Effect of high potassium diet on endothelial function

Blanch, N.; Clifton, Peter; Petersen, Kristina S.; Willoughby, S.; Keogh, Jennifer B.

doi:10.1016/j.numecd.2014.04.009

Cited by 24 publications

(28 citation statements)

References 29 publications

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“…Furthermore, we previously showed that a high-potassium meal (without sodium) can attenuate postmeal responses in FMD to a low-potassium meal (13). Previous studies that investigated the effect of increasing potassium on fasting FMD have reported mixed results (12,15,29); however, dose appears to play an important role with potassium increases .40 mmol improving endothelial function (14). The current study suggests a high potassium load attenuates postmeal decreases in FMD irrespective of the sodium concentration present.…”

Section: Discussionsupporting

confidence: 49%

“…However, alterations in sodium and potassium intakes are known to alter biological molecules such as adhesion molecules. Increases in dietary sodium increase endothelin-1 expression (9), and increased dietary potassium reduces E-selectin in the short term (12). Berry et al (15) also observed a reduction in fasting intercellular adhesion molecule-1 (ICAM-1) after a high-potassium diet.…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, high potassium intake is associated with lower CVD risk and lower blood pressure (BP), particularly in hypertensive populations and populations with higher sodium intake (11). Increased dietary potassium improves fasting FMD independent of BP (12), and a high potassium meal can attenuate a postprandial decrease in FMD (13). The effect of high potassium on vascular function measures is unclear (14).…”

Section: Introductionmentioning

confidence: 99%

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Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial

Blanch

Clifton

Petersen

et al. 2015

The American Journal of Clinical Nutrition

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Background: It is known that increased potassium and reduced sodium intakes can improve postprandial endothelial function. However, the effect of increasing potassium in the presence of high sodium in the postprandial state is not known. Objective: We aimed to determine the effect of high potassium and high sodium on postprandial endothelial function as assessed by using flow-mediated dilatation (FMD) and arterial compliance as assessed by using pulse wave velocity (PWV) and central augmentation index (AIx). Design: Thirty-nine healthy, normotensive volunteers [21 women and 18 men; mean 6 SD age: 37 6 15 y; BMI (in kg/m 2 ): 23.0 6 2.8] received a meal with 3 mmol K and 65 mmol Na (low-potassium, high-sodium meal (LKHN)], a meal with 38 mmol K and 65 mmol Na [high-potassium, high-sodium meal (HKHN)], and a control meal with 3 mmol K and 6 mmol Na (low-potassium, low-sodium meal) on 3 separate occasions in a randomized crossover trial. Brachial artery FMD, carotid-femoral PWV, central AIx, and blood pressure (BP) were measured while participants were fasting and at 30, 60, 90, and 120 min after meals. Results: Compared with the LKHN, the addition of potassium (HKHN) significantly attenuated the postmeal decrease in FMD (P-meal by time interaction , 0.05). FMD was significantly lower after the LKHN than after the HKHN at 30 min (P , 0.01). AIx decreased after all meals (P , 0.05). There were no significant differences in AIx, PWV, or BP between treatments over time. Conclusion: The addition of potassium to a high-sodium meal attenuates the sodium-induced postmeal reduction in endothelial function as assessed by FMD. This trial was registered at

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial

Blanch

Clifton

Petersen

et al. 2015

The American Journal of Clinical Nutrition

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“…Berry et al found in female participants only, Intercellular Adhesion Molecule 1 (ICAM-1) was significantly worse after 6 weeks of 40 mmol K (from fruit and vegetables) than on the control treatment [28]. We have recently shown that an increase in dietary potassium (48 mmol) from bananas and potatoes significantly reduced serum E-selectin [26]. In contrast in a study with a high dose of daily potassium supplementation (100 mmol/ d) which increased plasma aldosterone there were no chanced in ET-1 [54].…”

Section: Potassium and Biochemical Markers Of Endothelial Dysfunctionmentioning

confidence: 87%

“…We have recently shown in a group of healthy adults, that a 36 mmol potassium load can attenuate the postprandial reduction in FMD within 2 h [25]. Furthermore an increase of 48 mmol/d in potassium intake achieved by including bananas and potatoes in place of apples and rice significantly improved fasting FMD after only one week [26]. In addition, a study by He et al demonstrated that fasting FMD was significantly improved following 4 weeks of 64 mmol/d potassium chloride and 64 mmol/d potassium bicarbonate compared to placebo [27].…”

Section: Eligibility Criteriamentioning

confidence: 92%

A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

Blanch

Clifton

Keogh

2015

Nutrition, Metabolism and Cardiovascular Diseases

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Mineral and fatty acid contents of maize kernels with different levels of polyembryony

et al. 2020

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Background and objectives Maize (Zea mays) is a cereal of great commercial importance around the world. It has been reported that maize presents polyembryony (PE), which is described as the appearance of two or more seedlings from a germinated seed. Minerals and fatty acids (FA) play important roles in the growth and development of plants and animals. The objective of this work was to determine the minerals and FA content in embryo and endosperm of 32 maize genotypes kernels with different levels of PE (high [NAP], low [NBP], and nonpolyembryonic [T]). Findings The polyembryonic genotypes showed higher concentrations of calcium, magnesium, phosphorous, and potassium. In this study, magnesium was only found in the embryo, while in the embryo of NAP genotypes were found the highest content of K (1,834 mg/kg) and P (656 mg/kg). In contrast, the highest amount of Mg (216 mg/kg) was found in the embryo of NBP genotypes. On the other hand, the highest Ca (251 mg/kg) content was found in the endosperm of NAP genotypes. The highest oil content was observed in NBP‐9‐EM genotype grains with 50.2%, while the highest percentage of oleic (29.10%) and linoleic acid (63.21%) was found in kernels of the NAP‐6‐EM genotype. Conclusions The polyembryonic maize has high mineral content, and some of them have been associated with the human diet; in addition, in these genotypes, high oil content (with the presence of essential FA) was observed. Significance and novelty These results are important because polyembryonic maize kernel may be an alternative for adequate nutrient and essential oils intake. In addition, to the better agronomic characteristics offered by polyembryonic maize genotypes, which may imply a greater income for maize producers.

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Effect of high potassium diet on endothelial function

Cited by 24 publications

References 29 publications

Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial

Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial

A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

Mineral and fatty acid contents of maize kernels with different levels of polyembryony

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