Effect of high-dose intravenous vitamin C on inflammation in cancer patients

Mikirova, Nina; Casciari, Joseph J.; Rogers, A. S.; Taylor, Paul

doi:10.1186/1479-5876-10-189

Cited by 138 publications

(134 citation statements)

References 72 publications

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“…Previously, a significant decrease in CA 15.3 was observed following immunotherapy for breast cancer (45). Furthermore, the correlation between CA 15.3 and CRP has been documented in different types of cancer patients after the inhibition of pro-inflammatory pathways by vitamin C (46). To the best of our knowledge, this is the first study demonstrating such a correlation in breast cancer.…”

Section: Discussionsupporting

confidence: 47%

CXCL8, IL-1β and sCD200 are pro-inflammatory cytokines and their levels increase in the circulation of breast carcinoma patients

et al. 2016

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Abstract. The influence of biomarkers on carcinogenesis has been investigated extensively. Whether they promote carcinogenesis or work against cancer development remains to be elucidated. To the best of our knowledge, the novel molecule cluster of differentiation 200 (CD200) has not been studied on human breast cancer subjects. The present study aimed to evaluate interleukin-1β (IL-1β), C-X-C motif chemokine ligand 8 (CXCL8), cancer antigen 15.3 (CA 15.3) and the soluble CD200 (sCD200) levels in the serum samples of breast carcinoma patients in order to predict their role in breast carcinoma. The subjects included individuals with early and advanced stage breast cancers, as well as healthy controls. Commercially available ELISA kits were used to measure the serum concentrations of sCD200, IL-1β, CXCL8, CA 15.3, C-reactive protein (CRP) and leukocyte count. A total of 130 subjects were recruited; 50 early stage cancer, 50 advanced stage and 30 control subjects. Serum sCD200, CXCL8, IL-1β and CRP levels were significantly higher in the early as well as the advanced stage breast cancer patients compared to the control group. The level of CA 15.3 was statistically different between early and advanced stage. There were significant positive correlations between IL-1β and CXCL8, and IL-1β and serum sCD200 levels in the control group. These correlations did not persist in the early or the advanced stage cancer groups except CRP and CA 15.3, but new correlations appeared between serum sCD200 level and leukocyte count for advanced stage breast cancer group. Multivariate regression correlation analysis revealed positive correlation between IL-1β and sCD200; and IL-1β and CXCL8. In conclusion, sCD200, CXCL8, CA 15.3 and IL-1β are proinflammatory molecules and their levels are influenced in breast cancer patients.

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Section: Discussionsupporting

confidence: 47%

CXCL8, IL-1β and sCD200 are pro-inflammatory cytokines and their levels increase in the circulation of breast carcinoma patients

et al. 2016

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“…Vitamin C is a potent antioxidative agent, it influences mitochondrial function by decreasing the generation of reactive oxygen species (ROS) through stimulation of the activity of superoxide dismutase and glutathione peroxidase and alteration of the activity of the electron transport chain [16]. Vitamin C also has anti-inflammatory properties [17]. Some data indicate that, in rodents, dietary supplementation with vitamin C could prevent fat deposition induced by a HF diet.…”

Section: Prace Oryginalnementioning

confidence: 99%

Wpływ L-argininy i kwasu askorbinowego na zawartość tłuszczu trzewnego oraz stężenia metaloproteinaz 2 i 9 u szczurów karmionych dietą wysokotłuszczową

Kujawska-Łuczak

Suliburska

Markuszewski

et al. 2015

Endokrynologia Polska

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Introduction: L-arginine (L-arg) and vitamin C supplementation may decrease fat accumulation and have a favourable effect on carbohydrate metabolism. This is partly caused by matrix metalloproteinases (MMPs), which are involved in adipocyte development and remodelling. Our study evaluated the effects of L-arg and vitamin C supplementation on the content of visceral fat (VF%), activity of MMPs, and insulin resistance (IR) in rats fed a high-fat diet (HFD). Material and methods:The experiment was performed using 48 Wistar rats divided into four groups: Group 1 was fed a standard diet, Group 2 a HFD, Group 3 a HFD supplemented with L-arg (A), and Group 4 a HFD supplemented with L-arg and vitamin C (AC). The animals were euthanized after six weeks. The concentrations of serum glucose, insulin, MMP-2, and MMP-9, as well as IR by Homeostatic Model Assessment (HOMA) and VF% were measured. Results: Statistically significant increases in VF%, MMP-2, MMP-9, insulin, and HOMA-IR levels were observed in the HFD group when compared to the control group. A smaller increase in VF%, insulin, and HOMA-IR was seen in Group 3 (A) and 4 (AC). L-arg supplementation protected against increases in MMP-2 and MMP-9 in Group 3 (A) and 4 (AC). Conclusions:1. L-arginine could protect from an increase in visceral fat through a change in the activity of MMPs and amelioration of insulin sensitivity in rats fed a HFD.

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“…IVC therapy reduced CRP levels and decreased plasma concentrations of several inflammatory and angiogenic cytokines; moreover, these decreases correlated with reductions in the levels of tumor markers [15,30]. Prostate cancer may be a particularly promising candidate for IVC therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Several mechanisms were proposed such as the effects of high doses of vitamin C on angiogenesis, suppression of inflammation, modulation of gene expression, and improvement of immune cells' functioning [13][14][15][16]. There are in vitro and animal studies that showed that high-dose vitamin C induces pro-oxidant effects and selectively kills cancer cells [17,18].…”

Section: Introductionmentioning

confidence: 99%

Changes in the rate of PSA progression and the level of alkaline phosphatase during high dose vitamin C treatment of patients with prostate cancer

Mikirova¹,

Hunninghake²

2017

FFHD

Self Cite

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Citation: Mikirova N., Hunninghake R., Changes in the rate of PSA progression and the level of alkaline phosphatase during high dose vitamin C treatment of patients with prostate cancer. Functional Foods in Health and Disease 2017; 7(7): 511-528 ABSTRACT Introduction: Intravenously administered vitamin C (IVC) may have anti-cancer and antiinflammatory properties. Many studies demonstrated evidence of a good safety profile of IVC treatments and improvement of the quality of life in cancer patients. IVC has been proposed as a treatment for cancer as an adjuvant in conjunction with other therapies. To investigate high dose ascorbic acid potential in treating prostate cancer, a retrospective study was conducted using clinical data from the Riordan Clinic database . Methods:We collected data, when available, on the following patient characteristics at diagnosis and during the courses of IVC therapy: age, tumor stage, Gleason score, serum prostate specific antigen (PSA) and alkaline phosphatase (ALP) levels, and location of metastases. In particular, PSA, ALP, and C-reactive protein (CRP) levels are analyzed in prostate cancer patients given IVC therapy during several years. Results:We found that PSA, CRP, and ALP correlate with tumor staging as measured by Gleason scores. Moreover, peak plasma ascorbate levels attained during the patients first IVC infusions are reduced in patients with elevated PSA and CRP levels. Tracking the changes in PSA and ALP with time in patients for whom data are available indicates that the rate of increase in these variables over time can be reduced by incorporating IVC therapy and by increasing the frequency of IVC treatments. Conclusion: There appeared to be a relation between the frequency of IVC treatments and the rate of PSA change, with PSA rate of growth decreasing as the frequency of IVC increases. Further research into the use of IVC in prostate cancer patients is warranted.

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Effect of high-dose intravenous vitamin C on inflammation in cancer patients

Cited by 138 publications

References 72 publications

CXCL8, IL-1β and sCD200 are pro-inflammatory cytokines and their levels increase in the circulation of breast carcinoma patients

CXCL8, IL-1β and sCD200 are pro-inflammatory cytokines and their levels increase in the circulation of breast carcinoma patients

Wpływ L-argininy i kwasu askorbinowego na zawartość tłuszczu trzewnego oraz stężenia metaloproteinaz 2 i 9 u szczurów karmionych dietą wysokotłuszczową

Changes in the rate of PSA progression and the level of alkaline phosphatase during high dose vitamin C treatment of patients with prostate cancer

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