Effect of High-Dose Sodium Selenite Therapy on Polymorphonuclear Leukocyte Apoptosisin Non-Hodgkin's Lymphoma Patients

Asfour, Inas A.; Shazly, Sherin El; Fayek, Manal Hashem; Hegab, Hany M.; Raouf, Soha; Moussa, Mohamed A. R.

doi:10.1385/bter:110:1:19

Cited by 25 publications

(17 citation statements)

References 17 publications

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“…Selenium is an essential trace element with the potential chemopreventive effects against various cancers (6)(7)(8)(9). Our previous work has shown that 20 μM sodium selenite can induce apoptosis in NB4 cells (10).…”

Section: Introductionmentioning

confidence: 99%

Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells

Ren¹,

Huang²,

Liu³

et al. 2009

BMB Reports

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Selenium possesses the chemotherapeutic feature by inducing apoptosis in cancer cell with trivial side effects on normal cells. However, the mechanism in which is not clearly understood. Emerging evidence indicates the overlaps between the autophagy and the apoptosis. In this study, we have investigated the role of autophagy in selenium-induced apoptosis in NB4 cells. We find that autophagy is suppressed in NB4 cells treated by sodium selenite, as measured by electron microscope, acridine orange staining and western blot. Moreover, selenite combined with autophagy inhibitor contributes to the up-regulation of apoptosis, while the PI3K/Akt signaling pathway is down-regulated. Consistently, when the inhibitor of PI3K was applied, the autophagic level significantly decreased. In summary, sodium selenite increases NB4 cell apoptosis by autophagy inhibition through PI3K/Akt, and the inhibition of autophagy contributes to the up-regulation of apoptosis. [BMB reports 2009; 42(9): 599-604]

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Section: Introductionmentioning

confidence: 99%

Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells

Ren¹,

Huang²,

Liu³

et al. 2009

BMB Reports

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“…A small clinical randomized study in patients with non-Hodgkin's lymphoma showed that Se supplementation during chemotherapy increases the percentage of cases with a reduction of lymphadenopathy, and decreases splenic size and bone marrow infiltration [15]. Further prospective clinical trials showed that Se can reduce toxicities of chemotherapy in patients with solid tumors and hematological malignancies [15,16,17,18,19,20]. …”

mentioning

confidence: 99%

Serum Selenium Deficiency in Patients with Hematological Malignancies: Is a Supplementation Study Mandatory?

Muecke

Micke²,

Schomburg

et al. 2014

Acta Haematol

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“…Asfour et al (2006) demonstrated that the sodium selenite administration to humans with non-Hodgkin's lymphoma and treated by chemotherapy resulted in a signiϐicant reduction in neutrophils apoptosis compared to those who were not supplemented with sodium selenite. The viable neutrophils (nonapoptotic) markedly improved the overall post therapy neutropenic phase and decreased signiϐican-tly possible life threatening infections.…”

Section: Resultsmentioning

confidence: 99%

Efeito da suplementação in vitro de selênio sobre neutrόfilos do leite e sanguíneos em vacas leiteras

Souza¹,

Blagitz²,

Latorre³

et al. 2012

Pesq. Vet. Bras.

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The study was designed to assess the effects of in vitro selenium addition on intracellular hydrogen peroxide production by neutrophils from the milk and blood of dairy cows. Blood from 10 dairy cows and 20 milk samples from ϐive dairy cows were incubated with 0 mg (control) or 10μM of sodium selenite. Then, milk and blood neutrophils were submitted for evaluation of intracellular hydrogen peroxide production by ϐlow cytometry using 2',7'-dichloroϐluorescein diacetate as a probe. The selenium status of the animals was evaluated by determination of the blood glutathione peroxidase activity. The results of the present work showed that in vitro selenium supplementation leads to an enhancement in intracellular hydrogen peroxide production, which indicates an improvement in the bactericidal effects of blood and milk neutrophils even in cows with a selenium-adequate status. Thus, the present study showed that in vitro Se supplementation leads to an enhancement in intracellular hydrogen peroxide production, indicating an improvement in the bactericidal effects of blood and milk neutrophils in cows with Se-adequate status. A determinação da produção intracelular de peróxido de hidrogênio se deu por citometria de ϐluxo através da utilização do 2´,7´ diclorodihidroϐluoresceína diacetato como sonda. A mensuração do conteúdo de selênio foi avaliada pela atividade da glutationa peroxidase eritrocitária. Os leucócitos polimorfonucleares tanto sanguíneos quanto do leite apresentaram signiϐicativo aumento na produção intracelular de H 2 O 2 com a suplementação in vitro de selênio. Desta forma, o presente estudo apontou para aumento da produção intracelular de H 2 O 2 , indicando aumento da capacidade microbicida dos leucócitos polimorfonucleares sanguíneos e lácteos mesmo em animais com níveis adequados de selênio.

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Effect of High-Dose Sodium Selenite Therapy on Polymorphonuclear Leukocyte Apoptosisin Non-Hodgkin's Lymphoma Patients

Cited by 25 publications

References 17 publications

Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells

Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells

Serum Selenium Deficiency in Patients with Hematological Malignancies: Is a Supplementation Study Mandatory?

Efeito da suplementação in vitro de selênio sobre neutrόfilos do leite e sanguíneos em vacas leiteras

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