Effect of High-Pressure Torsion on Microstructure, Mechanical and Operational Properties of Zn-1%Mg-0.1%Ca Alloy

Martynenko, Natalia; Anisimova, Natalia; Rybalchenko, O. V.; Kiselevskiy, Mikhail; Rybalchenko, Georgy; Tabachkova, N. Yu.; Железный, М. В.; Prosvirnin, D. V.; Filonenko, D. V.; Баженов, В. Е.; Колтыгин, А. В.; Белов, В. Д.; Добаткин, С. В.

doi:10.3390/met12101681

Cited by 7 publications

(11 citation statements)

References 36 publications

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“…Figure 2 shows the results of a study of the microstructure of alloys in the annealed state and after RS at 300 • C and 200 • C. The structure of the alloys after annealing consists of α-Zn grains surrounded by a thick phase layer. As shown earlier, this phase is a mixture of Mg 2 Zn 11 and MgZn 2 phases [39]. In addition, the inclusions with a regular geometric shape are observed in the structure of the Zn-1%Mg-0.1%Ca alloy.…”

Section: Resultssupporting

confidence: 63%

“…In addition, the inclusions with a regular geometric shape are observed in the structure of the Zn-1%Mg-0.1%Ca alloy. They were previously identified as CaZn 11 and CaZn 13 phases [39]. The average grain size of α-Zn was 36 ± 2 and 30 ± 3 µm for Zn-1%Mg and Zn-1%Mg-0.1%Ca alloys, respectively (Figure 2a,b).…”

Section: Resultsmentioning

confidence: 84%

“…Figure 3 and Table 1 show the results of X-ray diffraction analysis of alloys after RS at 300 • C and 200 • C. In our previous study, it was shown that three phases are formed in the annealed Zn-1%Mg alloy: α-Zn, Mg 2 Zn 11 , and MgZn 2 [40]. In the case of the Zn-1%Mg-0.1%Ca alloy, additional phases of CaZn 11 and CaZn 13 were found [39]. The phase composition of the alloys does not change after RS at both temperatures (Figure 3).…”

Section: Resultsmentioning

confidence: 90%

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Effect of Rotary Swaging on Mechanical and Operational Properties of Zn–1%Mg and Zn–1%Mg–0.1%Ca Alloys

Martynenko,

Anisimova,

Rybalchenko

et al. 2023

Metals

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A study of microstructure, phase composition, mechanical properties, corrosion processes, and biocompatibility in vitro of the Zn–1%Mg and Zn–1%Mg–0.1%Ca alloys in an annealed state and after rotary swaging (RS) is presented. Partially recrystallized microstructure is formed in the studied alloys after RS at 200 °C. RS reduces the mass fraction of intermetallic phases in comparison with annealed states of the alloys. RS at 200 °C increases the strength of the Zn–1%Mg and Zn–1%Mg–0.1%Ca alloys up to 248 ± 9 and 249 ± 9 with the growth of ductility up to 10.3 ± 3% and 14.2 ± 0.9%, respectively. The structure after RS at 200 °C does not lead to a change in the corrosion resistance of the studied alloys. However, an increase in the incubation period of the alloys in a growth medium slows down the degradation process due to the formation of a film consisting of degradation products. Rotary swaging does not impair the biocompatibility of the Zn–1%Mg and Zn–1%Mg alloys, maintaining the viability and integrity of blood cells, preventing hemolysis, and ensuring the adhesion and proliferation of osteogenic cells on the surface of samples.

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Section: Resultssupporting

confidence: 63%

Section: Resultsmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 90%

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Effect of Rotary Swaging on Mechanical and Operational Properties of Zn–1%Mg and Zn–1%Mg–0.1%Ca Alloys

Martynenko,

Anisimova,

Rybalchenko

et al. 2023

Metals

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“…The X-ray diffraction (XRD) analysis was performed on a Bruker D8 Advance diffractometer (CuKα radiation, λ = 1.54 Å; Bruker, Karlsruhe, Germany). More details can be found in [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Bioactivity Features of a Zn-1%Mg-0.1%Dy Alloy Strengthened by Equal-Channel Angular Pressing

Martynenko,

Anisimova,

Shinkareva

et al. 2023

Biomimetics

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The structure, phase composition, corrosion and mechanical properties, as well as aspects of biocompatibility in vitro and in vivo, of a Zn-1%Mg-0.1%Dy alloy after equal-channel angular pressing (ECAP) were studied. The structure refinement after ECAP leads to the formation of elongated α-Zn grains with a width of ~10 µm and of Mg- and Dy-containing phases. In addition, X-ray diffraction analysis demonstrated that ECAP resulted in the formation of the basal texture in the alloy. These changes in the microstructure and texture lead to an increase in ultimate tensile strength up to 262 ± 7 MPa and ductility up to 5.7 ± 0.2%. ECAP slows down the degradation process, apparently due to the formation of a more homogeneous microstructure. It was found that the alloy degradation rate in vivo after subcutaneous implantation in mice is significantly lower than in vitro ones. ECAP does not impair biocompatibility in vitro and in vivo of the Zn-1%Mg-0.1%Dy alloy. No signs of suppuration, allergic reactions, the formation of visible seals or skin ulcerations were observed after implantation of the alloy. This may indicate the absence of an acute reaction of the animal body to the Zn-1%Mg-0.1%Dy alloy in both states.

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“…Тем не менее, согласно работам других исследователей, можно сделать вывод о том, что применение иных методов обработки сплавов может ухудшить их биосовместимость. Например, есть данные о том, что после кручения под высоким давлением сплав Zn -1 %Mg -0,1 %Са демонстрировал умеренную цитотоксичность, тогда как цитотоксичность сплава Zn -1 %Mg значимо не отличалась от контроля [40,41]. Отдельно стоит отметить влияние изменения химического состава на биоактивные свойства сплава.…”

Section: Fig 5 Micrographs Of Tumor Cells Of the Skov-3 Line On The S...unclassified

Study of biocompatibility and antitumor cytotoxic activity <i>in vitro</i> of Zn – 1 %Mg and Zn – 1 %Mg – 0.1 %Ca alloys strengthened by equal angular pressing

Martynenko,

Anisimova,

Rybalchenko

et al. 2023

Rossijskij bioterapevtičeskij žurnal

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Introduction. The biological activity of potential biodegradable zinc-based alloys that are promising for oncoorthopedics was studied in this work. The alloys were processed by equal-channel angular pressing, which made it possible to increase their strength due to microstructure refinement and the ability to provide the functionality of osteosynthesis, fixed due to the metal structure developed on their basis.Aim. Investigation of effect of equal-channel angular pressing (ECAP) treatment on strength, ductility, degradation rate, biocompatibility in vitro and cytotoxicity against SKOV-3 tumor cells of the Zn – 1 %Mg and Zn – 1 %Mg – 0.1 %Ca alloys.Materials and methods. The Zn – 1 %Mg and Zn – 1 %Mg – 0.1 %Ca alloys in the initial state and after ECAP were used as objects of study, and blood cells of CBA mice were used as model systems. To assess the hemolytic activity, the samples were incubated with red blood cells for 4 and 24 hours at 37 °C, assessing the relative increase in the level of extracellular hemoglobin compared to the intact control. The cytotoxicity of the alloys was assessed by the change in the level of extracellular lactate dehydrogenase (LDH) activity after 24 hours of incubation with mononuclear white blood cells. The study of antitumor cytotoxic activity was carried out on human ovarian cancer cells of the SKOV-3 line in vitro, assessing their survival after 48 hours of incubation with alloy samples using the LDH test.Results. As a result of the studies, it was concluded that the studied alloys after ECAP treatment retained their biocompatibility, since there were no signs of hemolysis and cytotoxicity with respect to blood cells. However, contact with samples of all studied alloys in vitro induced a significant inhibition of the metabolic activity of the ovarian cancer cell culture in comparison with the control. Incubation with alloys samples leads to a decrease in cellular activity by an average of 49 % and 59 % for Zn – 1 %Mg and Zn – 1 %Mg – 0.1 %Ca alloys, respectively. The addition of calcium to the composition of the alloy Zn – 1 %Mg contributed to the growth of antitumor cytotoxic activity.Conclusion. Thus, based on the results of assessing the hemolytic activity and cytotoxicity of the samples, we can conclude that the studied alloys are biocompatible. It was also found that Zn – 1 %Mg and Zn – 1 %Mg – 0.1 %Ca alloys had a pronounced cytotoxic effect on SKOV-3 tumor cells. The obtained data indicate the prospects for the development of a new type of medical devices based on the studied alloys, promising, in particular, for oncoorthopedics: a metal structure developed on their basis can ensure the strength of osteosynthesis, reduce the risk of local recurrence of oncological disease and does not require a second operation to remove the device.

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Effect of High-Pressure Torsion on Microstructure, Mechanical and Operational Properties of Zn-1%Mg-0.1%Ca Alloy

Cited by 7 publications

References 36 publications

Effect of Rotary Swaging on Mechanical and Operational Properties of Zn–1%Mg and Zn–1%Mg–0.1%Ca Alloys

Effect of Rotary Swaging on Mechanical and Operational Properties of Zn–1%Mg and Zn–1%Mg–0.1%Ca Alloys

Bioactivity Features of a Zn-1%Mg-0.1%Dy Alloy Strengthened by Equal-Channel Angular Pressing

Study of biocompatibility and antitumor cytotoxic activity <i>in vitro</i> of Zn – 1 %Mg and Zn – 1 %Mg – 0.1 %Ca alloys strengthened by equal angular pressing

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