Effect of hepatic artery embolization on the adenylate energy charge level and the redox state of the cirrhotic liver

Taki, Yoshiro; Jikko, Akira; Morimoto, Tetsuya; Yokoo, Naoki; Tanaka, Junji; Tani, Tomohiko; Kamiyama, Yasuo; Tobe, Takayoshi; Ozawa, Kazue

doi:10.1007/bf01852043

Res. Exp. Med.

1986

DOI: 10.1007/bf01852043

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Effect of hepatic artery embolization on the adenylate energy charge level and the redox state of the cirrhotic liver

Yoshiro Taki

Akira Jikko

Tetsuya Morimoto

et al.

Abstract: Hepatic energy charge ((ATP + 1/2ADP)/(ATP + ADP + AMP)) and arterial blood ketone body ratio (acetoacetate/3-hydroxybutyrate) were measured after hepatic artery embolization in carbon-tetrachloride-induced cirrhotic rats. In normal livers, energy charge slightly decreased at 3 h and returned to normal levels at 6 h. By contrast, in cirrhotic livers, energy charge was drastically decreased at 3 h after embolization and was not completely recovered at 6 h. Blood ketone body ratio, reflecting hepatic mitochondri… Show more

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Cited by 5 publications

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The Relevance of the Order of Revascularization in Liver Grafting

Hickman¹,

Innes²

1990

Hepatology

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A study was conducted comparing the effects of initial arterialization vs. initial portal revascularization in unstored warm ischemic (for 30 min) livers, livers stored for 4 hr at 0 degrees C in Collins solution and livers rendered warm ischemic for 1 hr before removal and replacement as autografts. All livers that received initial arterialization showed uniform diffuse perfusion, whereas those with initial portal perfusion were patchy and well perfused only in the right lobe. In the experimental animal, initial arterialization using an end-to-end method was much easier and required less retraction. The energy charge and ATP levels dropped sharply during brief warm ischemia but returned rapidly to normal on revascularization. Although the decline in energy charge was less in stored livers, the return to normal was slower and incomplete. Plasma levels of AST indicated much greater damage in the stored livers and were lowest in recipients in unstored livers that were arterialized first. After longer warm ischemia, energy charge values declined and only completely returned to 60% of preoperative values within 2 hr of grafting. Despite this, the survival rate of these animals was very poor and only one survived overnight. Seven of the 12 survived the procedure, but in five death occurred within 30 min of full revascularization. In this group, AST levels rose sharply after revascularization to a mean level of 1,000 U.(ABSTRACT TRUNCATED AT 250 WORDS)

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The Relevance of the Order of Revascularization in Liver Grafting

Hickman¹,

Innes²

1990

Hepatology

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Energy metabolism changes and oxidative attack after hepatic arterial embolization and chemoembolization in thioacetamide-induced cirrhotic livers

et al. 1991

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Hepatic energy metabolism and oxidative attack were studied after transcatheter arterial embolization (TAE) and chemoembolization (TAC) of the left and median lobes of the liver using thioacetamide (TAA)-induced cirrhotic rats. TAE was carried out using gelatin sponge (1.5 mg/cm3) dissolved in saline solution (SS). TAC was performed by adding mitomycin C (MMC) (1.6 mg/kg body weight) to the previous embolic solution. The energy charge (EC) of embolized lobes decreased from 0.86 to 0.78 and 0.74 1 h after TAE and TAC, respectively, but was restored 3 h later. Adenosine 5'-triphosphate (ATP) and total adenine nucleotide content (TAN) of embolized and non-embolized lobes was also temporarily decreased. Total hepatic blood flow (THBF) of embolized and chemoembolized lobes was reduced in almost 50%, and it took 1 week to become normalized. After TAC (3 and 6 h, respectively), total glutathione (TGSH) content was reduced from 7.02 mumol/g of liver to around 4.5 mumol/g, and malondialdehyde (MDA) content increased from 196.94 nmol/g of liver to values above 300 nmol/g. TAE in cirrhotic livers did not induce any changes in these parameters. In conclusion, after TAE and TAC the hepatic energy metabolism is temporarily altered by ischemia. TAC-induced oxidative attack, in addition to ischemia and MMC, could be one of the mechanisms explaining the effectiveness of this therapy.

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The effect of hepatic devascularisation in the pig upon the energy charge and ketone ratio

Hickman

Oakland

Innes

et al. 1988

Journal of Hepatology

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Effect of hepatic artery embolization on the adenylate energy charge level and the redox state of the cirrhotic liver

Cited by 5 publications

References 12 publications

The Relevance of the Order of Revascularization in Liver Grafting

The Relevance of the Order of Revascularization in Liver Grafting

Energy metabolism changes and oxidative attack after hepatic arterial embolization and chemoembolization in thioacetamide-induced cirrhotic livers

The effect of hepatic devascularisation in the pig upon the energy charge and ketone ratio

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