Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function

Tan, Bee Ling; Norhaizan, Mohd Esa

doi:10.3390/nu11112579

Cited by 301 publications

(177 citation statements)

References 157 publications

(185 reference statements)

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“…The brain is highly sensitive to oxidation because of the presence of large amounts of unsaturated fatty acids and oxygen, which serve as a substrate for lipid peroxidation. The peroxidation products are the biomarkers of oxidative stress in neurodegenerative diseases 27 . Consistent with the results of these studies, hypertension in rats caused a significant decline in cognitive function 90 days after deoxycorticosterone acetate salt induction, and this decline was found to be associated with increased anti‐oxidative capabilities and increased endothelial dysfunction by increased NO production 15 .…”

Section: Discussionsupporting

confidence: 63%

Lactobacillus plantarumTWK10‐fermented soymilk improves cognitive function in type 2 diabetic rats

et al. 2020

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BACKGROUND: The brain is especially sensitive to diabetes-induced damage. Chronic hyperglycemia can potentially lead to brain dysfunctions, affecting spatial learning and memory. RESULTS: The type 2 diabetes (T2D) rats were administered TWK10-fermented soy milk water extract (WE) and ethanol extract (EE) for 6 weeks. WE and EE treatment attenuated T2D-induced alteration in cognitive function assessed using the Morris water maze. Moreover, administration of WE and EE significantly elevated superoxide dismutase activity (166.96% and 181.21%, P < 0.05, respectively) and reduced malondialdehyde concentration (35.03% and 43.97%, P < 0.05, respectively) in the hippocampus of the rats. Additionally, the calmodulin level and nitric oxide concentration were regulated by WE and EE. CONCLUSION: This study provides scientific evidence that WE and EE enhance anti-oxidative enzyme activity, which subsequently regulates factors associated with cognitive function in T2D rats.

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Section: Discussionsupporting

confidence: 63%

Lactobacillus plantarumTWK10‐fermented soymilk improves cognitive function in type 2 diabetic rats

et al. 2020

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“…Excessive fat intake results in mitochondrial β-oxidation of free fatty acids and excessive electron flow involving cytochrome c oxidase. This leads to overproduction of ROS, which damages proteins, lipids, and DNA, thereby disturbing the functions of certain cells [ 25 ]. A high-fat diet causes fat deposition in the body [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of DNA Methylation and Oxidative Changes in the Heart and Brain of Rats Receiving a High-Fat Diet Supplemented with Various Forms of Chromium

Dworzański

Cholewińska

Fotschki

et al. 2020

Animals

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The aim of the study was to determine how feeding rats a high-fat diet supplemented with various forms of chromium affects DNA methylation and oxidation reactions as well as the histology of heart and brain tissue. The rats received standard diet or high-fat diet and chromium at 0.3 mg/kg body weight (BW) in form of chromium (III) picolinate, chromium (III)-methionine, or nano-sized chromium. The content of malondialdehyde (MDA), protein carbonyl (PC), and 8-hydroxydeoxyguanosine (8-OHDG), the level of global DNA methylation and the activity of selected DNA repair enzymes were determined in the blood. In the brain and heart, the content of MDA, PC, 8-OHDG, and levels of global DNA methylation were determined. The brain was subjected to histological examination. The use of a high-fat diet was found to intensify epigenetic changes and oxidation reactions in the heart and brain. It was concluded that epigenetic changes and oxidation of lipids, proteins, and DNA in the heart and brain of rats resulting from the use of a high-fat diet cannot be limited by supplementing the diet with chromium. It was established that the use of chromium to supplement a high-fat diet intensifies the negative epigenetic and oxidative changes in the heart and brain, especially in the case of chromium nanoparticles.

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“…The decrease in cerebral blood flow will cause the disorder of cerebral auto-regulation mechanism, which may lead to cerebral degenerative abnormalities, such as cognitive dysfunction. Moreover, cognitive function changes are involved in many inflammatory response processes and oxidative stress [15,16]. RDW is considered to be a biochemical marker of pre-inflammatory state.…”

Section: Introductionmentioning

confidence: 99%

Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting

Wan

Luo

et al. 2020

Bioscience Reports

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We assessed the relationship between red blodd cell distribution width (RDW) and postoperative cognitive dysfunction (POCD) after coronary artery bypass grafting (CABG) in patients who usually had obvious hemodynamic changes. We enrolled 362 coronary heart disease patients who received CABG. POCD was assessed through neuropsychological examination at 21 days after operation. Demographics, history of diseases, blood biochemical parameters and perioperative data were collected. The receiver operating characteristic (ROC) curve was used to find the best cut-off value of RDW for diagnosis of POCD. Logistic regression was used to explore the relationship between RDW and POCD. The 21-day incidence of POCD in patients receiving CABG was 27.1% (98/362). The RDW of POCD patients was significantly higher than in the non-POCD patients (17.4 vs. 13.2). The sensitivity and specificity of RDW for predicting POCD were 82.7 and 64.8%, respectively. The POCD patients also tended to be older and had higher fasting plasma glucose, hypersensitive c-reactive protein, tumor necrosis factor-α, white blood cell levels and longer surgery time. No significant differences were found in other parameters. The 21-day neuropsychological test results were better in the POCD patients than the non-POCD patients. After adjustment of potential factors, the preoperative high RDW was still associated with an increased risk of POCD (odds ratio (OR) = 2.52, 95% confidence interval (CI): 1.28–4.31). Our study indicates that preoperative RDW is significantly elevated in POCD patients receiving CABG. The elevated preoperative RDW is associated with an increased risk of POCD and preoperative RDW can be an independent predictor of POCD.

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Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function

Cited by 301 publications

References 157 publications

Lactobacillus plantarumTWK10‐fermented soymilk improves cognitive function in type 2 diabetic rats

Lactobacillus plantarumTWK10‐fermented soymilk improves cognitive function in type 2 diabetic rats

Assessment of DNA Methylation and Oxidative Changes in the Heart and Brain of Rats Receiving a High-Fat Diet Supplemented with Various Forms of Chromium

Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting

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