Effect of Hibiscus sabdariffaon blood pressure and electrolyte profile of mild to moderate hypertensive Nigerians: A comparative study with hydrochlorothiazide

Abstract

HS was a more effective antihypertensive agent than HCTZ in mild to moderate hypertensive Nigerians and did not cause electrolyte imbalance. HS showed longer duration of action compared to HCTZ and reduction in serum Na+ may be another antihypertensive mechanism of action of HS.

The efficacy of sour tea (Hibiscus sabdariffa L.) on selected cardiovascular disease risk factors: A systematic review and meta‐analysis of randomized clinical trials

“…The characteristics of included studies are outlined in Table . In summary, seven trials (Asgary et al, ; Chang et al, ; Gurrola‐Díaz et al, ; Kafeshani et al, ; Kuriyan, Kumar, Rajendran, & Kurpad, ; McKay et al, ; Nwachukwu et al, ) consisting of 362 unique participants with mean age of 44 years old were included in the pooling analysis. Studies were conducted in Iran (Asgary et al, ; Kafeshani et al, ), Taiwan (Chang et al, ), India (Kuriyan et al, ), the United States (McKay et al, ), Nigeria (Nwachukwu, Aneke, Nwachukwu, et al, ), and Mexico (Gurrola‐Díaz et al, ).…”

“…Except Kafeshani et al (), all studies enrolled both gender. Participants' health conditions were different among studies: Two studies recruited patients with hypertension (McKay et al, ; Nwachukwu, Aneke, Nwachukwu, et al, ), one study included patients with metabolic syndrome (Asgary et al, ), two studies enrolled healthy adults (Kafeshani et al, ; Kuriyan et al, ), one trial included obese adult with fatty liver (Chang et al, ), and one study involved both healthy and metabolic syndrome patients (two separate participant groups (Gurrola‐Díaz et al, ). Dose of supplementation and duration of follow‐up varied between studies.…”

“…Although all studies were randomized, the information around methodology of randomization and allocation concealment were provided for only five studies (Asgary et al, ; Gurrola‐Díaz et al, ; Kafeshani et al, ; McKay et al, ; Nwachukwu, Aneke, Nwachukwu, et al, ). Five studies had blinded designs (Asgary et al, ; Chang et al, ;Kafeshani et al, ; Kuriyan et al, ; McKay et al, ), and attrition and reporting biases were well addressed in all trials.…”

“…This study included only studies that investigated sour tea effect by comparing with inactive control intervention. However, the question remains, “Is the blood pressure lowering effect of sour tea comparable to conventional anti‐hypertensive pharmacological agents?” A casual analysis was run on six studies (A Herrera‐Arellano et al, ; Armando Herrera‐Arellano et al, ; Nwachukwu, Aneke, Nwachukwu, et al, ; Nwachukwu, Aneke, Obika, & Nwachukwu, ; Seck et al, ; Soleimani, Akbari, Soleimani, Mousavi, & Tamadon, ), which were not included in this review (because of nonsuitability of their control groups) to answer this question. The forest plot showed that, in general, the effect of sour tea on blood pressure is remarkably lower than antihypertensive drugs (Figure S1).…”

Plant-Derived Polyphenols in Human Health: Biological Activity, Metabolites and Putative Molecular Targets

“…The vast majority of clinical trials assayed with HS extracts show the antihypertensive effectiveness of this extract in patients with metabolic syndrome and hypertension. According to most studies, the antihypertensive effect of HS extract is related to the inhibition of angiotensin I-converting enzyme (ACE) and a reduction in serum sodium levels [41,42]. Nevertheless, Joven et al suggested that the inhibition of ACE activity contributes in a lesser degree and that the antioxidant, anti-inflammatory and endothelium-dependent effects are, most likely, the mechanisms involved in the hypotensive effect of HS [21].…”