Effect of high-intensity interval training on patient-reported outcomes and physical function in women with breast cancer receiving anthracycline-based chemotherapy

Lee, Kyuwan; Norris, Mary K.; Wang, Ellice; Dieli-Conwright, Christina M.

doi:10.1007/s00520-021-06294-7

Cited by 28 publications

(43 citation statements)

References 31 publications

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“…Three studies did not report disease stage ( 61 , 85 , 89 ). The sample size across the 17 completed studies ranged from 20 to 246, with six trials focusing only on Black women ( 61 , 63 – 65 , 68 , 89 ), five only on Latina women ( 57 , 58 , 69 , 85 , 87 ) and six including both groups ( 59 , 60 , 62 , 66 , 67 , 86 ). Included trials were geographically limited to the Northeast USA (n=8, NY, NC, DC, NJ), Texas (n=4), California (n=3), Arizona (n=2), Illinois (n=2), Puerto Rico (n=1), Massachusetts (n=1) and one ongoing at three sites (California, New York, and Pennsylvania).…”

Section: Resultsmentioning

confidence: 99%

“…Lee et al. conducted an 8-week, two-arm randomized pilot study of a high intensity interval training intervention vs. waitlist control arm on patient reported outcomes (quality of life, cancer-related fatigue, and mindfulness) and physical function among 30 patients with breast cancer (73% Latina) undergoing anthracycline-based chemotherapy ( 86 ). No cultural adaptations were reported.…”

Section: Resultsmentioning

confidence: 99%

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Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review

et al. 2023

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BackgroundA growing number of lifestyle interventions are being developed to promote weight loss and adoption of a healthful lifestyles among breast cancer survivors; yet Black and Latina women remain underrepresented.PurposeWe performed a scoping review of the available peer-reviewed literature to describe and compare the content, design, methods, and primary outcomes of current diet and/or physical activity (PA) interventions after a breast cancer diagnosis among Black and Latina women.MethodsWe queried PubMed, EMBASE, CINAHL, MEDLINE, and Clinicaltrials.gov up to October 1, 2022, to identify all randomized controlled trials of diet and/or PA after diagnosis of breast cancer with a majority (>50%) of Black or Latina participants.ResultsTwenty-two randomized controlled trials were included in this review (five efficacy, twelve pilot, five on-going). Nine trials were among Latinas (two diet, four PA, and three diet/PA), six among Blacks (one PA and five diet/PA) and seven included both populations (five PA and two diet/PA), all of which examined different endpoints. Two of the five efficacy studies achieved their a priori outcome (one diet trial improved short term dietary intake; one PA trial achieved clinically significant improvements in metabolic syndrome score), both in Latinas. Eight pilot trials intervened on both diet and PA and three of them found favorable behavioral changes. Three (two for Latinas and one for Blacks) out of the nine diet and PA trials and three (all for Latinas) efficacy trials incorporated a culturally focused approach (i.e., traditional foods, music, Spanish content, bicultural health coaches, spirituality). Overall, four trials, including one efficacy trial, had one-year follow-up data, with three finding sustained behavior change. Electronic/mobile components were incorporated in five trials and one involved informal care givers. Most of the trials were geographically limited to the Northeast USA (n=8, NY, NC, DC, NJ) and Texas (n=4).ConclusionsMost of the trials we identified were pilot or feasibility studies and of short duration, demonstrating the need for large randomized controlled efficacy lifestyle interventions among Black and Latina breast cancer survivors. Culturally tailored programing was limited but is an important component to incorporate in future trials in these populations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review

et al. 2023

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“…Por lo tanto, teniendo en cuenta todos estas variables comentadas anteriormente, podemos observar una mejora en la calidad de vida de las personas con cáncer de mama (Lee et al, 2021;Pagola et al, 2020;Schmitt et al, 2016a;Schulz et al, 2018).…”

Section: Semanasunclassified

Descifrando el papel del entrenamiento interválico de alta intensidad en el cáncer de mama: revisión sistemática (Deciphering the role of high-intensity interval training in breast cancer: systematic review)

García

2021

Retos

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El cáncer de mama es uno de los más extendidos y proliferativo a nivel mundial. Esto provoca un gran impacto en el gasto sanitario. Aunque se sabe que el ejercicio físico mejora diferentes aspectos relacionados con el cáncer, hoy en día se desconoce qué tipo de entrenamiento o intensidad es mejor para esto. El propósito de esta revisión sistemática fue conocer los efectos fisiológicos, cognitivos y económicos que aporta el HIIT a este tipo de pacientes. La búsqueda se realizó en las bases de datos PubMed, Web of Science, MEDLINE y Scopus, a partir de los descriptores “cancer, high intensity interval training y breast”. De los 78 obtenidos inicialmente, 32 cumplieron todos los criterios de inclusión. Los estudios analizados se centran principalmente en añadir un programa HIIT al tratamiento de personas que padece, han padecido o tiene algo riesgo de padecerlo viendo efectos positivos a nivel de capacidades físicas, cognitivo y financiero. Este método es seguro y factible, y conlleva un aumento de la calidad de vida de estos pacientes. Además, puede mejorar las capacidades físicas, su calidad de vida, se reducen las tasas de finalización del tratamiento, hospitalización y gasto sanitario. Estos efectos beneficiosos deben ser tenidos en cuenta por los profesionales del ámbito médico, fisioterapeutas y profesionales en el deporte en cuanto a su implementación en estos pacientes. Summary. Breast cancer is one of the most widespread and proliferative cancers worldwide. This has a great impact on healthcare spending. Although it is known that physical exercise improves different aspects related to cancer, it is currently unknown what type of training or intensity is best for this. The prupose of this systematic review was to find out the physiological, cognitive and economic effects of HIIT for this type of patient. The search was carried out in the databases PubMed, Web of Science, MEDLINE and Scopus, using the descriptors "cancer, high intensity interval training and breast". Of the 78 initially obtained, 32 met all the inclusion criteria. The studies analysed focus mainly on adding a HIIT programme to the treatment of people who suffer, have suffered or are at risk of suffering from cancer, seeing the positive effects on physical, cognitive and financial capacities. This method is safe and feasible, and leads to an increase in the quality of life of these patients. In addition, it can improve physical abilities and quality of life, reduce treatment completion rates, hospitalization and healthcare costs. Its implementation in cancer patients should be taken into account by professionals in the medical field, as well as physiotherapists and sports professionals, given its benefits.

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“…8 We previously reported the feasibility and positive effect of HIIT on physical function atherosclerosis-related biomarkers and quality of life among breast cancer patients undergoing anthracycline chemotherapy. [9][10][11] While HIIT has been proven to be beneficial for MetS variables in other clinical populations, to the best of our knowledge, no prior study has investigated the effects of HIIT on MetS in breast cancer patients undergoing anthracycline chemotherapy. The purpose of this secondary analysis was to determine the effects of an 8 weeks HIIT intervention on MetS and associated biomarkers in patients with breast cancer undergoing anthracycline chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

High‐intensity interval training improves metabolic syndrome in women with breast cancer receiving Anthracyclines

Gonzalo‐Encabo

Christopher

Lee

et al. 2022

Scandinavian Med Sci Sports

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Introduction Anthracycline chemotherapy is a frequent treatment for breast cancer, whereas it can increase risk of physiologic side‐effects, such as metabolic syndrome (MetS). Exercise has been used as a non‐pharmacological strategy to decrease MetS. Specifically, high‐intensity interval training (HIIT) has been shown to improve MetS in patients with diabetes or cardiac rehabilitation patients; however, the effects of HIIT on MetS and associated biomarkers in patients with breast cancer receiving anthracycline chemotherapy have not been previously explored. Therefore, we purposed to determine the effects of HIIT on MetS in breast cancer patients undergoing anthracycline chemotherapy. Methods In total, 30 patients with breast cancer were recruited prior to initiating treatment and randomized into HIIT (n = 15) or control (n = 15). The HIIT group attended supervised cycling sessions 3 days/week for 8 weeks. MetS was assessed by waist circumference, blood pressure, fasting levels of high‐density lipoprotein cholesterol (HDL–C), triglycerides, and glucose. Circulating levels of MetS‐related biomarkers were also measured (total cholesterol, insulin, HbA1c, leptin, adiponectin, and c‐reactive protein). Results After 8 weeks, MetS z‐score was significantly improved in the HIIT group compared with controls (−7.60, 95% CI: −9.08 to −6.13, p < 0.001). MetS variables (HDL–C, glucose, and triglycerides) and circulating levels of MetS‐related biomarkers were significantly improved in the HIIT group compared with controls (p < 0.001). Non‐significant differences were found in body composition outcomes at the end of the study. Conclusions HIIT may be an effective strategy to improve MetS in breast cancer patients undergoing anthracycline chemotherapy. Furthermore, changes in MetS were independent of changes in body composition.

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Effect of high-intensity interval training on patient-reported outcomes and physical function in women with breast cancer receiving anthracycline-based chemotherapy

Cited by 28 publications

References 31 publications

Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review

Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review

Descifrando el papel del entrenamiento interválico de alta intensidad en el cáncer de mama: revisión sistemática (Deciphering the role of high-intensity interval training in breast cancer: systematic review)

High‐intensity interval training improves metabolic syndrome in women with breast cancer receiving Anthracyclines

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