Effect of hexavalent carcinogenic chromium on carp Cyprinus carpio immune cells

Steinhagen, Dieter; Helmus, T; Maurer, S.; Rd, Michael; Leibold, W.; Scharsack, Jörn P.; Skouras, Andreas; Hj, Schuberth

doi:10.3354/dao062155

Cited by 41 publications

(22 citation statements)

References 32 publications

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“…Steinhagen et al [51] examined the effect of Cr on carp (Cyprinus carpio)-derived immune cells. The results demonstrated that at concentrations between 2 and 200 μmol L −1 Cr, the metal induced cytotoxicity and decreased the activation of mitogen-induced lymphocytes, as well as phagocyte functions.…”

Section: +mentioning

confidence: 99%

Sediment Heavy Metal Contaminants in Vasai Creek Of Mumbai: Pollution Impacts

Singare¹,

Trivedi²

2012

CHEMISTRY

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In the present investigation, quantification study of different toxic heavy metals in the sediment samples of Vasai Creek of Mumbai was performed using Atomic Absorption Spectroscopy technique. The study is of importance because such assessment of heavy metals in sediments helps to understand long term pollution load in aquatic environment. Such study will also help to provide a means for evaluating the long term accumulation of heavy metal contaminants. The results of the study indicates that the concentration level of most of the toxic heavy metals like Al, As, Cd, Cr, Hg, Ni, Pb, Sr and Mn for the assessment year 2010-11 were higher than that obtained for the year 2009-10 by the factor of 1.0 to 2.5 µg/g. It is expected that results of present investigation will help in rational planning of pollution control strategies so as to reduce the toxicity impact on marine life of Vasai Creek.

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Section: +mentioning

confidence: 99%

Sediment Heavy Metal Contaminants in Vasai Creek Of Mumbai: Pollution Impacts

Singare¹,

Trivedi²

2012

CHEMISTRY

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“…Besides the lungs and intestinal tract, the liver and kidney are often target organs for chromate toxicity [53]. In natural waters, exposure to Cr has demonstrated cumulative deleterious effects on fishes as a function of time [54,55]. In the present investigation it was observed that Cr concentration at L1, L2 and L3 sampling stations lies in the range of 92-932, 25-1656 and 63-1822 µg/g respectively.…”

Section: Resultsmentioning

confidence: 55%

Sediment Contamination Due to Toxic Heavy Metals in Mithi River of Mumbai

Singare¹,

Mishra²,

Trivedi³

2012

AAC

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The present study deals with quantification of accumulated toxic heavy metals in sediments of Mithi River of Mumbai. The study was performed at three different sampling locations along the flow of Mithi River for two years from 2009-12. The different heavy metals studied were Al, As, Cd, Cr, Hg, Ni, Pb, Sr and Mn. The results of our study indicate that the concentration level of these toxic heavy metals for the two assessment years increases by the factor of 1.2-5.8 µg/g. The result is a clear indication of day by day increasing pollution level of the Mithi River, which is creating negative environmental impact on biological life of the river. The results emphasises the need of regular scientific monitoring of different pollutants adversely affecting the environment and to reframe the pollution control strategies already in existence.

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“…4). Steinhagen et al (2004) reported a similar suppression of NO secretion during in vitro exposure of head kidney leucocytes of carp Cyprinus carpio to 20 µmol l -1 Cr (VI) over 96 h. Tian & Lawrence (1996) reported that chromium suppressed the activity of an NO-producing enzyme (inducible NO synthase) in murine macrophages. Our study revealed negative modulation of RNI production in response to elevated levels of Cr (VI).…”

Section: Discussionmentioning

confidence: 75%

Immune response and disease resistance of Oreochromis mossambicus to Aeromonas hydrophila after exposure to hexavalent chromium

Prabakaran¹,

Binuramesh²,

Steinhagen³

et al. 2006

Dis. Aquat. Org.

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The objective of this study was to investigate the effect of chronic exposure to sublethal concentrations of hexavalent chromium (K 2 Cr 2 O 7 ) on the immune response and disease resistance of Oreochromis mossambicus (Peters) to bacterial Aeromonas hydrophila infection. Fish (45 to 50 g) were exposed to 0.005, 0.05, 0.5, and 5 mg l -1 [0.01, 0.1, 1, and 10% LC 50 , respectively] of hexavalent chromium Cr (VI) for 28 d. The specific immune response was assessed by antibody response to A. hydrophila by bacterial agglutination assay, and to sheep red blood cells (SRBC) by plaque forming cell (PFC) assay. In addition, nonspecific immune mechanisms were assessed by serum lysozyme activity and reactive nitrogen intermediates, the latter in terms of nitric oxide (NO) production by peripheral blood leucocytes. Overall immunity was assessed by disease resistance against live virulent A. hydrophila. The study clearly indicated that chronic exposure of fish to 0.5 and 5 mg l -1 of chromium (VI) decreased both nonspecific and specific parameters of the immune system, which resulted in a lower disease resistance to A. hydrophila. Interestingly, 0.05 mg l -1 of Cr (VI) enhanced disease resistance and both nonspecific and specific immune responses to A. hydrophila. Our study revealed a concentration-dependent modulation of the immune system by chromium (VI), as demonstrated by suppressive or stimulatory effects on lymphocytes, lysozyme, phagocytic killing mechanisms, and disease resistance in O. mossambicus.

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Effect of hexavalent carcinogenic chromium on carp Cyprinus carpio immune cells

Cited by 41 publications

References 32 publications

Sediment Heavy Metal Contaminants in Vasai Creek Of Mumbai: Pollution Impacts

Sediment Heavy Metal Contaminants in Vasai Creek Of Mumbai: Pollution Impacts

Sediment Contamination Due to Toxic Heavy Metals in Mithi River of Mumbai

Immune response and disease resistance of Oreochromis mossambicus to Aeromonas hydrophila after exposure to hexavalent chromium

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