Effect of high-dose intravenous immunoglobulin on suppression of alloantibodies against hla in highly sensitized transplant candidates

Preventing sensitization with mycophenolate mofetil in a pediatric kidney recipient

“…Immunoabsorption is more costly, invasive, and its availability is limited (23). High‐dose IV IgG has not been shown to be effective in reduce PRAs in similar situations (24). Of course, ongoing immunosuppression is associated with an increased risk of infection.…”

Anti–Human Leukocyte Antigen Antibodies Are Present in Blood of Blood Donors: Is Therapy With Blood Preparations Safe for Graft Recipients?

“…Due to the multiple pathways of immune modulation effects, IVIGs are used in desensitization procedures and humoral rejection episodes. However, not all treatment effects are satisfactory and in some cases even led to an increase of immunoglobulin levels [10,27,28].…”

A Positive Crossmatch and Treatment with IvIg

“…Among the methods that have been used for 'desensitization' of potential transplant recipients, administration of IvIg has played a role for many years. This treatment has been shown to effectively decrease serum antibodies, although it is not uniformly reliable, and was found more effective by some authors (4) than others (5). The principle of successful immune modulation by IvIg in the transplant setting was further supported by data showing an impressive post-transplant treatment response in patients with steroid-resistant rejection (6).…”