Effect of Heparin on the Vasoconstrictor Action of Shed Blood Tested by Perfusion of the Rabbit's Ear

Sympathectomy for Occlusive Arterial Disease††

“…This was shown by Landis et al . (1) in the severed ears of a rabbit and repeated by Levinson and Essex (2) and Page (3). Page produced spasm in the vessels of a rabbit ear by injecting the substance contained in the blood of a shocked dog's ear.…”

Kidney Enzymes and Essential Hypertension

“…At least four proteolytic enzymes, known as kidney cathepsins I, 11,111, and IV, were found in crude kidney extracts. In their substrate specificity these intracellular proteinases show similarities to pepsin, trypsin, aminopeptidase, and carboxypeptidase, respectively (1 1).…”

The Lymphatic System

“…Alrich (3 4) extended this work to an examination of lymph from the burned feet of dogs in relation to the possible presence of vasoconstrictor and vasodilator substances. He collected lymph from the normal and burned feet of anesthetized dogs and found, using the method of Landis, Wood & Guerrant (35) ' in which the ear of a rabbit is perfused and reduction or increase in outflow of the perfusate from the veins is used to indicate constriction or dilatation of the vessels in the part, that when he added lymph from a burned part \ to the perfusate, vasoconstriction occurred. This was not one of the vasoconstrictor substances characteristic:; of serum and asso ciated with coagulation, since it was found in lymph from burned animals previously heparinized so that no coagulation could take place.…”