis

El-Ghany¹,

El-Salam²,

Farag³

et al. 2019

IJCM

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Background: Chronic Kidney disease (CKD) may cause ocular disorders for many reasons such as uraemia, haemodialysis and hypertension. Aim: To study the ocular changes in a group of Egyptian children with chronic kidney disease on regular hemodialysis. Subjects and Methods: This cross-sectional comparative study was conducted on 30 children on regular hemodialysis and another 30 age and sex-matched healthy children as controls. Their ages ranged from 4 to 17 years. Complete ophthalmological examination including; visual acuity and refraction, anterior segment examination, intraocular pressure (IOP), fundus examination and colored photography were assessed in the same line with routine laboratory investigations for children on regular hemodialysis and their controls. The relation of ocular disorders with related clinical and biochemical variables was measured statistically. Results: The most common eye abnormalities recorded were decreased visual acuity in Lt eye (73.3%) and Rt eye (60%), followed by corneal & conjunctiva calcification were (16.7%) and (13.3%) respectively and fundal changes (13.3%) of the study population. A significant positive relation was found between fundal changes particularly tortuous blood vessel abnormalities with the duration of hemodialysis and serum creatinine level. Conclusion: Ocular abnormalities are common than expected in children on regular hemodialysis. Visual acuity disorder is the major ocular abnormalities recorded in those patients. Regular ophthalmologic assessment is recommended in children to prevent longer-term visual complications.

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Effect of hemodialysis on visual acuity, intraocular pressure, and macular thickness in patients with chronic kidney disease

Cited by 26 publications

References 23 publications

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Risk of Glaucoma in Patients Receiving Hemodialysis and Peritoneal Dialysis: A Nationwide Population-Based Cohort Study

Ocular Changes in Egyptian Children on Regular Hemodialysis

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