“…However, only for the hypothalamic level has evidence been provided from both in vitro and in vivo experiments (Tenasempere, 2005). It is possible that ghrelin differentially modulates the intracellular actions of LHRH (Fernandez et al, 2004), a finding previously described for peptides involved in the control of LHRH action, such as endothelins (Kauyicska et al, 1991), galanin (Aboutalebi et al, 2011) and NPY (Evans, 1999). Ghrelin significantly decreased hypothalamic LHRH in vitro (Fernandez et al, 2006).…”