Effect of high-dose dexamethasone on endothelial haemostatic gene expression and neutrophil adhesion

Kerachian, Mohammad Amin; Cournoyer, Denis; Harvey, Edward J.; Chow, Terry Y.-K.; Neagoe, Paul‐Eduard; Sirois, Martin G.; Séguin, Chantal

doi:10.1016/j.jsbmb.2009.05.001

Cited by 44 publications

(37 citation statements)

References 53 publications

(68 reference statements)

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“…2). Two in vitro studies showed that GCs may increase the release of VWF and mRNA expression of VWF from cultured human umbilical vein endothelial cells (68,69). A positive correlation was found between plasma cortisol and vWF levels, with a 1 mg/ml rise in plasma cortisol causing a 2.52 IU/dl increase in vWF (28).…”

Section: Platelet Activationmentioning

confidence: 98%

MECHANISMS IN ENDOCRINOLOGY: The spectrum of haemostatic abnormalities in glucocorticoid excess and defect

Isidori

Minnetti

Sbardella

et al. 2015

European Journal of Endocrinology

107

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Glucocorticoids (GCs) target several components of the integrated system that preserves vascular integrity and free blood flow. Cohort studies on Cushing's syndrome (CS) have revealed increased thromboembolism, but the pathogenesis remains unclear. Lessons from epidemiological data and post-treatment normalisation time suggest a bimodal action with a rapid and reversible effect on coagulation factors and an indirect sustained effect on the vessel wall. The redundancy of the steps that are potentially involved requires a systematic comparison of data from patients with endogenous or exogenous hypercortisolism in the context of either inflammatory or non-inflammatory disorders. A predominant alteration in the intrinsic pathway that includes a remarkable rise in factor VIII and von Willebrand factor (vWF) levels and a reduction in activated partial thromboplastin time appears in the majority of studies on endogenous CS. There may also be a rise in platelets, thromboxane B2, thrombin-antithrombin complexes and fibrinogen (FBG) levels and, above all, impaired fibrinolytic capacity. The increased activation of coagulation inhibitors seems to be compensatory in order to counteract disseminated coagulation, but there remains a net change towards an increased risk of venous thromboembolism (VTE). Conversely, GC administered in the presence of inflammation lowers vWF and FBG, but fibrinolytic activity is also reduced. As a result, the overall risk of VTE is increased in long-term users. Finally, no studies have assessed haemostatic abnormalities in patients with Addison's disease, although these may present as a consequence of bilateral adrenal haemorrhage, especially in the presence of antiphospholipid antibodies or anticoagulant treatments. The present review aimed to provide a comprehensive overview of the complex alterations produced by GCs in order to develop better screening and prevention strategies against bleeding and thrombosis.

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Section: Platelet Activationmentioning

confidence: 98%

MECHANISMS IN ENDOCRINOLOGY: The spectrum of haemostatic abnormalities in glucocorticoid excess and defect

Isidori

Minnetti

Sbardella

et al. 2015

European Journal of Endocrinology

107

View full text Add to dashboard Cite

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“…On average the stimulatory effect is absent after 12 months following successful surgery for Cushing's syndrome [12]. A direct effect of glucocorticoids on coagulation system parameters has been confirmed in a number of studies [28][29][30][31]. A significant in SCS patients and found that vWF activities were higher in these patients compared to healthy controls.…”

Section: Discussionmentioning

confidence: 87%

Activity of selected coagulation factors in overt and subclinical hypercortisolism

Świątkowska−Stodulska

Skibowska-Bielińska

Wiśniewski

et al. 2015

Endocr J

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“…No previous reports described treatment of Addison's disease with corticosteroids only; it was attempted in this doe as the sole option to lengthen the animal's life. As the doe deteriorated shortly after discharge, while the long acting corticosteroids were still supposed to have adequate circulating levels, inadequate stress response was not considered to be the primary cause of her death but could have contributed to the pain and discomfort of this animal because of its role in promoting a hypercoagulable state [19] leading to thrombosis of the caudal vena cava.…”

Section: Discussionmentioning

confidence: 99%

Addisonian Crisis due to Metastatic Adenocarcinoma in a Pygmy Goat

Nógrádi

Koehne

Mohr

et al. 2013

Case Reports in Veterinary Medicine

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A 15-year-old Pygmy doe was evaluated for acute onset of lethargy, anorexia, and weakness. Adrenal insufficiency was diagnosed based on physical exam findings, blood work abnormalities (hyponatremia, hyperkalemia, azotemia, and hypoglycemia), and lack of cortisol response to the ACTH stimulation test. Abdominal ultrasound exam revealed an intact urinary tract and multiple bilateral peri-renal masses. The doe was treated with intravenous fluid therapy aimed at correcting the electrolyte abnormalities and intravenous corticosteroids. She responded favorably to medical therapy in 24 hours, with dramatic improvement in attitude and appetite. Fluid therapy was discontinued, and the doe was discharged from the hospital on steroid supplementation. She deteriorated rapidly and died at home 36 hours after discharge. Necropsy results revealed metastatic adenocarcinoma originating from the uterus that infiltrated the urinary bladder, the region of the adrenal glands, the left and right renal lymph nodes, the left kidney, the caudal vena cava, the submandibular lymph nodes, the diaphragm, the lungs, and the omentum. Addison's syndrome in ruminants should be considered as an uncommon sequel of intra-abdominal neoplastic processes.

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Effect of high-dose dexamethasone on endothelial haemostatic gene expression and neutrophil adhesion

Cited by 44 publications

References 53 publications

MECHANISMS IN ENDOCRINOLOGY: The spectrum of haemostatic abnormalities in glucocorticoid excess and defect

MECHANISMS IN ENDOCRINOLOGY: The spectrum of haemostatic abnormalities in glucocorticoid excess and defect

Activity of selected coagulation factors in overt and subclinical hypercortisolism

Addisonian Crisis due to Metastatic Adenocarcinoma in a Pygmy Goat

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