Effect of heparin in effort angina

Allopurinol in psoriasis–a double-blind study

“…Had there been more 'placebo reactors' (Lasagna et al, 1954) in the control group than in the group receiving allopurinol, we would not have expected a complete lack of response in four of the seven patients initially on the placebo. Moreover, even if there were no distinct rebound phenomena, some worsening of the condition might have been expected in the two patients who had received allopurinol first and improved, barring a very protracted 'carry-over' effect (Rinzler et al, 1953). We are thus inclined to believe that the absence of a rebound phenomenon, as stressed by Viglioglia et al (1970), is a feature of the natural course of psoriasis, as in our case 6, who commenced to clear rapidly on the placebo, and in whom new lesions appeared at the end of the allopurinol period.…”

An Evaluation of Long-Term Anticoagulant Therapy

“…In recent years the use of heparin has been advocated for the prevention of recurrent infarction and for the relief of angina pectoris. The favourable effect on angina when administered intermittently twice weekly, as observed by Graham et al (I95I) and Engelberg (1952), could not be confirmed by several workers (Russek et al, 1952;Miller et al, 1952;Binder et al, 1953;Gruner et al, 1953;Rinzler et al, I953; Chandler and Mann, 1953). However, Engelberg et al (i955) administered 200 mg. of heparin by the subcutaneous route twice weekly to o05 survivors of myocardial infarction for a total period of 2,067 patient-months with only four deaths, whereas of 118 control patients receiving placebo treatment, 2z died during a similar period of observation.…”

Clinical Pharmacology

“…This important paper probably owed something to Dixon's influence, since one of the authors was a close colleague of his. This technique with some improvements has been used by others in more recent years to study the effect of other drugs such as vitamin E (Travell et al, 1949), khellin (Greiner et al, 1950 and heparin (Rinzler et al, 1953). All these authors agree that the effects of the drugs tested for the continuous treatment of angina pectoris were practically the same as the effects of dummy treatments.…”