Effect of High-Dose Statin Loading on Biomarkers Related to Inflammation and Renal Injury in Patients Hospitalized With Acute Heart Failure

Abstract

Background: High-dose statin loading is known to reduce periprocedural myocardial infarction and contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention. However, the clinical role of high-dose statin loading in patients with acute heart failure (AHF) remains unknown. Methods and Results:In a prospective, single-center, randomized, controlled, open-label pilot study, patients hospitalized with AHF were randomly assigned to receive oral high-dose atorvastatin loading (80 mg for 3 days, followed by 10 mg/day until discharge) or no statin therapy, on top of optimal HF treatment. The primary outcome measures were changes to the level of biomarkers related to inflammation and renal injury from admission to hospital day 4. No significant changes in the levels of NT-proBNP (−2,627±4,956 vs. −2,981±6,951 pg/ml, P=0. Conclusions: This pilot study showed that oral high-dose atorvastatin loading may be used safely in patients with AHF, but is not effective in reducing the levels of circulating biomarkers related to inflammation and renal injury during hospitalization. (Circ J 2014; 78: 2447 -2454

The Different Cardiovascular Outcomes Between Long-Term Efficacy of Hydrophilic and Lipophilic Statin Therapy in Both Asian Diabetic Sexes

“…10 Statin therapy for CHF was considered controversial in other studies. 11,12 In our study, no benefit was observed in both statin cohorts and both sexes. A 2-year comparison of hydrophilic and lipophilic statin studies showed no significant difference in AMI.…”

Association of venous thromboembolism between hydrophilic and lipophilic statin users among diabetic subjects

“…Due to inconclusive results from prior investigations, there is still controversy regarding the statements. [3][4][5][6][7][8] The relationship between the risk of cardiovascular outcomes and DM is well-known. Despite higher incidence of associated higher morbidity and mortality, venous thromboembolism (VTE) attracts less attention compared to other adverse outcomes among DM subjects.…”

Combination of Urinary Biomarkers Improves Early Detection of Acute Kidney Injury in Patients With Heart Failure

“…35 Furthermore, compared to Cr, present biomarkers reflect the renal dysfunction rapidly and may be more suitable for clinical trials that focus on acute-illness patients. 36 Neutrophil gelatinase-associated lipocalin is a 25-kDa protein of the lipocalin family that is produced by neutrophil and also expressed in the kidney, liver, and epithelial cells during acute pathologic states such as inflammation, infection, intoxication, ischemia, and neoplastic transformation. 37 In AKI, both upregulated NGAL expression in the distal nephron and impaired proximal tubular NGAL reabsorption contribute to increased urinary and plasma NGAL levels.…”