Effect of HGV-infection on clinical course of hepatitis C and the possible role of endogenous interferon

Abstract

Light form of disease flow was observed in 69.3% (9/13) among the patients with acute hepatitis C, and in 77.8% (7/9) among the patients with non verified hepatitis. Detectability of RNA-HGV consists of 77.8% (7/9) and 42.8% (3/7) correspondingly among the patients' groups with light form of disease. All HGV RNA positive patients had 2 times lower content of total bilirubin and ALT in the blood comparing to RNA-HGV negative patients. HGV showed an active (4.7 EA) ability to induce the interferon formation. The C + G hepatitis patients had interferon titer equal to 3.7 EA, which apparently provides relief of hepatitis C clinical picture.