Effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome: a randomized controlled double-blind clinical trial

Salekzamani, Shabnam; Mehralizadeh, Hossein; Ghezel, Aymaral; Salekzamani, Yaghoub; Jafarabadi, Mohammad Asghari; Bavil, Abolhassan Shakeri; Gargari, Bahram Pourghassem

doi:10.1007/s40618-016-0507-8

Cited by 65 publications

(88 citation statements)

References 46 publications

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“…Our study indicated that vitamin D supplementation did not change the anthropometric indexes, as illustrated in previous studies (Salekzamani et al, ; Sharifi, Amani, Hajiani, & Cheraghian, ; Zittermann et al, ). Although the treatment was not in different seasons (the last month of spring and summer), one of the limitations of this study was seasonal change that can affect the outcome.…”

Section: Discussionsupporting

confidence: 86%

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Fazelian

Paknahad

Khajehali³

et al. 2018

J Food Biochem

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Type 2 diabetes (T2DM) is a global problem that increases the risk of inflammation and hormonal dysfunction. The purpose of this study was to determine the effect of vitamin D on inflammatory biomarkers, omentin, and vaspin in diabetic women with anxiety. In this study, 51 women with T2DM were allocated to receive one oral pearl of 50,000 IU vitamin D3 (26) or a placebo (25) fortnightly for 16 weeks. Anthropometric indices, dietary intake, high sensitivity C‐reactive protein (hs‐CRP), Interleukin 10 (IL‐10), vaspin, and omentin were measured at the baseline and after 16‐weeks supplementation. Serum hs‐ CRP was reduced (p = 0.01) and IL‐10 concentrations was increased (p = 0.04) in intervention group. Vitamin D marginally increased serum levels of omentin (p = 0.06), however, vaspin did not change post‐intervention. According to subgroup analysis, omentin levels increased significantly in participants with lower baseline serum vitamin D (p = 0.008). Vitamin D can improve anti‐inflammatory biomarkers in diabetic patients. Practical applications Diabetes is prevalent in the world. Inflammation in diabetic patients causes other chronic diseases such as cardio vascular disease. Adipose tissue contributes to the regulation of metabolism and insulin sensitivity. Two hormones secreted from adipose tissue that play an important role in insulin function and anti‐inflammatory activity. Vitamin D, can improve insulin sensitivity and inflammation via effects on the adipocytokines secretion. For the first time, a trial study conducted to determine the effect of vitamin D on inflammation and the serum levels of omentin and vaspin.

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Section: Discussionsupporting

confidence: 86%

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Fazelian

Paknahad

Khajehali³

et al. 2018

J Food Biochem

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“…73,74 A recent Iranian study noted that vitamin D supplementation improves vitamin D status and lowers triglyceride levels in patients with MetS. 75 However, a study by George et al demonstrated that vitamin D status is not linked with MetS risk or its components in Black and Indian South Africans, but parathyroid hormone (PTH) is associated with an increased risk of MetS. 33 The association of PTH with MetS was due to its positive correlation with systolic and diastolic blood pressure and waist circumference.…”

Section: Metabolic and Anthropometric Factorsmentioning

confidence: 99%

“…76,77 The association of pro-inflammatory markers and MetS has been confirmed in adolescent Egyptians, 78 but this relationship and the link of other biomarkers with MetS needs to be confirmed in adult sub-Saharan African populations.…”

Section: Metabolic Syndrome In South Africamentioning

confidence: 99%

Review: Metabolic Syndrome in Black South African Women

Gradidge

Crowther

2017

Ethn Dis

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The prevalence of metabolic syndrome is increasing in African populations, and is particularly high in Black South African women (42%) vs women in the United Kingdom (23%) and the United States of America (36%). This population group is also known to have the highest prevalence of obesity in the sub-Saharan African region (42%), and consequently, a high risk of non-communicable diseases. In this article, we discuss factors (abdominal subcutaneous fat, visceral fat, lean mass, adiponectin, leptin, vitamin D, smoking and menopausal status) that have been investigated for their possible association with metabolic syndrome in African women, and discuss some recommendations for management of the syndrome. In particular, the infrastructural development of HIV/AIDS clinics in South Africa provides an ideal integrated platform to cater to the treatment needs of patients with multiple chronic morbidities. Ethn Dis. 2017(27):189-200; doi:10.18865/ed.27.2.189

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“…Nagpal et al [27] also found that no improvement was seen in HOMA-IR; however, there was a significant elevation in insulin sensitivity following supplementation with high-dose vitamin D for 6 weeks in healthy obese Indian participants. Supplementation with high-dose vitamin D (50,000 IU/week) for 16 weeks decreased triglycerides levels without change in other cardiometabolic risk factors in participants with metabolic syndrome [28]. However, vitamin D supplementation for ≥6 months has been found to not affect glucose metabolism and lipid profiles among subjects who were overweight [29], obese [30], or older adults [31].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Vitamin D Supplementation and the Effects on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2 or 3: A Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2018

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Objective: This study was conducted to evaluate the effects of vitamin D supplementation on the recurrence and metabolic status of patients with cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3). Methods: This randomized, double-blind, placebo-controlled trial was carried out among 58 women diagnosed with CIN2/3. Participants were randomly assigned into 2 groups to receive either 50,000 IU vitamin D3 (n = 29) or placebo (n = 29) every 2 weeks for 6 months. Results: The recurrence rate of CIN1/2/3 was 18.5 and 48.1% in the vitamin D and placebo groups respectively (p = 0.02). When we excluded CIN1, the recurrence rate of CIN2/3 became nonsignificant. Vitamin D supplementation significantly decreased fasting plasma glucose (–7.8 ± 9.2 vs. –1.1 ± 8.6 mg/dL, p = 0.006) and insulin levels (–3.2 ± 4.8 vs. –0.9 ± 3.4 µIU/mL, p = 0.03), and significantly increased quantitative insulin sensitivity check index (0.01 ± 0.02 vs. 0.002 ± 0.01, p = 0.02) compared with the placebo. Additionally, there was a significant decrease in high-sensitivity C-reactive protein (–815.3 ± 1,786.2 vs. 717.5 ± 1,827.3 ng/mL, p = 0.002) and a significant increase in total antioxidant capacity (113.4 ± 137.4 vs. –53.7 ± 186.7 mmol/L, p < 0.001) following the supplementation of vitamin D compared with the placebo. Conclusions: Vitamin D3 supplementation for 6 months among women with CIN2/3 had beneficial effects on CIN1/2/3 recurrence and metabolic status; however, it did not affect CIN2/3 recurrence.

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Effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome: a randomized controlled double-blind clinical trial

Cited by 65 publications

References 46 publications

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Review: Metabolic Syndrome in Black South African Women

Long-Term Vitamin D Supplementation and the Effects on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2 or 3: A Randomized, Double-Blind, Placebo-Controlled Trial

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